Evaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compounds

Gürlek, Ceren; Yarkent, Çağla; Köse, Ayşe; Oral, İzel; Öncel, Suphi Ş.; Elibol, Murat

doi:10.1007/978-3-030-17971-7_41

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…However, the role of phenolic compounds as antioxidants in microalgae remains unknown. Gürlek et al evaluated the antioxidant activity of a number of phenolic compounds obtained from Galderia sulphuraria, Neochloris texensis, Stichococcus bacillaris, Ettlia carotinosa, Chlorella minutissima, Schizochytrium limacinum, Crypthecodinium cohnii and Chlorella vulgaris microalgae extracts [ 3 ]. The maximum antioxidant activity and the content of phenolic compounds were detected in the Galderia sulphuraria extract.…”

Section: The Biological Activity Of Various Substances From Microamentioning

confidence: 99%

“…Microalgae are rich in nutrients and biologically active substances, such as proteins, polysaccharides, lipids, polyunsaturated fatty acids, vitamins, pigments, phycobiliproteins, enzymes, etc. Biologically active substances from microalgae are capable of exhibiting antioxidant, antibacterial, antiviral, antitumor, regenerative, antihypertensive, neuroprotective and immunostimulating effects [ 3 ]. These compounds are in demand in pharmacology, medicine, cosmetology, the chemical industry, fish farming, the energy industry, agriculture in the production of feed and functional foods [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Microalgae: A Promising Source of Valuable Bioproducts

et al. 2020

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Microalgae are a group of autotrophic microorganisms that live in marine, freshwater and soil ecosystems and produce organic substances in the process of photosynthesis. Due to their high metabolic flexibility, adaptation to various cultivation conditions as well as the possibility of rapid growth, the number of studies on their use as a source of biologically valuable products is growing rapidly. Currently, integrated technologies for the cultivation of microalgae aiming to isolate various biologically active substances from biomass to increase the profitability of algae production are being sought. To implement this kind of development, the high productivity of industrial cultivation systems must be accompanied by the ability to control the biosynthesis of biologically valuable compounds in conditions of intensive culture growth. The review considers the main factors (temperature, pH, component composition, etc.) that affect the biomass growth process and the biologically active substance synthesis in microalgae. The advantages and disadvantages of existing cultivation methods are outlined. An analysis of various methods for the isolation and overproduction of the main biologically active substances of microalgae (proteins, lipids, polysaccharides, pigments and vitamins) is presented and new technologies and approaches aimed at using microalgae as promising ingredients in value-added products are considered.

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Section: The Biological Activity Of Various Substances From Microamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microalgae: A Promising Source of Valuable Bioproducts

et al. 2020

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“…In these assays, first step is cultivation of the selected animal cell culture to obtain enough amount of them for analyzation. At this point, cell lines named Vero, 4T1, MCF-7, MCF-10A, MDA-MB-231, HepG2 or B16F10 can be used [79][80][81][82]. After that, the cell culture is treated with different concentration of squalene and incubated.…”

Section: Extraction and Quantification Of Squalene From Microalgal Bi...mentioning

confidence: 99%

“…For this purpose, 2,2diphenyl-1-picrylhydrazyl hydrate free radical method can be selected as a method which gives the information about its antioxidant activity. This simple method is based on detecting the sample's color changes by UV detector at 517 nm [79]. More detailed, it is known that microalgae produce antioxidants when exposed to stress conditions that caused by switching to an unsuitable range in the parameters required for their growth.…”

Section: Extraction and Quantification Of Squalene From Microalgal Bi...mentioning

confidence: 99%

Recent Progress in Microalgal Squalene Production and Its Cosmetic Application

Yarkent

Öncel

2022

Biotechnol Bioproc E

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Squalene, [oxidized form squalane] is a terpenoid with biological activity that produced by animals and plants. In the human body, a significant excretion named as sebum includes squalene in 12 percent. This bioactive compound shows anti-inflammatory, detoxifying, moisturizing and antioxidant effects on the human body. In addition to having these properties, it is known that squalene production decreases as less sebum is produced with age. Because of that, the need for supplementation of squalene through products has arisen. As a result, squalene production has been drawn attention due to its many application possibilities by cosmetic, cosmeceutical and pharmaceutical fields. At this point, approximately 3,000 of sharks, the major and the most popular source of squalene must be killed to obtain 1 ton of squalene. These animals are on the verge of extinction. This situation has caused to focus on finding microalgae strains, which are sustainable producers of squalene as alternative to sharks. This review paper summarizes the recent progresses in the topic of squalene. For this purpose, it contains information on squalene producers, microalgal squalene production and cosmetic evaluation of squalene.

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“…These problems are indicated in the global predictive model of the Club of Rome [1,2]. The problem of food is determined by the concept of functional nutrition [3,4]. An important task in this concept is the safety of products [5], their high quality.…”

Section: Introductionmentioning

confidence: 99%

Experimental Modeling of Process of Water Solutions Evaporation in the Vacuum and Microwave Field Conditions

Burdo¹,

Mordynskiy²,

Gavrilov³

et al. 2019

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A comparative analysis of traditional methods for the food solutions concentration is given. The main problem of classical evaporators is identified, which is associated with the impossibility of obtaining high concentrations of the finished product due to a sharp increase in its viscosity and temperature through the formation of a boundary layer. A scientific and technical hypothesis has been formulated, representing a possible solution to this problem by providing a volume supply of energy directly to the moisture of the product. Thermophysical scheme of evaporation processes by traditional and innovative methods is considered. Their fundamental differences are highlighted and the relevance of the development of an innovative evaporation method is substantiated. The scheme of the innovative evaporator is presented, which allows to obtain the finished product in the solid phase with a final concentration of up to 90 °brix. By the example of apple juice, experiments were conducted to study the effect of pressure of the electromagnetic field on the steam output of the apparatus. Dependencies that indicate a constant evaporation rate throughout the entire process, up to a concentration of 80-85 °brix, were built. The product temperature did not exceed 35-40 °C, which may indicate its high nutritional value. The above data confirm the formulated hypothesis about the possibility of transition in the process of evaporation from the boundary conditions of the 3rd type to the boundary conditions of the 2nd type by the using microwave energy. On the basis of the obtained results, a model in the criterial form was obtained, which makes it possible to accurately calculate the performance of a microwave vacuum evaporator in certain ranges of the number of energetic action and the obtained dimensionless complex.

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Evaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compounds

Cited by 8 publications

References 19 publications

Microalgae: A Promising Source of Valuable Bioproducts

Microalgae: A Promising Source of Valuable Bioproducts

Recent Progress in Microalgal Squalene Production and Its Cosmetic Application

Experimental Modeling of Process of Water Solutions Evaporation in the Vacuum and Microwave Field Conditions

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