Evaluation of Sexually Abused and Nonabused Young Girls for Intravaginal Human Papillomavirus Infection

Gutman, Laura T.; Claire, Karen St.; Herman-Giddens, Marcia E.; Johnston, William W.; Phelps, William C.

doi:10.1001/archpedi.1992.02160180052016

Cited by 33 publications

(29 citation statements)

References 33 publications

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“…13,[19][20][21][22] These findings are also consistent with the growing literature showing that sexual assaults and abuse are associated with an increased risk of an STI, 44 including infection with human immunodeficiency virus (HIV) 45 and HPV, 46 and with an increased risk of cervical dysplasia. 24 Furthermore, it is clear that IPV has physical health effects on women beyond STI and injuries.…”

Section: Discussionsupporting

confidence: 88%

Intimate Partner Violence and Cervical Neoplasia

Coker

Sanderson

Fadden

et al. 2000

Journal of Women's Health & Gender-Based Medicine

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Intimate partner violence (IPV) is associated with a range of adverse physical health outcomes, including chronic and infectious diseases. An emerging literature suggests that partner violence and specifically sexual violence may be associated with an increased risk of cervical neoplasia. To assess the risk of preinvasive and invasive cervical cancer in a cross-sectional study of women screened for IPV by type, frequency and duration, 1152 women ages 18-65 were recruited from family practice clinics in 1997-1998. They were screened for IPV during a brief in-clinic interview, and health history and current status were assessed in a follow-up interview. Of 1152 women surveyed, 14 (1.2%) reported cervical cancer, and 20.3% (n 5 234) reported treatment for cervical neoplasia. Ever experiencing IPV was associated with an increased risk of invasive cervical cancer (adjusted relative risk [aRR] 5 4.28; 95% CI 1.94, 18.39) and with preinvasive cervical neoplasia (aRR 5 1.47; 95% CI 1.16, 1.82). This association was stronger for women experiencing physical or sexual IPV than for women experiencing psychological IPV. Women with cervical cancer reported being in violent relationships longer and experiencing more frequent physical and sexual assaults and more IPV-associated injuries than did controls. This exploratory study suggests that IPV may increase a woman's risk of cervical neoplasia. The mechanism by which IPV effects cervical neoplasia may be indirect through psychosocial stress or negative coping behaviors or direct through sexual assaults and transmission of human papillomavirus (HPV). 1015

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Section: Discussionsupporting

confidence: 88%

Intimate Partner Violence and Cervical Neoplasia

Coker

Sanderson

Fadden

et al. 2000

Journal of Women's Health & Gender-Based Medicine

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“…No HPV DNA-positive sample was found. Our results indicate that transmission of genital HPV infection via floor or seat surfaces on the above premises is highly unlikely (Puranen et al, 1996b). (4.2) SEXUAL ABUSE In contrast to the unequivocal data on sexual transmission of genital warts in adults and sexually active adolescents, reports on the primary mode of transmission of genital warts in children have been more contradictory (Gutman et al, 1992). In children, the issue of genital warts originating from sexual abuse was raised in the 1980s, when vulvar condylomata in young children, previously considered extremely rare, were reported with increasing frequency (Stumpf, 1980).…”

mentioning

confidence: 57%

“…The full extent of the complex problems posed by genital warts in small children was fully appreciated only in the early 1990s. Crit Rev Oral Biol Med ic assessment of other sexually transmitted diseases (STDs), and (4) age-adjusted interviews of the child and caretakers by skilled personnel (Gutman et al, 1992(Gutman et al, , 1994 (Cook et al, 1973;Strong et al, 1976;Quick et al, 1980;Hallden and Majmudar, 1986;Abramson et al, 1987). Recently, a case of laryngeal papilloma was reported in a one-year-old child delivered vaginally (Alberico et al, 1995).…”

mentioning

confidence: 99%

Human Papillomavirus Infections in Children: the Potential Role of Maternal Transmission

