Evaluation of Skeletal Muscle Relaxant Activity of Apigenin in Animal Experimental Models

Basheerudd, Syed Mohammed; Abdulaziz, Basheerahmed; Alanazi, Ahmad; Almusharra, Bader; Alanazi, Naif; Saad, K.H.M.; Alanazi, Sami; Abduallah, Khalid; Alrashid, Saad; Alanazi, Faisal; Alamri, Abdulhakeem S.; Alsanie, Walaa F.; Alhomrani, Majid

doi:10.3923/ijp.2021.400.407

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Recent research validated apigenin's ability to relax muscles in animal models [16]. According to research published by Nakazawa et al [17], the dopaminergic system is involved in the possible antidepressant effect of apigenin. At the same time, another study demonstrated the role of α-adrenergic, dopaminergic, and 5-HT3 serotonergic receptors in mediating the antidepressant action of apigenin [18].…”

Section: Introductionmentioning

confidence: 96%

“…The inhibition of MAO increases levels of monoamines such as serotonin in the brain, which is linked to the disappearance of depressive symptoms [20]. The functioning of gamma-aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) receptors has been shown in several cases to be inhibited by apigenin, and antagonizing these receptors may relieve depression [17,21].…”

Section: Introductionmentioning

confidence: 99%

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Potential Antioxidant Activity of Apigenin in the Obviating Stress-Mediated Depressive Symptoms of Experimental Mice

et al. 2022

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This study aimed to examine the antidepressant properties of apigenin in an experimental mouse model of chronic mild stress (CMS). Three weeks following CMS, albino mice of either sex were tested for their antidepressant effects using the tail suspension test (TST) and the sucrose preference test. The percentage preference for sucrose solution and the amount of time spent immobile in the TST were calculated. The brain malondialdehyde (MDA) levels, catalase activity, and reduced glutathione levels were checked to determine the antioxidant potential of treatments. When compared to the control, animals treated with apigenin during the CMS periods showed significantly shorter TST immobility times. Apigenin administration raised the percentage preference for sucrose solution in a dose-dependent manner, which put it on par with the widely used antidepressant imipramine. Animals treated with apigenin displayed a significantly (p ˂ 0.05) greater spontaneous locomotor count (281) when compared to the vehicle-treated group (245). Apigenin was also highly effective in significantly (p ˂ 0.01) lowering plasma corticosterone levels (17 vs. 28 µg/mL) and nitrite (19 vs. 33 µg/mL) produced by CMS in comparison to the control group. During CMS, a high dose (50 mg/kg) of apigenin was given, which greatly increased the reduced glutathione level while significantly decreasing the brain’s MDA and catalase activity when compared to the control group. As a result, we infer that high doses of apigenin may have potential antidepressant effects in animal models via various mechanisms.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Potential Antioxidant Activity of Apigenin in the Obviating Stress-Mediated Depressive Symptoms of Experimental Mice

et al. 2022

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“…Umbelliferon produces a rapid and transient relaxation dependent upon the release of nitric oxide from the endothelium (Roberts, Allen et al 2013). Asdaq, S.M.B reported that its combination effect with skeletal muscle relaxant properties along with sedative and anti-depressive effects at doses of 50mg per kg caused a decrease in muscle strength and muscle tone (Asdaq, Mannasaheb et al 2021). It also produces enhanced smooth…”

Section: Introductionmentioning

confidence: 99%

An Overview of Anti-Inflammatory, Antioxidant, Anti-Cancer, Anti-Hyperlipidemic, Neuroprotective and Muscle Relaxant Effects of Natural Flavonoid, Apigenin; A Review

AZEEM,

KHARL,

NIAZI

et al. 2024

Biol Clin Sci Res J

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Apigenin (4′, 5, 7,-trihydroxyflavone), a natural glycoside belonging to a class of cyclone, is found in many different forms in plants and vegetables such as grapefruits, parsley, onions, oranges, tea, chamomile, wheat, sprouts, oregano, artichokes and in some seasonings. It effectively treats various anti-inflammatory disorders because it is less toxic, non-mutagenic, and potent against skeletal muscle sarcoplasmic reticulum. Furthermore in combination with allopathic drugs, its activity was enhanced as an anti-inflammatory, antioxidant, cardioprotective, neuroprotective, and anticancer agent. Little data was found that emphasized its role as an anti- hypoglycemic and sedative agent; however, it was found to promote hair growth by inhibiting the TGF-B1 pathway. Different characterization techniques were used to determine physicochemical properties, and various formulations of apigenin with other polymers have been done to enhance its biological role. The literature search used various scholarly search engines (Google Scholar, PubMed, Springer Link, etc.). A total of 355 research articles were reviewed, and it was observed that 34% of articles were about anti-inflammatory, 15% of articles were about neuroprotective, and 10% of studies were about anti-cancer use of apigenin. Thus, the current review focuses on its activity, characterization and limitations of apigenin role.

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The role of serotonergic and catecholaminergic systems for possible antidepressant activity of apigenin

Al-Yamani¹,

Asdaq²,

Alamri

et al. 2022

Saudi Journal of Biological Sciences

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Background and objective Although, the anti-depressant like effects of apigenin (APG) are documented in the literature, the underlying mechanism for exerting such an effect is still not clear. In this research, an attempt was made to determine the possible role of APG for antidepressant activity through serotonergic and catecholaminergic systems using standardized animal models. Materials and methods The antidepressant property of APG was determine by involving tail suspension (TST) and modified forced swimming tests (MFST). The effect of APG was evaluated at 25 and 50 mg/kg. In mechanistic models, animals were pretreated with catecholaminergic and serotonergic antagonists prior to administration of APG. The results obtained were statistically analyzed to determine the level of significance. Results The period of immobility in both models (TST and MFST) was significantly reduced by APG (25 and 50 mg/kg). The best therapetuic dose of APG (50 mg/kg) was selected for the mechanistic study. The anti-immobility effect of APG declined to a significant extent upon pretreatment with catecholaminergic antagonists (α-methyl-para-tyrosine methyl ester; SCH 23390; sulpiride; phentolamine) and serotonergic inhibitors ( p -clorophenylalanine-methyl-ester; ondansetron) in both TST and MFST models. The antidepressant benefits of apigenin were only modestly reversed when rats were given propranolol. Conclusions The findings suggest that APG's antidepressant effect is mediated by the α-adrenergic, dopaminergic and 5-HT3 serotonergic receptors.

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Evaluation of Skeletal Muscle Relaxant Activity of Apigenin in Animal Experimental Models

Cited by 3 publications

References 23 publications

Potential Antioxidant Activity of Apigenin in the Obviating Stress-Mediated Depressive Symptoms of Experimental Mice

Potential Antioxidant Activity of Apigenin in the Obviating Stress-Mediated Depressive Symptoms of Experimental Mice

An Overview of Anti-Inflammatory, Antioxidant, Anti-Cancer, Anti-Hyperlipidemic, Neuroprotective and Muscle Relaxant Effects of Natural Flavonoid, Apigenin; A Review

The role of serotonergic and catecholaminergic systems for possible antidepressant activity of apigenin

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