Evaluation of Serum Level of Calprotectin in Patients with Psoriasis and Its Relation to The Clinical Severity of The Disease

Zaki, Amr Mohamed; Amer, Mohamed Abdelmawgoud; Mohamed, Nagah Mohamed Abo; Abdelkhalik, Mohamed Ahmed El-saeed

doi:10.21608/ejhm.2019.41574

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…30 Calprotectin was suggested to be a promising indicator of inflammation. 31 In agreement with previous studies, [15][16][17] we observed a significant association between increased S100A8 serum levels and severity of psoriasis. Moreover, we proposed that S100A8 serum level might be a good significant test to differentiate between grades of psoriasis severity (mild and moderate and severe cases).…”

Section: Discussionsupporting

confidence: 93%

“…As previously reported, 17 a non‐significant difference in S100A8 level between males and females cases was demonstrated. While there was a positive significant correlation between S100A8 serum level and age of the investigated patients.…”

Section: Discussionsupporting

confidence: 79%

“…Among the current selected psoriasis patients (n = 50), S100A8 serum level was significantly higher than control group (p < 0.001). In agreement with this result, Guzel et al 16 ; Zaki et al 17 and Elwan et al 18 reported significant higher concentrations of circulating calprotectin including S100A8 in patients having psoriasis than controls.…”

Section: Discussionsupporting

confidence: 63%

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S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

Farag

Shoaib

Labeeb

et al. 2022

J of Cosmetic Dermatology

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Background S100A8 single nucleotide polymorphism (SNP) and S100A8 blood level are related to many inflammatory disorders with no available conclusion in psoriasis. Aim The aim of this study was to evaluate the possible role of S100A8 in psoriasis pathogenesis through analyzing its S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients, in addition to correlate the detected results with severity psoriasis in those patients. Methods This case–control study was conducted on 50 patients having psoriasis vulgaris, and 26 controls. Severity of psoriasis was evaluated using psoriasis area and severity index (PASI) score. S100A8 serum level and S100A8 (rs3806232) SNP were evaluated by ELISA and polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) respectively. Results Serum S100A8 level was significantly higher in psoriatic patients than controls and was positively correlated with PASI score (r = 0.826, p < 0.001). S100A8 (rs3806232) AA genotype and A allele were significantly increased among psoriasis patients than controls (p < 0.001) increasing risk of psoriasis development by about 5, 12, and 6 times than AG, GG, and G alleles. AA genotype was significantly associated with psoriasis severity (p = 0.005) and high S100A8 serum levels (p = 0.018). Conclusions Circulating S100A8 could associated with disease severity and have an active role in psoriasis pathogenesis. S100A8 (rs3806232) SNP (AA genotype and A allele) might contribute to development and severity of psoriasis in the Egyptian population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 63%

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S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

Farag

Shoaib

Labeeb

et al. 2022

J of Cosmetic Dermatology

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The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

Holmannová

Borská

Andrýs

et al. 2020

Journal of Immunology Research

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Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.

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Predictive Value of Serum Calprotectin Level in Response to Treatment, a New Inflammatory Marker in Patients with Breast Cancer Requesting Neoadjuvant Treatment

BAYDAR¹,

Çelikkol²,

Gürdal³

et al. 2023

NKTD

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Evaluation of Serum Level of Calprotectin in Patients with Psoriasis and Its Relation to The Clinical Severity of The Disease

Cited by 3 publications

References 15 publications

S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

S100A8 (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary study

The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

Predictive Value of Serum Calprotectin Level in Response to Treatment, a New Inflammatory Marker in Patients with Breast Cancer Requesting Neoadjuvant Treatment

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