Syrjänen¹,

Puranen

2000

Critical Reviews in Oral Biology & Medicine

217

213

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To date, more than 100 types of human papillomavirus (HPV) have been identified. In the past 20 years, there has been an increasing interest in HPVs because of their potential role in the pathogenesis of malignant tumors. HPV infections are known to affect predominantly adult, sexually active age groups, whereas skin warts, at various anatomic sites, are usually associated with younger individuals. The modes of viral transmission in children remain controversial, including perinatal transmission, auto-and hetero-inoculation, sexual abuse, and, possibly, indirect transmission via fomites. Recent studies on perinatal infection with HPV have been inconclusive. It is still unclear how frequently perinatal infection progresses to clinical lesions, whether genital, laryngeal, or oral. Conflicting reports have been published on the prevalence of HPV infections in children. The current consensus is, however, that newborn babies can be exposed to cervical HPV infection of the mother. The detection rate of HPV DNA in oral swabs of newborn babies varies from 4% to 87%. The concordance of HPV types detected in newborn babies and their mothers is in the range of 57% to 69%, indicating that the infants might acquire the HPV infection post-natally from a variety of sources. HPV antibodies have been detected in 10% to 57% of the children, and there is usually no correlation between seropositivity and the detection of HPV DNA in either the oral or the genital mucosa. There is also evidence that transmission in utero or post-natal acquisition is possible. The mode of in utero transmission remains unknown, but theoretically the virus could be acquired hematogenously, by semen at fertilization, or as an ascending infection in the mother. The understanding of viral transmission routes is important, particularly because several vaccination programs are being planned worldwide. The serologic response to HPV detected in different populations of young women or women at risk of cervical cancer might be due to genital infections, but the possibility that HPV infection has been acquired earlier in life through the oral mucosa or respiratory tract cannot be ruled out.

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“…Due to the possibility that children with external genital warts may have been sexually abused, communication with the relevant child protection agency is indicated if there is a strong suspicion of abuse based on the patient's history and physical examination. 9 Treatment of lesions resulting from HPV should be individualized. Various sessions with different therapeutic modalities may be required to achieve complete regression of the lesions.…”

Section: Discussionmentioning

confidence: 99%

Tratamento do papiloma vírus humano na infância com creme de imiquimode a 5%

Brandt

Fernandes

Patriota

et al. 2010

An. Bras. Dermatol.

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Abstract:In children, lesions caused by the human papillomavirus (HPV) constitute a significant epidemiological issue and a therapeutic dilemma, particularly in the case of anogenital warts. The treatment of anogenital warts in children is a challenge, since standard treatments are generally painful and require the patient to be anesthetized. Imiquimod, a topical immune response modifier, constitutes an alternative therapeutic agent for the treatment of HPV. The present report describes four cases in which treatment with topically applied imiquimod 5% cream was implemented with successful results. Keywords: Aminoquinolines; Human papillomavirus 6; Human papillomavirus 11; Interferon inducers; Papillomavirus infections Resumo: Lesões decorrentes da infecção pelo papilomavírus humano na infância, em especial as verrugas anogenitais, são um importante problema epidemiológico e terapêutico. O tratamento das verrugas anogenitais na infância é um desafio terapêutico. Os tratamentos convencionais geralmente são dolorosos e necessitam de anestesia geral. O imiquimode, um imunomodulador tópico, constitui uma alternativa terapêutica. Serão descritos quatro casos tratados com sucesso utilizando creme de imiquimode a 5% aplicado topicamente.

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Evaluation of Sexually Abused and Nonabused Young Girls for Intravaginal Human Papillomavirus Infection

Cited by 33 publications

References 33 publications

Intimate Partner Violence and Cervical Neoplasia

Intimate Partner Violence and Cervical Neoplasia

Human Papillomavirus Infections in Children: the Potential Role of Maternal Transmission

Tratamento do papiloma vírus humano na infância com creme de imiquimode a 5%

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