Evaluation of serum procalcitonin and interleukin-6 levels as markers of liver metastasis

Matzaraki, Vassiliki; Alexandraki, Krystallenia Ι.; Venetsanou, Kyriaki; Piperi, Christina; Myrianthefs, Pavlos; Malamos, Nikolaos; Giannakakis, T.; Karatzas, Stelios; Diamanti-Kandarakis, Evanthia; Baltopoulos, George

doi:10.1016/j.clinbiochem.2006.10.027

Cited by 54 publications

(49 citation statements)

References 46 publications

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“…Ghillani et al 31 previously reported that calcitonin precursors were frequently elevated in patients with various malignant tumors, ranging from 7% in breast tumors to 62% in hepatocellular carcinoma, depending on the cell type and tumor stage. These results were confirmed by Matzaraki et al 32 in a study that included 43 patients with solid tumors and no evidence of infection. PCT was shown to be a marker of metastatic disease, because serum PCT levels in patients with generalized metastatic carcinoma were significantly higher than those in healthy control subjects and cancer control patients without metastasis.…”

Section: Original Article 5826supporting

confidence: 79%

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Shomali

Hachem

Chaftari

et al. 2012

Cancer

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BACKGROUND: Procalcitonin (PCT) has been proposed as a marker of infection and was studied in neutropenic patients. This study investigated its role in non‐neutropenic febrile cancer patients (NNCPs). METHODS: Between July 2009 and July 2010, a total of 248 NNCPs with fever were studied. PCT was measured in plasma within 24 hours of fever onset and 4 to 7 days thereafter, using a Kryptor system with a lower limit of quantitation of 0.075 ng/mL. Patients' clinical, microbiological, and radiological data were reviewed to make the diagnosis and were correlated with PCT levels. RESULTS: This study included 30 patients with bloodstream infection (BSI), 60 with localized bacterial infection, 141 with no documented infection, and 8 with tumor‐related fever. Most patients (98%) were inpatients or admitted to the hospital during the study. Patients with BSI had significantly higher PCT levels than did those with documented localized infections (P = .048) and no documented infection (P = .011). PCT levels were significantly higher in septic patients than in those without sepsis (P = .012). Patients with stage IV disease or metastasis had significantly higher baseline PCT levels than did those with early stages of cancer (P < .05). PCT levels dropped significantly in patients with bacterial infections in response to antibiotics (P < .0001). CONCLUSIONS: Baseline PCT levels are predictive of BSI and sepsis in NNCPs. They may be predictors of metastasis and advanced cancer. Subsequent decrease in PCT levels in response to antibiotics is suggestive of bacterial infection. Larger trials are needed to confirm the results of this pilot study. Cancer 2012. © 2012 American Cancer Society.

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Section: Original Article 5826supporting

confidence: 79%

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Shomali

Hachem

Chaftari

et al. 2012

Cancer

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“…It has been reported that IL-6 is a critical regulator in liver metastasis (Matzaraki et al, 2007;Maeda et al, 2009). Our results showed that increased IL-6, when stimulated by DEN, was suppressed by SJSZ glycoprotein (Figure 6).…”

Section: Discussionsupporting

confidence: 57%

Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice

Liu

Lim

2011

Drug and Chemical Toxicology

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Metastasis is one of the major causes of cancer-associated mortality. Aberrant expression of matrix metalloproteinase-9 (MMP-9) has been implicated in the metastasis of various cancer cells. The aim of this study was to investigate the inhibitory effect of a glycoprotein (38 kDa) isolated from Styrax japonica Siebold et al Zuccarini (SJSZ) on metastasis of hepatocellular carcinoma (HCC) in diethylnitrosamine (DEN)-treated imprinting control region (ICR) mice. To study the chemopreventive effect of SJSZ glycoprotein on the metastasis of HCC, ICR mice were injected intraperitoneally with DEN (75 mg/kg) for 11 weeks. Subsequently, we evaluated nitric oxide (NO), alpha-fetoprotein (AFP), activator protein (AP)-1, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), matrix metalloproteinase (MMP)-9, and interleukin (IL)-6 using biochemical reaction, immunoblot analysis, and reverse-transcription polymerase chain reaction. Here, the results showed that SJSZ glycoprotein (10 mg/kg body weight) reduced the production of NO in DEN (75 mg/kg)-treated ICR mice. Also, it suppressed the activity of AFP, AP-1 (c-Jun and c-Fos), COX-2, iNOS, and MMP-9. Taken together, SJSZ glycoprotein inhibits the activity of MMP-9 as a metastasis factor.

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“…The patients with neuroendocrine tumors or follicular-cell derived thyroid carcinomas, who had elevated PCT levels, had liver, lung, and lymph node metastasis, respectively. Recently it has been suggested that PCT might serve as an early indicator of metastatic disease (19). Further studies might be warranted to establish the utility of PCT, if any, as a general marker of cancer metastasis.…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin: A Marker for the Diagnosis and Follow-Up of Patients with Medullary Thyroid Carcinoma

Algeciras‐Schimnich

Preissner

Theobald

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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Evaluation of serum procalcitonin and interleukin-6 levels as markers of liver metastasis

Cited by 54 publications

References 46 publications

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice

Procalcitonin: A Marker for the Diagnosis and Follow-Up of Patients with Medullary Thyroid Carcinoma

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