Evaluation of Sodium (<sup>23</sup>Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer’s Disease

Mohamed, Sherif A.; Herrmann, Katrin; Adlung, Anne; Paschke, Nadia; Hausner, Lucrezia; Frölich, Lutz; Schad, Lothar R.; Groden, Christoph; Kerl, H

doi:10.21873/invivo.12275

Cited by 22 publications

(25 citation statements)

References 33 publications

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“…Education, years 14.9 ± 4.7 [6,22] 14.0 ± 3.3 [3,18] MMSE (/30) 19.6 ± 6.6 [2,29] 29.3 ± 0.8 [28,30] MoCA (/30) 1 16.1 ± 7.8 [0,29] 28.1 ± 1.6 [25,30] Total Free Recall (/48) 5.9 ± 6.9…”

Section: Ad Patients Control Subjectsmentioning

confidence: 99%

“…In particular, there are findings that the ATP-synthase, an essential pump for ATP production as an energy source, might be affected in AD. 23 Only two preliminary 23 Na-MRI studies have been carried out so far in AD, one on a small cohort of five mild AD patients, 24 and one recent study at 3 Tesla 25 pointing to increased intensities from 23 Na-MRI in brain regions typically affected by AD, such as the hippocampus. However, there have not been any previous 23 Na-MRI studies so far in AD under technically advanced conditions with the improved signal-tonoise ratio (SNR), improved resolution of 7 Tesla magnetic fields, and with a quantification of TSC complemented by high-resolution 1 H-MRI, tau and amyloid PET neuroimaging as well as clinical assessment.…”

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confidence: 99%

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What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

Haeger

Bottlaender

Lagarde

et al. 2021

Alzheimer's & Dementia

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The pathophysiological processes underlying the development and progression of Alzheimer's disease (AD) on the neuronal level are still unclear. Previous research has hinted at metabolic energy deficits and altered sodium homeostasis with impaired neuronal function as a potential metabolic marker relevant for neurotransmission in AD. Using sodium ( 23 Na) magnetic resonance (MR) imaging on an ultra-high-field 7Tesla MR scanner, we found increased cerebral tissue sodium concentration (TSC) in 17 biomarker-defined AD patients compared to 22 age-matched control subjects in vivo. TSC was highly discriminative between controls and early AD stages and was predictive for cognitive state, and associated with regional tau load assessed with flortaucipir-positron emission tomography as a possible mediator of TSC-associated neurodegeneration. TSC could therefore serve as a non-invasive, stage-dependent, metabolic imaging marker. Setting a focus on cellular metabolism and potentially disturbed interneuronal communication due to energy-dependent altered cell homeostasis could hamper progressive cognitive decline by targeting these processes in future interventions.

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Section: Ad Patients Control Subjectsmentioning

confidence: 99%

mentioning

confidence: 99%

What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

Haeger

Bottlaender

Lagarde

et al. 2021

Alzheimer's & Dementia

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“…volume in the amygdala, hippocampus, and WM as compared to healthy controls, which denotes neuronal loss. 77 Hence,…”

Section: ■ Sodium Mri Applicationsmentioning

confidence: 97%

“…82 AD begins with slight impairments in short-term memory and cognitive functions, which further extend and progress to dementia. 77 This causes interference in the daily living activities and extensive behavioral changes ultimately leading to motor difficulties. As neural cell death has been well established in AD, 23 Na MRI has been utilized to determine any alteration in the sodium levels of the brain.…”

Section: ■ Sodium Mri Applicationsmentioning

confidence: 99%

“…Patients with AD have also shown a significant increase in the tissue sodium Figure 6. Brain disorders exhibiting abnormal sodium concentration levels during 23 Na imaging with the disease progression including AD, 77,82 brain tumor, 42,83 epilepsy, 84 MS, 85 cerebral ischemia 86 Friedreich's ataxia, 87 Huntington's disease, 88 glioblastoma, 89 Parkinson's disease, 90 stroke, 91 migraine, 92 and cerebral hemorrhage. volume in the amygdala, hippocampus, and WM as compared to healthy controls, which denotes neuronal loss.…”

Section: ■ Sodium Mri Applicationsmentioning

confidence: 99%

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Comprehensive Account of Sodium Imaging and Spectroscopy for Brain Research

Handa

Samkaria

Sharma

et al. 2022

ACS Chem. Neurosci.

