Evaluation of seven tumor markers (CA 50, CA 19-9, CA 19-9 TruQuant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of patients with gastric carcinoma

Wobbes, Theo; Thomas, C.; Segers, M. F. G.; Nagengast, F. M.

doi:10.1002/1097-0142(19920415)69:8<2036::aid-cncr2820690805>3.0.co;2-m

Cited by 55 publications

(28 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to these investigators a weak correlation was found with CA19.9 positivity and tumor location .No correlation existed between CA19.9 positivity, age, tumor size, histological type, lymph node, hepatic and peritoneal metastasis (2). Wobbs et al (3) have compared the levels of CA19.9 with stages of the gastric cancer. In patients of stage IV gastric carcinoma CA19.9 levels as high as 2300 U/ml have been reported.…”

supporting

confidence: 87%

“…Its levels correlate well with pancreatic cancer staging.80% of patients with pancreatic carcinoma, 67% of hepatobiliary, 40-50% of gastric carcinoma patients show high CA 19.9 (>37U/L). Raised levels of this marker in gastric carcinoma has also been reported by various investigators (3,5,6). Yamao et al (7) have shown elevation of CA 19.9 levels in 26 patients of gastric carcinoma with mean value of 163 U/ mL range being (53.8-873.5).…”

mentioning

confidence: 53%

See 1 more Smart Citation

Unusually high serum CA19.9 in gastric carcinoma: A case report

Thakur

Mukherjee

2008

Indian J Clin Biochem

View full text Add to dashboard Cite

We describe a case of poorly differentiated adenocarcinoma of stomach, which did not present typical symptoms of gastrointestinal malignancy on first visit. The patient, a 62 year old smoker presented with shortness of breathe and pain in right lumbar region with no history of fever. Bone scans revealed multiple hot spots in skull, sternum, lumbar vertebrae and both iliac crests. A series of tumor markers were ordered which include PSA, CEA, CA19.9, CA 72.4 and AFP. Serum PSA and AFP concentrations were within normal range. Serum CEA and CA 72.4 were raised significantly. Markedly elevated levels of serum CA19.9 were found (>45000 U/ ml) in this patient. CT chest and bronchoscopic examination ruled out the possibility of cancer lung. Upper GI tract endoscopy was done to find out lesion in GI tract. An ulcerative lesion was found in lesser curvature of stomach. Histopathological examination of endoscopic biopsy revealed a poorly differentiated adenocarcinoma of stomach. An unusually high serum CA19.9 (>45000U/ml) in case of gastric carcinoma has not been reported earlier.

show abstract

supporting

confidence: 87%

mentioning

confidence: 53%

Unusually high serum CA19.9 in gastric carcinoma: A case report

Thakur

Mukherjee

2008

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Particularly in patients with stage II or stage III gastric cancer, there was a significant difference between HGF CAl9-9 and CA125. Recently, various tumour markers for gastric cancer were reported from many clinical institutes, including CA72-4, TPA and CA50 (Guadagni et al, 1992;Wobbes et al, 1992). However, after a review of the literature, the measurement of serum HGF levels seems to be the most sensitive method for monitoring tumour progression in gastric cancer.…”

Section: Discussionmentioning

confidence: 54%

Increase in the circulating level of hepatocyte growth factor in gastric cancer patients

Taniguchi

Kitamura²,

Arai³

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

Summary We measured serum concentrations of hapatocyte growth factor (HGF) in patients with gastric cancer and compared these with the histological findings and conventional tumour markers, including CEA, CA19-9 and CA125, for evaluation of the significance of serum HGF levels as a tumour marker. The HGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) system. The average levels of serum HGF in 89 healthy control subjects, 104 patients with primary gastric cancer and 15 patients with recurrent gastric cancer were 0.31 ± 0.11 ng ml-1, 0.42 ± 0.50 ng ml-1 and 0.92 ± 0.39 ng mi-1 respectively. The average level in patients with recurrent disease was significantly higher than in healthy control subjects and in primary cancer patients (P< 0.001 and P< 0.003 respectively). Of 104 patients with primary gastric cancer, 35 (33.7%) showed an aberrant increase in the circulating level of HGF. The increased HGF levels were significantly associated with the degrees of histological tumour invasion and venous invasion. Of 15 patients with recurrent gastric cancer, 14 (93.3%) showed an aberrant increase. No correlation was found between serum HGF levels and CEA levels, CA19-9 levels and CA125 levels. However, the rate of the aberrant increase in HGF levels was significantly higher than that of any other tumour markers, including CEA, CAl 9-9 and CAl 25, in primary gastric cancer patients. In conclusion, the circulating levels of HGF were elevated in approximately one-third of patients with primary gastric cancer, particularly in those with high grades of histological tumour invasion and venous invasion, and frequently in patients with distant metastases, suggesting that HGF might play important roles in the tumour progression of gastric cancer. Furthermore, serum HGF levels may be of value as a tumour marker in patients with gastric cancer.

show abstract

“…A large number of studies on the potential diagnostic value of pleural tumor markers have been published, which report either encouraging or disappointing results (Wobbes et al, 1992;Garcia-Pachon et al, 1997;Riantawan et al, 2000;Paganuzzi et al, 2001). The disagreement in results can be attributed to different factors, including the heterogeneity of tumor types, the appropriate inclusion of paramalignant PE to calculate test performances, the sometimes underpowered series, and the use of different methodologies and cut-off values in tumor marker assays (Porcel et al, 2004).…”

Section: Discussionmentioning

confidence: 99%