Evaluation of Skeletal Muscle Mass in Patients with Chronic Liver Disease Shows Different Results Based on Bioelectric Impedance Analysis and Computed Tomography

Kikuchi, Nahoko; Uojima, Haruki; Hidaka, Hiroyoshi; Iwasaki, Shigeo; Wada, Naohisa; Kubota, Kousuke; Nakazawa, Takahide; Shibuya, Akitaka; Kako, Makoto; Take, A; Sakaguchi, Yoshihiko; Sato, Teruko; Kusano, Chika

doi:10.1159/000526563

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Combining these techniques will provide a clinical estimation of the presence and degree of sarcopenia. If available, bioelectrical impedance analysis with phase angle measurement is also another tool to assess body composition and determine muscle mass [ 55 ]. The technique of bioimpedance analysis (BIA) involves measuring the electrical impedance of body tissues to evaluate body composition.…”

Section: Factors Contributing To Sarcopenia Frailty and Malnutrition ...mentioning

confidence: 99%

Clinical Overview of Sarcopenia, Frailty, and Malnutrition in Patients With Liver Cirrhosis

Kusnik,

Penmetsa,

Chaudhary

et al. 2024

Gastroenterol Res

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Sarcopenia, frailty, and malnutrition in patients with liver cirrhosis are commonly observed and are associated with higher long-term mortality. Therefore, recognizing patients with increased nutritional risk and providing recommended interventions are essential in the long- and short-term management of cirrhosis, especially as alcoholic and non-alcoholic fatty liver disease continues to rise. Various assessment tools are available to gauge frailty and malnutrition but are infrequently used. Given the global burden of liver cirrhosis, periodic screening for malnutrition, sarcopenia, and frailty is desperately needed as it improves liver transplantation outcomes. Necessary steps include addressing knowledge gaps in professional healthcare workers and patients and using standardized assessment tools to counteract physical deconditioning as early as possible. One potential method for assessing sarcopenia involves using computed tomography to evaluate the skeletal muscle index. Regarding frailty, useful tools for longitudinal assessment include the liver frailty index and the Karnofsky performance status. Addressing educational requirements related to malnutrition involves seeking guidance from dieticians, who can provide counseling on achieving sufficient calorie and protein intake to combat the progression of malnutrition.

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Section: Factors Contributing To Sarcopenia Frailty and Malnutrition ...mentioning

confidence: 99%

Clinical Overview of Sarcopenia, Frailty, and Malnutrition in Patients With Liver Cirrhosis

Kusnik,

Penmetsa,

Chaudhary

et al. 2024

Gastroenterol Res

View full text Add to dashboard Cite

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Comparison of bioelectrical impedance analysis and computed tomography for the assessment of muscle mass in patients with gastric cancer

Zuo,

Zhou,

Zhang

et al. 2024

Nutrition

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Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease

Fudeyasu,

Ushio,

Nomura

et al. 2024

Sci Rep

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This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB-4) index groups according to the degree of liver fibrosis. The prevalence of sarcopenia and incidence of decreased gait speed (< 1.0 m/s) were compared among the three groups. Logistic regression analysis was performed to investigate factors affecting the risk of decreased gait speed. No significant difference was observed in the prevalence of sarcopenia among the three groups, but the incidence of decreased gait speed significantly differed (p = 0.029). When analyzed individually, a significant difference in decreased gait speed incidence was observed between the high and low FIB-4 index groups (p = 0.014). In logistic regression analysis, the progression of liver fibrosis (odds ratio: 1.32, 95% confidence interval: 1.13–1.55) and lower extremity muscle strength (LEMS) (odds ratio: 0.92, 95% confidence interval: 0.88–0.97) were significantly associated with decreased gait speed. As liver fibrosis progresses in older patients with CLD, it becomes important to focus on not only skeletal muscle mass and grip strength, but also gait speed and LEMS.

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Evaluation of Skeletal Muscle Mass in Patients with Chronic Liver Disease Shows Different Results Based on Bioelectric Impedance Analysis and Computed Tomography

Cited by 3 publications

References 26 publications

Clinical Overview of Sarcopenia, Frailty, and Malnutrition in Patients With Liver Cirrhosis

Clinical Overview of Sarcopenia, Frailty, and Malnutrition in Patients With Liver Cirrhosis

Comparison of bioelectrical impedance analysis and computed tomography for the assessment of muscle mass in patients with gastric cancer

Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease

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