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Sodium ( 23 Na) is a vital component of neuronal cells and plays a key role in various signal transmission processes. Hence, information on sodium distribution in the brain using magnetic resonance imaging (MRI) provides useful information on neuronal health. 23 Na MRI and MR spectroscopy (MRS) improve the diagnosis, prognosis, and clinical monitoring of neurological diseases but confront some inherent limitations that lead to low signal-to-noise ratio, longer scan time, and diminished partial volume effects. Recent advancements in multinuclear MR technology have helped in further exploration in this domain. We aim to provide a comprehensive description of 23 Na MRI and MRS for brain research including the following aspects: (a) theoretical background for understanding 23 Na MRI and MRS fundamentals; (b) technological advancements of 23 Na MRI with respect to pulse sequences, RF coils, and sodium compartmentalization; (c) applications of 23 Na MRI in the early diagnosis and prognosis of various neurological disorders; (d) structural−chronological evolution of sodium spectroscopy in terms of its numerous applications in human studies; (e) the dataprocessing tools utilized in the quantitation of sodium in the respective anatomical regions.

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Multidimensional compressed sensing to advance ²³Na multi‐quantum coherences MRI

Licht,

Reichert,

Guye

et al. 2023

Magnetic Resonance in Med

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PurposeSodium (23Na) multi‐quantum coherences (MQC) MRI was accelerated using three‐dimensional (3D) and a dedicated five‐dimensional (5D) compressed sensing (CS) framework for simultaneous Cartesian single (SQ) and triple quantum (TQ) sodium imaging of in vivo human brain at 3.0 and 7.0 T.Theory and Methods3D 23Na MQC MRI requires multi‐echo paired with phase‐cycling and exhibits thus a multidimensional space. A joint reconstruction framework to exploit the sparsity in all imaging dimensions by extending the conventional 3D CS framework to 5D was developed. 3D MQC images of simulated brain, phantom and healthy brain volunteers obtained from 3.0 T and 7.0 T were retrospectively and prospectively undersampled. Performance of the CS models were analyzed by means of structural similarity index (SSIM), root mean squared error (RMSE), signal‐to‐noise ratio (SNR) and signal quantification of tissue sodium concentration and TQ/SQ ratio.ResultsIt was shown that an acceleration of three‐fold, leading to less than min of scan time with a resolution of at 3.0 T, are possible. 5D CS improved SSIM by 3%, 5%, 1% and reduced RMSE by 50%, 30%, 8% for in vivo SQ, TQ, and TQ/SQ ratio maps, respectively. Furthermore, for the first time prospective undersampling enabled unprecedented high resolution from to MQC images of in vivo human brain at 7.0 T without extending acquisition time.Conclusion5D CS proved to allow up to three‐fold acceleration retrospectively on 3.0 T data. 2‐fold acceleration was demonstrated prospectively at 7.0 T to reach higher spatial resolution of 23Na MQC MRI.

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Evaluation of Sodium (²³Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer’s Disease

Cited by 22 publications

References 33 publications

What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

Comprehensive Account of Sodium Imaging and Spectroscopy for Brain Research

Multidimensional compressed sensing to advance ²³Na multi‐quantum coherences MRI

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Evaluation of Sodium (23Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer’s Disease

Cited by 22 publications

References 33 publications

What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

What can 7T sodium MRI tell us about cellular energy depletion and neurotransmission in Alzheimer's disease?

Comprehensive Account of Sodium Imaging and Spectroscopy for Brain Research

Multidimensional compressed sensing to advance 23Na multi‐quantum coherences MRI

Contact Info

Product

Resources

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Evaluation of Sodium (²³Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer’s Disease

Multidimensional compressed sensing to advance ²³Na multi‐quantum coherences MRI