Evaluation of serum lipid profile of under-five Nigerian children

Akuyam, SA; Isah, HS; Ogala, WN

doi:10.4103/1596-3519.55722

Cited by 15 publications

(10 citation statements)

References 13 publications

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“…Lipid profile became a useful parameter through its use in the diagnosis of several cardiovascular diseases and control of diabetic patients [9]. The results of our study showed a significant increase in TC (+36.4%), TG (+44.9%) and LDL-C (+53.37%) associated with a remarkable decrease in HDL-C (-15.16%) in diabetic rats.…”

Section: Glycemia and Lipid Profilesupporting

confidence: 50%

Therapeutic Effect of Zygophyllum cornutum on Metabolic Disturbances, Oxidative Stress in Heart Tissue and Histological Changes in Myocardium of Streptozotocin-induced Diabetic Rats

Boumaza¹,

Ferdi²,

Sbayou³

et al. 2016

JLS

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Abstract:The present study depicts the therapeutic effect of Zygophyllum cornutum methanolic extract (ZCME) on metabolic disturbances, oxidative stress in heart and myocardium histological changes in streptozotocin (STZ)-induced diabetic rats. Three days after diabetes induction, ZCME was administered orally for six weeks (700 mg/kg bw/day). Serum glucose and lipid profile were evaluated. Reduced glutathione (GSH), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) were measured in heart tissue. The results showed increased levels of blood glucose, total cholesterol (TC), LDL cholesterol (LDL-C) and triglyceride (TG) in the diabetic rats. On the other hand, the level of HDL cholesterol (HDL-C) decreased. Compared to the control normal rats, the level of TBARS in heart tissue was markedly increased while GSH and CAT were significantly modified in the diabetic rats. Oral administration of ZCME has normalized serum glucose and lipid profile. TBARS were significantly reduced in heart while CAT and GSH were markedly normalized. Myocardium sections showed the absence of histological changes observed in the diabetic rats. The study suggests that Zygophyllum cornutum may provide a useful therapeutic option in the reversal of metabolic disturbances and oxidative stress-induced cardiac dysfunction in diabetes mellitus.

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Section: Glycemia and Lipid Profilesupporting

confidence: 50%

Therapeutic Effect of Zygophyllum cornutum on Metabolic Disturbances, Oxidative Stress in Heart Tissue and Histological Changes in Myocardium of Streptozotocin-induced Diabetic Rats

Boumaza¹,

Ferdi²,

Sbayou³

et al. 2016

JLS

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“…Data on normal lipid profiles in children <2 years of age are lacking. Children in the US may have higher cholesterol levels than children in Africa (20). Genetic, environmental, and dietary factors likely play a role in lipid metabolism and it is unclear whether US standards are applicable for monitoring HIV- and HAART-associated dyslipidemia in African infants.…”

mentioning

confidence: 99%

Lipid Changes in Kenyan HIV-1–infected Infants Initiating Highly Active Antiretroviral Therapy by 1 Year of Age

Langat

Benki-Nugent²,

Wamalwa

et al. 2013

Pediatric Infectious Disease Journal

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Background Early highly active antiretroviral therapy (HAART) is recommended for HIV-1 infected infants. There are limited data on lipid changes during infant HAART. Methods Non-fasting total (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL) cholesterol, and triglycerides (TG) were measured at 0, 6 and 12 months. Correlates of lipid levels and changes post-HAART were assessed using linear regression. Results Among 115 infants, pre-HAART median age was 3.8 months, CD4% was 19%, and weight-for-age z-score (WAZ) was −2.42. Pre-HAART median lipid levels were: TC, 108.7 mg/dl, LDL, 42.5 mg/dl, HDL, 29.4 mg/dl and TG, 186.9 mg/dl. Few infants had abnormally high TC (6.2%) or LDL (5.6%), but many had low HDL (76.5%) or high TG (69.6%). Higher pre-HAART WAZ and HAZ were each associated with higher pre-HAART TC (P=0.04 and P=0.01) and LDL (P=0.02 and P=0.008). From 0–6 months post-HAART, TC (P<0.0001), LDL (P<0.0001), and HDL (P<0.0001) increased significantly, and 23.1% (P=0.002), 14.0% (P=0.2), 31.3% (P<0.0001), and 50.8% (P=0.2) of infants had abnormally high TC, high LDL, low HDL, and high TG, respectively. Changes in TC and HDL were each associated with higher gain in WAZ (P=0.03 and P=0.01) and HAZ (P=0.01 and P=0.007). Increased change in LDL was associated with higher gain in HAZ (P=0.03). Infants on protease inhibitor (PI)-HAART had smaller HDL increase (P=0.004). Conclusions Infants had substantive increases in lipids, which correlated with growth. Increases in HDL were attenuated by PI-HAART. It is important to determine clinical implications of these changes.

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“…Lipid profile is of crucial importance in the diagnosis and treatment of several cardiovascular diseases and control of diabetic patients [23]. Studies have reported that cardiovascular complications associated with diabetes are due to disturbances of lipid metabolism [24].…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that the production of ROS and lipid peroxidation are increased in diabetic patients and that oxidative stress is responsible for the pathophysiology of diabetes [23], especially, that associated with antioxidant treatment showed significant improvement and prevention against cardiovascular complications [25].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity of Plumeria Alba Linn (Apocynaceae) Root Extract and Fractions in Streptozotocin-Induced Diabetic Rats

Kadébé¹,

Metowogo²,

Bakoma³

et al. 2016

Trop. J. Pharm Res

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Evaluation of serum lipid profile of under-five Nigerian children

Cited by 15 publications

References 13 publications

Therapeutic Effect of Zygophyllum cornutum on Metabolic Disturbances, Oxidative Stress in Heart Tissue and Histological Changes in Myocardium of Streptozotocin-induced Diabetic Rats

Therapeutic Effect of Zygophyllum cornutum on Metabolic Disturbances, Oxidative Stress in Heart Tissue and Histological Changes in Myocardium of Streptozotocin-induced Diabetic Rats

Lipid Changes in Kenyan HIV-1–infected Infants Initiating Highly Active Antiretroviral Therapy by 1 Year of Age

Antidiabetic Activity of Plumeria Alba Linn (Apocynaceae) Root Extract and Fractions in Streptozotocin-Induced Diabetic Rats

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