Evaluation of solid phase extraction for downstream separation of propane-1,3-diol and butan-1-ol from fermentation broth

Barski, Piotr; Kowalczyk, Janusz; Lindstaedt, Agnieszka; Puzewicz-Barska, Joanna; Witt, Dariusz

doi:10.1016/j.procbio.2012.03.013

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…The low concen-tration combined with the high boiling point and high hydrophilicity make the recovery of PDO from water a great challenge resulting in high process costs due to the large amount of energy required to remove the water through traditional methods, such as, for example, by distillation. Many separation methods have already been proposed in an attempt to make the process more economically attractive, such as chromatography, [8][9][10][11][12] electrodialysis, 13,14 reactive extraction, [15][16][17][18][19][20] solvent extraction (liquid-liquid extraction), 21,22 salting-out (repulsive extraction), 23 salting-out extraction (SOE), [24][25][26][27][28] membrane filtration, 29,30 and distillation. 31 However, in addition to the energy expenditure, each of these processes have serious disadvantages that make unappealing for large scale implementation.…”

Section: Introductionmentioning

confidence: 99%

A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

et al. 2023

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Section: Introductionmentioning

confidence: 99%

A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

et al. 2023

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“…For BuOH removal several groups have tried to use liquid–liquid extraction, e.g. with alkanes, esters, alcohols , or salting‐out techniques , as well as adsorption processes . Furthermore, pervaporation processes with novel membranes are promising for butanol recovery .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous production of 1,3‐propanediol and n‐butanol by Clostridium pasteurianum: In situ gas stripping and cellular metabolism

Groeger

Sabra

Zeng

2016

Engineering in Life Sciences

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Clostridium pasteurianum is a promising producer of the bulk chemicals 1,3‐propanediol and n‐butanol (BuOH), with significantly different product patterns and physiology from other typical Clostridia. Nevertheless, its growth and product formation are ultimately limited by the accumulation of inhibiting products, especially by BuOH. In this study, we implemented in situ gas stripping for BuOH removal and compared the stripping performance of external nitrogen (N2) and fermentation effluent gas (FG) from the process itself. Gas stripping was studied in fermentations of glycerol and a mixture of glycerol and glucose. In general, N2 exhibits favourable physical properties to strip out BuOH from an aqueous phase. However, in situ removal of butanol in C. pasteurianum culture with N2 stripping strongly perturbs the culture conditions such as the redox potential and thus the physiology of the microorganism, leading to enhanced formation of organic acids, especially in cosubstrate fermentation, whereas the use of FG does not show such perturbations. In an effort to explore the use of FG for gas stripping the effects of FG circulation rate and stirring speed of the bioreactor on BuOH stripping efficiency and the fermentation performance were studied in more detail. Mass transfer coefficient (kSa) of BuOH in the bioreactor was also characterized at different gas circulation rates and stirring speeds. In a fermentation of glycerol with FG stripping at a relatively high gas flow rate (7 vvm) as high as 39.2 g/L BuOH (total) and 53.7 g/L 1,3‐PDO can be simultaneously produced. The results are discussed in view of further process optimization and scale up.

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“…Pervaporation [4], extraction [5,10,14], reactive extraction [6][7][8][9]11,13,15,19,27], vacuum distillation [16], aqueous two phase extraction [12,17,18,20,[22][23][24][25][26] and adsorption [21] have been proposed as separation methods. Compared with other separation techniques, extraction is considered to possess several advantages, such as large throughput and low energy consumption.…”

Section: Introductionmentioning

confidence: 99%

Reactive Extraction of 1,3-Propanediol with Aldehydes in the Presence of a Hydrophobic Acidic Ionic Liquid as a Catalyst

Matsumoto

Nonomura

Kondo

2015

SERDJ

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The biological production of 1,3-propanediol from glycerol, which is a by-product in a bio-diesel production process, is of great interest. However, major difficulties still exist in downstream processing because 1,3-propanediol has a high boiling point. In this study, reactive extraction with aldehydes in the presence of a hydrophobic acidic ionic liquid as an acidic catalyst was used to extract 1,3-propanediol from an aqueous solution. Hydrophobic acidic ionic liquids have successfully played the role of acidic catalysts for acetalization as well as hydrochloric acid. Aromatic compounds as diluents were preferable for this acetalization. Conversion of 60 g/dm 3 of 1,3 propanediol reached 96% at a concentration of 4.0 mol/dm 3 of 1-butanal in toluene.

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Evaluation of solid phase extraction for downstream separation of propane-1,3-diol and butan-1-ol from fermentation broth

Cited by 12 publications

References 12 publications

A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

Simultaneous production of 1,3‐propanediol and n‐butanol by Clostridium pasteurianum: In situ gas stripping and cellular metabolism

Reactive Extraction of 1,3-Propanediol with Aldehydes in the Presence of a Hydrophobic Acidic Ionic Liquid as a Catalyst

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Evaluation of solid phase extraction for downstream separation of propane-1,3-diol and butan-1-ol from fermentation broth

Cited by 12 publications

References 12 publications

A CO2-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

A CO2-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

Simultaneous production of 1,3‐propanediol and n‐butanol by Clostridium pasteurianum: In situ gas stripping and cellular metabolism

Reactive Extraction of 1,3-Propanediol with Aldehydes in the Presence of a Hydrophobic Acidic Ionic Liquid as a Catalyst

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A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water

A CO₂-responsive method for separating hydrophilic organic molecules from aqueous solutions: solvent-assisted switchable water