Evaluation of serum interleukin-1 beta as an inflammatory marker in COPD patients

Hammad, Dina R.; Elgazzar, Ahmed; Essawy, Tarek S.; Sameie, Sohair A. Abd El

doi:10.1016/j.ejcdt.2015.01.005

Cited by 16 publications

(12 citation statements)

References 14 publications

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“…This indicates an inflammatory process in the lungs of those workers. Researchers also found that interleukin-1β correlates significantly with FEV1, which draws attention to its role in clinical aspects of the disease severity (30,31) . Studies suggest that cement workers are at a greater risk of a systemic inflammatory state 17 : Cell markers, cytokines, and immune parameters in cement mason apprentices.…”

Section: Discussionmentioning

confidence: 96%

Respiratory Symptoms, Pulmonary Function and The Role of Interlukin-1Β in The Inflammatory Reaction among Workers at a Cement Factory in Cairo, Egypt

2018

The Egypt. J. of Community Medicine

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Background: Cement workers are exposed to various workplace factors that may affect their health. These health effects depend on the duration, level of exposure and individual sensitivity. Objective: The aim of the study was to determine the effect of exposure to cement dust on lung function of workers in a national cement production factory at North Cairo and to identify the possible association between such findings and interlukin-1β in addition to personal and work-related factors. Method: It included 96 workers from different departments of cement factory (exposed group) and 100 workers group from an Egyptian public institution (control group). Data collected included personal data, occupational and medical history, clinical chest examination and body mass index. Pulmonary function tests were performed to suspected 60 subjects from the exposed group and all subjects from the control group. Interleukin-1β, liver function tests and kidney function tests were measured in 67 exposed workers who agree to provide a blood sample. Results showed that cement workers and controls were matched for age, gender and smoking status. Chronic cough and expectoration were significantly higher among the exposed group. Moreover, the percentage of cement workers with reduced FEV1, FVC was significantly higher than control group. The mean work duration of the exposed group was 24 years, small percentage of workers reported wearing personal protective devices as none reported they were informed about possible hazardous exposures before starting work. Most of the participants had normal interleukin levels and normal liver and kidney function tests. However, 8.8% of cement workers have elevated serum creatinine, 23.5% have elevated blood urea nitrogen, 13.2% have elevated serum ALT and 19.1% have elevated serum AST. The current study showed a significant higher proportion of cement workers with reduced FEV1/FVC among those working for ≥ 20 years duration compared to workers with those working for < 20 years duration.

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Section: Discussionmentioning

confidence: 96%

Respiratory Symptoms, Pulmonary Function and The Role of Interlukin-1Β in The Inflammatory Reaction among Workers at a Cement Factory in Cairo, Egypt

2018

The Egypt. J. of Community Medicine

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“…The data obtained in the present study strongly suggest that no infections occurred, as levels of CRP were within the normal levels with no significant changes noticed over the course of the experimental period. IL-1β is a key member of the interleukin family, which modulates the inflammation caused by bacterial and viral infections [54]. It is mainly produced by the cells of the innate immune system.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

Al-Kasasbeh

Brady

Courtenay

et al. 2020

Drug Deliv. and Transl. Res.

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Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma skin cancers. In contrast to drug or vaccine delivery, when only a small number of MAP applications would be required, hydrogel MAPs utilised for sampling purposes or for tumour eradication would necessitate regular, repeat applications. Therefore, the current study was designed to address one of the key translational aspects of MAP development, namely patient safety. We demonstrate, for the first time in human volunteers, that repeat MAP application and wear does not lead to prolonged skin reactions or prolonged disruption of skin barrier function. Importantly, concentrations of specific systemic biomarkers of inflammation (C-reactive protein (CRP); tumour necrosis factor-α (TNF-α)); infection (interleukin-1β (IL-1β); allergy (immunoglobulin E (IgE)) and immunity (immunoglobulin G (IgG)) were all recorded over the course of this fixed study period. No biomarker concentrations above the normal, documented adult ranges were recorded over the course of the study, indicating that no systemic reactions had been initiated in volunteers. Building upon the results of this study, which serve to highlight the safety of our hydrogel MAP, we are actively working towards CE marking of our MAP technology as a medical device.

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“…Exacerbations of chronic obstructive pulmonary disease (COPD) can be triggered by bacterial airway infection and is a significant cause of human mortality. The severity of COPD is associated with expression of Siglec-14 [31]; and moreover, the level of serum IL-1β correlated with disease severity in these patients [43]. Enhanced inflammasome activation through Siglec-14 signaling may thus represent a key mechanistic link between bacterial infection and excessive inflammatory responses, such as in COPD and our studies with GBS.…”

Section: Discussionmentioning

confidence: 61%

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Tsai¹,

Riestra²,

Ali³

et al. 2019

J Innate Immun

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Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired sialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have reciprocal roles in regulating macrophage immune responses, but their interaction with IL-1β signaling and the inflammasome has not been characterized. Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1β release. Human THP-1 macrophages stably transfected with Siglec-14 exhibited increased caspase-1 activation, IL-1β release and pyroptosis after GBS infection, in a manner blocked by a specific inhibitor of nucleotide-binding domain leucine-rich repeat protein 3 (NLRP3),

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Evaluation of serum interleukin-1 beta as an inflammatory marker in COPD patients

Cited by 16 publications

References 14 publications

Respiratory Symptoms, Pulmonary Function and The Role of Interlukin-1Β in The Inflammatory Reaction among Workers at a Cement Factory in Cairo, Egypt

Respiratory Symptoms, Pulmonary Function and The Role of Interlukin-1Β in The Inflammatory Reaction among Workers at a Cement Factory in Cairo, Egypt

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

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