Evaluation of Side Effects of Isotretinoin in 150 Patients with Acne Vulgaris

Karadağ, Ayşe Serap; Çalka, Ömer; Akdeniz, Necmettın

doi:10.4274/turkderm.45.09

Cited by 15 publications

(13 citation statements)

References 13 publications

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“…Our findings confirm that adverse cutaneous and mucous membrane reactions may be seen during isotretinoin therapy, and these were observed in the great majority of patients. Such reactions and poor tolerance of them have been reported by a number of previous studies (3,5,7,17,18). We therefore recommend that patients be given suitable skin care instructions during isotretinoin therapy.…”

Section: Discussionmentioning

confidence: 65%

The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

Çölgeçen¹,

Özyurt²,

Kesikoğlu³

2016

Turk J Med Sci

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Section: Discussionmentioning

confidence: 65%

The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

Çölgeçen¹,

Özyurt²,

Kesikoğlu³

2016

Turk J Med Sci

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“…Previous researches have highlighted the harmful adverse effects of isotretinoin treatment [20] . Many undesired effects including sparse hair and hair thinning, conjunctivitis, mucous dryness and sensitivity to ultraviolet radiation [21] . Isotretinoin reduces sebaceous gland surface area and suppresses sebum production by in inhibiting sebaceous lipid synthesis [22] .…”

Section: Discussionmentioning

confidence: 99%

Histological effect of high versus low dose isotretinoin and possible protective role of Tiron on skin of adult male albino rat

Soliman

El-Haroun

Kafafy

et al. 2019

Egyptian Journal of Histology

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Background: Isotretinoin is one of the most effective drugs in acne treatment. It is retinoic acid derivative. Systemic administration of isotretinoin may induce many adverse effects. Tiron has antioxidant properties and could ameliorate skin damage and cell apoptosis. Aim of the work: To evaluate the adverse effect of high versus low dose isotretinoin on the skin of adult albino rats and the probable protective effect of tiron. Material and Method: Sixty adult male albino rats were divided into five groups: control group I (DMSO and saline), tiron treated group II (300 mg/kg orally), isotretinoin treated group III (6 mg/kg /day IP), isotretinoin treated group IV (3 mg/kg / day IP), and protective group V which treated with isotretinoin and tiron. Rats of the last group were subdivided into 2 equal subgroups (V a & V b) which received isotretinoin at a dose of 6mg and 3mg /kg/day respectively with tiron. At the end of the studied period, rats were then sacrificed and the samples were taken for histological, histochemical, immunohistochemical and morphometric studies. Results: Animals treated with isotretinoin at a dose of 6mg/kg/day showed thinning of all layers of epidermis. Epidermal cells were degenerated, exfoliated with marked reduction in cellular proliferation and associated with ill-defined basement membrane. Sebaceous glands showed a marked reduction in surface area and some cells appeared degenerated and dermis revealed loss of its normal architecture and increased densely packed collagen fibers seen by Mallory trichrome stain. These degenerative changes were less apparent in administration of isotretinoin at a lower dose of 3mg/kg/day. Concomitant administration of tiron and isotretinoin induced an observable improvement protection against these changes compared to control, especially in low dose. Conclusion: The pronounced skin damage induced by isotretinoin can be ameliorated by joined therapy of tiron and isotretinoin.

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“…53 Iso is also known to be a potent teratogen and one of the presumed mechanisms of Iso teratogenesis is production of toxic ROS. [24][25][26]55 It has been shown that incubation of neural crest cell culture with Iso evokes an increased release of ROS. 25 Similarly, in another study it has been suggested that because Iso is metabolized by prostaglandin synthase to a toxic peroxyl radical, a prostaglandin synthetase inhibitor, acetylsalicylic acid may emerge as an anti-teratogenic agent.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Isotretinoin on Oxidative Stress in Severe Acne Vulgaris Patients

Yorulmaz¹,

Metin²,

Işıkoğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Oxidative stress (OS) has been implicated in the pathogenesis of a variety of diseases including acne vulgaris. Isotretinoin (Iso), which is accepted to be the most effective medication in the treatment of nodulocystic acne, has a number of adverse effects related to OS. The aim of this study was to enlighten the disputed role of OS in the pathogenesis of acne and the effects of Iso on OS. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fifty patients with nodulocystic acne who were receiving Iso and fifty healthy controls were included in the study. Blood samples were obtained from patients before and on the 45 th day of treatment and once from the controls. Serum total oxidant status (TOS), total antioxidant capacity (TAC) levels were measured spectrophotometrically and oxidative stress index (OSI) was calculated as a ratio of TOS to TAC. R Re es su ul lt ts s: : Before Iso, serum TOS levels and OSI values were significantly lower in the patients compared to the controls (p=0.004 and p=0.006, respectively). On the other hand, there was no statistically significant difference between the groups for TAC levels (p=0.285). When the values of patients before and after the treatment were compared, it was revealed that serum TOS levels and OSI values had significantly increased (p=0.035 and p=0.043, respectively), yet, TAC levels were not statistically different (p=0.308). C Co on nc cl lu us si io on n: : These results suggest that OS is decreased in patients with acne. Besides, Iso's exact mechanism of action on OS remains somewhat obscure. Further studies are required to clarify the relationship between acne, Iso and OS.K Ke ey y W Wo or rd ds s: : Acne vulgaris; isotretinoin; oxidative stress Ö ÖZ ZE ET T A Am ma aç ç: : Oksidatif stres (OS) akne vulgaris de dahil olmak üzere birçok hastalığın patogenezinde suçlanmıştır. Nodülokistik akne tedavisinde en etkili ilaç olarak kabul edilen izotretinoin (İzo), OS ile ilişki çok sayıda yan etkiye sahiptir. Bu çalışmanın amacı akne patogenezinde OS'nin rolünü ve İzo'nun OS üzerindeki etkilerini ortaya koymaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmaya İzo tedavisi alan 50 nodülokistik akne hastası ve 50 sağlıklı kontrol dahil edildi. Kan örnekleri hastalardan tedavinin öncesinde ve 45. gününde; kontrollerden ise bir kez alındı. Serum total oksidan seviye (TOS) ve total antioksidan kapasite (TAK) spektrofotometrik yöntemle ölçüldü; TOS'un TAK'a oranı kullanılarak da oksidatif stres indeksi (OSİ) hesaplandı. B Bu ul lg gu ul la ar r: : Kontrol grubu ile karşılaştırıldığında, İzo öncesinde hastaların serum TOS seviyeleri ve OSİ değerleri anlamlı derecede düşük tespit edildi (sırasıyla p=0,004 ve p=0,006). Bunun aksine, TAK düzeyleri göz önünde bulundurulduğunda iki grup arasında istatistiksel olarak anlamlı bir fark yoktu (p=0,285). Tedavi öncesine göre sonrasında ise, serum TOS düzeylerinin ve OSİ değerlerinin anlamlı derecede arttığı (sırasıyla p=0,035 ve p=0,043), ancak TAK sev...

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Evaluation of Side Effects of Isotretinoin in 150 Patients with Acne Vulgaris

Cited by 15 publications

References 13 publications

The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

Histological effect of high versus low dose isotretinoin and possible protective role of Tiron on skin of adult male albino rat

The Effect of Isotretinoin on Oxidative Stress in Severe Acne Vulgaris Patients

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