Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Mahendran, Balu; Kumar, Sanjay

doi:10.9790/0853-0513336

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…10 Serum total sialic acid was significantly increased in the diabetic group compared to the control group (p<0.001). This is similar to the earlier studies by Balu Mahendran et al, 2013;Ekin et al, 2003;Melidonis et al, 1988;Crook et al, 1993. 11 -13 Elevated level of serum sialic acid is a risk factor for overall mortality in type 2 diabetes mellitus patients.…”

Section: Discussionsupporting

confidence: 93%

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Nair¹,

Osman²

2017

jemds

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BACKGROUNDSialic acid, an acetylated derivative of neuraminic acid, is reported to be a marker of acute phase response. Elevated serum total sialic acid concentration may reflect the existence or activity of an atherosclerotic process.The aims and objectives of the current study is to evaluate serum total sialic acid and various lipid parameters in patients with type 2 diabetes mellitus and to examine the relationship between serum total sialic acid with serum lipids which strongly influence the occurrence and advance of atherosclerosis. MATERIALS AND METHODSThe study group consisted of 40 type 2 diabetic patients and 40 healthy controls between the age group of 20 and 60 years. The serum total sialic acids were analysed by the thiobarbituric acid assay of Warren. Fasting plasma glucose and fasting lipid profile were measured by commercially procured kits in a fully autoanalyser. Statistical analysis was done using SPSS version 22.0. Quantitative data was expressed as mean and SD and quantitative data for the two groups were compared with unpaired 't' test. Association between total sialic acid and lipid parameters was assessed by Pearson correlation. p<0.05 is considered significant.

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Section: Discussionsupporting

confidence: 93%

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Nair¹,

Osman²

2017

jemds

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Evaluation of sialic acid levels in type-2 diabetes mellitus patients in NCR, Delhi

Singh¹,

Nandkeoliar²,

Punia³

et al. 2020

IJCBR

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Diabetes mellitus is one of the most common metabolic disorders characterized by chronic hyperglycemia, and it is associated with increased prevalence of microvascular complications. Serum sialic acid has developed as a potential risk factor for Type-2 Diabetes Mellitus. In type-2 diabetic individuals, elevated serum sialic acid is often observed as compared to non-diabetic individuals.The study conducted in NCR, Delhi was a cross-sectional analysis on 70 participants between the age group of 30 to 70 years. This included two groups of thirty-five individuals with type-2 diabetes mellitus recruited as cases (15 males and 20 females) and thirty-five individuals without diabetes taken as controls (16 males and 19 females). Fasting blood glucose and serum sialic acid in the both groups were measured.In the present study, serum sialic acid levels were shown to be increased in type-2 diabetes mellitus (76.60±7.89) compared to non-diabetics (39.66±9.55) with a statistically significant p-value of < 0.001. On the basis of present study, it is concluded that the serum sialic acid levels were found to be increased in type-2 diabetic patients of Delhi -NCR which reflect that these patients were at the risk of developing microvascular complications. Therefore, estimating sialic acid levels may aid in early diagnosis and prevention of microvascular complications caused by type-2 diabetes mellitus.

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Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Abstract: Sialic acid-rich glycoprotein is found mainly in cell membranes

Cited by 2 publications

References 24 publications

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Evaluation of sialic acid levels in type-2 diabetes mellitus patients in NCR, Delhi

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