Evaluation of serum levels of IL-9 and IL-17 in human Schistosoma mansoni infection and their relationship with periportal fibrosis

Barreto, Ana Virgínia Matos Sá; Lacerda, Glaucia Alyne Nunes de; Figueiredo, Anna Lígia de Castro; Diniz, George Tadeu Nunes; Gomes, Elainne Christine de Souza; Domingues, Ana Lúcia Coutinho; Barbosa, Constança Simões; Montengro, Silvia Maria Lucena; Morais, Clarice Neuenschwander Lins de

doi:10.1016/j.imbio.2016.07.014

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…Similarly, aberrant expression of cytokine interleukin 9 was found along with interleukin 4 and interferon γ in connective tissue disease-associated interstitial lung disease (association with severity of pulmonary fibrosis) 29 . Serum levels of IL-9 cytokine showed no significant differences ( p > 0.05) between chronic clinical forms of Schistosoma mansoni infection disease, and in comparisons with the different classifications of periportal fibrosis 30 .…”

Section: Discussionmentioning

confidence: 77%

Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver

Xie

Wang

et al. 2017

Sci Rep

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Liver granulomatous inflammation and fibrosis were the primary pathological changes observed during Schistosoma japonicum (S. japonicum) infection. In the present study, the characteristics of IL-9 were investigated in the liver of S. japonicum infection C57BL/6 mice. Immunofluorescence, qRT-PCR, and ELISA results demonstrated that the expression of IL-9 significantly increased after infection (P < 0.01). FACS results indicated that the peak of IL-9+ Th9 cells in the liver mononuclear cells appeared at the early phase of infection (week 5), except that Th9 cells, CD8+ Tc cells, NKT and γδT cells could secrete IL-9 in this model. Although IL-9 neutralization has a limited effect on liver granulomatous inflammation, it could decrease the level of fibrosis-associated factor, PC-III, in the serum of infected mice (P < 0.05). Taken together, our results indicated that IL-9 was an important type of cytokine involved in the progression of S. japonicum infection-induced hepatic damage.

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Section: Discussionmentioning

confidence: 77%

Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver

Xie

Wang

et al. 2017

Sci Rep

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“…in transgenic mice compared to just 7% in wild‐type mice 88 . Nevertheless, in human S mansoni infections, there was no observed correlation of IL‐9 levels with the level of pathology 89 . These findings suggest that Th9 cells may be involved in the immunopathology of murine schistosomiasis; however, in human infections, the picture is less clear and further studies are required to clarify its role.…”

Section: Composition Of the Granulomamentioning

confidence: 89%

Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections

Llanwarne

Helmby

2020

Parasite Immunology

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Schistosomiasis is the most important helminth disease in the world from a public health perspective. S mansoni and S japonicum account for the majority of global intestinal schistosomiasis cases, and the pathogenesis is widely assumed to be fundamentally similar. However, the majority of research on schistosomiasis has been carried out on S mansoni and comparisons between the two species are rarely made. Here, we will discuss aspects of both older and recent literature where such comparisons have been made, with a particular focus on the pathological agent, the host granulomatous response to the egg. Major differences between the two species are apparent in features such as egg production patterns and cellular infiltration; however, it is also clear that even subtle differences in the cascade of various cytokines and chemokines contribute to the different levels of pathology observed between these two main species of intestinal schistosomiasis. A better understanding of such differences at species level will be vital when it comes to the development of new treatment strategies and vaccines.

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“…Pleiotropic cytokine IL-9 activates various target cells including dendritic cells, mast cells, and CD8 + T cells, and is involved in the pathological processes of multiple diseases including inflammatory diseases, infectious diseases, autoimmune diseases, and cancer ( 93 – 95 ). Elevated serum IL-9 levels have been reported in patients with periportal fibrosis caused by Schistosoma mansoni infection ( 96 ). In both the silica-induced lung fibrosis mouse model and human patients with idiopathic pulmonary fibrosis (IPF) and cystic fibrosis, IL-9 levels were found to be correspondingly elevated ( 51 , 53 ).…”

Section: The Role and Mechanisms Of T Cells In Fibrosis And Fibrotic mentioning

confidence: 99%

T Cells in Fibrosis and Fibrotic Diseases

2020

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Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is essential for wound healing and tissue repair in response to a variety of triggers, which include infection, inflammation, autoimmune disorder, degenerative disease, tumor, and injury. Fibrotic remodeling in various diseases, such as liver cirrhosis, pulmonary fibrosis, renal interstitial fibrosis, myocardial infarction, systemic sclerosis (SSc), and graft-versus-host disease (GVHD), can impair organ function, causing high morbidity and mortality. Both innate and adaptive immunity are involved in fibrogenesis. Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which T cells regulate fibrosis are not completely understood. The T cell receptor (TCR) engages the antigen and shapes the repertoire of antigen-specific T cells. Based on the divergent expression of surface molecules and cell functions, T cells are subdivided into natural killer T (NKT) cells, γδ T cells, CD8 + cytotoxic T lymphocytes (CTL), regulatory T (Treg) cells, T follicular regulatory (Tfr) cells, and T helper cells, including Th1, Th2, Th9, Th17, Th22, and T follicular helper (Tfh) cells. In this review, we summarize the pro-fibrotic or anti-fibrotic roles and distinct mechanisms of different T cell subsets. On reviewing the literature, we conclude that the T cell regulations are commonly disease-specific and tissue-specific. Finally, we provide perspectives on microbiota, viral infection, and metabolism, and discuss the current advancements of technologies for identifying novel targets and developing immunotherapies for intervention in fibrosis and fibrotic diseases.

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Evaluation of serum levels of IL-9 and IL-17 in human Schistosoma mansoni infection and their relationship with periportal fibrosis

Cited by 9 publications

References 17 publications

Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver

Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver

Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections

T Cells in Fibrosis and Fibrotic Diseases

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