Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester

Bhandari, Krishna Hari; Lee, Dong Xun; Newa, Madhuri; Yoon, Sung Ii; Kim, Jung Sun; Kim, Dae Duk; Kim, Jung-Ae; Yoo, Bong Kyu; Woo, Jong Soo; Lyoo, Won Seok; Lee, Jae Hwi; Choi, Han Gon; Yong, Chul Soon

doi:10.1007/s12272-001-1148-8

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…Underneath the dermis, the subcutaneous tissue or hypodermis comprises adipose cells, fibroblasts, macrophages, and fibrous connective tissues and provides cushioning and support to the dermis and epidermis. [ 143,146 ]…”

Section: Topical Drug Delivery With Nanomaterialsmentioning

confidence: 99%

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Mustfa

Maurizi

McGrath

et al. 2020

Advanced Therapeutics

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Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co‐delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.

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Section: Topical Drug Delivery With Nanomaterialsmentioning

confidence: 99%

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Mustfa

Maurizi

McGrath

et al. 2020

Advanced Therapeutics

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show abstract

“…The sample is deposited in the donor compartment on the epidermis. The diffusion rate of the active substance to the receptor compartment is determined by an appropriate and validated analytical method, such as chromatographic or spectroscopic techniques, liquid scintillation counting or other suitable methods [27,28].…”

Section: In Vitro Diffusion Modelsmentioning

confidence: 99%

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

Contri

Fiel

Pohlmann

et al. 2011

Nanocosmetics and Nanomedicines

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Abstract. Nanotechnology can be used to modify the drug permeation/penetration of encapsulated substances, through the manipulation of many different factors, including direct contact with the skin surface and controlled release. In general, nanoparticles cannot cross the skin barrier, which can be explained by the cell cohesion and lipids of the stratum corneum, the outermost skin layer. The device most commonly used to study the transport of substances and nanoparticles across the skin is the Franz vertical diffusion cell, followed by the substance quantification in the receptor fluid or determination of the amount retained in the skin. Microscopy techniques have also been applied in skin penetration or permeation experiments. This chapter will present the fundamental considerations regarding the transport of encapsulated substances and/or nanoparticles across the skin, the experimental models applied in these studies and a review of the main studies reported in the literature in order to allow the reader to gain insight into the current knowledge available in this area.

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“…(ii) Below the epidermis is the dermis, usually a 0.3–5 mm thick layer that contains connective tissue, sweat glands, hair follicles, and a network of capillaries, lymphatic vessels and nerve endings. (iii) The deepest layer of the skin is the subcutaneous tissue or hypodermis, which is composed of loose, white, fibrous connective tissue in which fat provides cushioning [3]. …”

Section: Introductionmentioning

confidence: 99%

“…Chemical enhancers , such as fatty acids, surfactants, esters, alcohols, polyalcohols, pyrrolidones, amines, amides, sulfoxides, terpenes, alkanes and phospholipids [3,6], can be used to enhance topical drug penetration by: (i) perturbing the highly ordered structure of the SC; (ii) solubilizing and extracting the keratin and/or lipid components of the SC; (iii) fluidizing the crystalline structure and dissolving the lipids of the SC; or (iv) improving the partitioning of a drug, co-enhancer or solvent into the SC [3,6,7]. Unfortunately, chemical penetration enhancers tend to be skin irritants, due to their disruptive effect on the lipid structures of the skin.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

444

227

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This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

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Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester

Cited by 13 publications

References 29 publications

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

Nanoparticles and nanofibers for topical drug delivery

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