Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients

Ma, Ling; Xie, Wen; Li, Danyang; Shi, Lei; Ye, Guangming; Mao, Yanhong; Xiong, Yao; Sun, Hui; Zheng, Fang; Chen, Zhimin; Qin, Jyuling; Lyu, Jing; Zhang, Yuanzhen; Zhang, Ming

doi:10.1002/jmv.26259

Cited by 254 publications

(386 citation statements)

References 25 publications

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“…They found a non-signifi cant trend of testosterone levels to be lower in COVID-19 patients compared with control subjects, median (interquartile range) being 397 (312-568) and 479 (349-562) ng/dl, respectively (P=0.094) [12]. Meanwhile luteinizing hormone (LH) values were signifi cantly higher in patients compared with control individuals; median 5.9 (4.3-8.2) and 3.2 (2.5-4.6) mU/L, respectively, P < 0.0001) [12]. It follows that the testosterone/LH ratio, a marker of testicular function, was signifi cantly lower in patients with COVID-19 compared with healthy subjects [12].…”

Section: Male Studiesmentioning

confidence: 97%

“…Meanwhile luteinizing hormone (LH) values were signifi cantly higher in patients compared with control individuals; median 5.9 (4.3-8.2) and 3.2 (2.5-4.6) mU/L, respectively, P < 0.0001) [12]. It follows that the testosterone/LH ratio, a marker of testicular function, was signifi cantly lower in patients with COVID-19 compared with healthy subjects [12]. This observation suggests some degree of testicular dysfunction in men with COVID-19.…”

Section: Male Studiesmentioning

confidence: 99%

“…In one Chinese retrospective study, Ma, et al [12] compared serum levels of testosterone in 81 young men (median age 38 years) hospitalized for COVID-19 (86% of them had moderate disease) with 100 healthy control subjects. They found a non-signifi cant trend of testosterone levels to be lower in COVID-19 patients compared with control subjects, median (interquartile range) being 397 (312-568) and 479 (349-562) ng/dl, respectively (P=0.094) [12]. Meanwhile luteinizing hormone (LH) values were signifi cantly higher in patients compared with control individuals; median 5.9 (4.3-8.2) and 3.2 (2.5-4.6) mU/L, respectively, P < 0.0001) [12].…”

Section: Male Studiesmentioning

confidence: 99%

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Clinical significance of sex hormones in COVID-19

Mikhail¹,

Wali²

2020

J Gynecol Res Obstet

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80-89 and 90+ age groups. Ding, et al. [4] have shown that sex differences in COVID-19 severity and mortality may depend on menopausal status. Thus, they did not fi nd differences in disease severity and clinical outcomes when comparing post-menopausal women with age-matched men [4]. Yet, signifi cant differences existed between pre-menopausal women and age-matched men, with fewer pre-menopausal women suffering severe form of COVID-19 (46% versus 75% in men, P <0.01), and death (0% versus 9.7% in men, P <0.01) [4]. These results suggest that pre-menopausal state may have protective effect against COVID-19. Most researchers believe that excess mortality in men relative to women is largely due to higher prevalence of smoking, cardiovascular and lung disease co-morbidities [5]. Using a multinational registry formed of 14,712 patients with COVID-19, Alkhouli, et al. [5] found that all-cause mortality was 8.8% in men and 4.3% in

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Section: Male Studiesmentioning

confidence: 97%

Section: Male Studiesmentioning

confidence: 99%

Section: Male Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Clinical significance of sex hormones in COVID-19

Mikhail¹,

Wali²

2020

J Gynecol Res Obstet

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“…One retrospective study provided the first evidence regarding the alteration of sex-related hormones under COVID-19. After comparing follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin, anti-Mullerian hormone AMH and oestradiol (E 2 ) levels in CoVID-19 and fertile control men, they found a significant increase of LH levels and a decreased T:LH ratio, suggesting an impairment in the steroidogenic function of the testis [ 149 ].…”

Section: Sars-cov-2 Detection In the Reproductive System And Effecmentioning

confidence: 99%

Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving?

et al. 2020

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The current knowledge concerning the connection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the renin–angiotensin system (RAS) system in the male reproductive apparatus is still limited, so dedicated studies are urgently required. Concerns about the male fertility consequences of SARS-CoV-2 infection have started to emerge, since epidemiologic studies observed that this coronavirus affects male patients more frequently and with increased severity, possibly because of the hormone-regulated expression of angiotensin-converting enzyme 2 (ACE2) receptor. A disturbance in fertility is also expected based on studies of the previous SARS-CoV infection, which targets the same ACE2 receptor when entering the host cells. In addition, bioinformatics analyses reveal the abundant expression of ACE2 receptor in the male reproductive tissues, particularly in the testis. It has been proposed that pharmacological intervention favoring the angiotensin-(1–7)/ACE2/Mas receptor pathway and increasing ACE2 expression and activity could greatly prevent inflammatory lesions in this area. Finally, in laboratories performing assisted reproductive technologies it is recommended that more attention should be paid not only to sperm quality but also to safety aspects. Data about the potential infectivity of seminal fluid are in fact conflicting and do not exclude risks for both personnel and patients. The potential infectivity of SARS-CoV-2 in reproductive male tissues should be strongly considered and further investigated for the proper management of in vitro fertilization procedures.

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“…Serum testosterone:luteinizing hormone ratio showed significant inverse association with C-reactive protein as well. 55 This suggests a testicular pathology, which may be inflammatory in character. Besides elaboration of the role of ACE2 and TMPRSS2 in facilitating entry of the virus into the cell and their intricate relation to androgen pathway, they may also unravel newer pathophysiological links and therapeutic opportunities.…”

Section: Testosterone As a Friendmentioning

confidence: 99%