Evaluation of Serum Ferritin, Procalcitonin, and C-Reactive Protein for the Prediction of Severity and Mortality in Hemorrhagic Fever With Renal Syndrome

Che, Lihe; Wang, Zedong; Du, Na; Li, Liang; Zhao, Yinghua; Zhang, Kaiyu; Liu, Quan

doi:10.3389/fmicb.2022.865233

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…In metabolic syndrome, the serum ferritin levels were found to be positively related with the levels of insulin resistance, cholesterol, and triglyceride 30 . One recent study with hemorrhagic fever with renal syndrome in China revealed that the value of serum ferritin for predicting mortality was comparatively good compared with procalcitonin and C-reactive protein 31 . For all-cause mortality risk within five-year in hemodialysis patients, serum ferritin > 1500 ng/ml was an early indicator 32 .…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Guo

et al. 2023

Sci Rep

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This study aimed to investigate the relationship between serum ferritin level and prognosis in sepsis. It also explored the potential prognostic value of serum ferritin for predicting outcomes in sepsis based on a large public database. Sepsis patients in MIMIC-IV database were included. Different models including crude model (adjusted for none), model I (adjusted for age and gender) and model II (adjusted for all potential confounders) were performed. Smooth fitting curves were constructed for exploring the relationships between serum ferritin and mortalities of 28-day, 90-day, 180-day and 1-year. Receiver operator characteristic (ROC) curve analysis was utilized for assessing the predictive value of serum ferritin. 1947 sepsis patients were included. The mortalities of 28-day, 90-day, 180-day and 1-year were 20.18% (n = 393), 28.35% (n = 552), 30.30% (n = 590) and 31.54% (n = 614), respectively. In Model II (adjusted for all potential confounders), for every 1000 ng/ml increment in serum ferritin, the values of OR in mortalities of in 28-day, 90-day, 180-day and 1-year were 1.13 (95% CI 1.07–1.19, P < 0.0001), 1.15 (95% CI 1.09–1.21, P < 0.0001), 1.16 (95% CI 1.10–1.22, P < 0.0001) and 1.17 (95% CI 1.10–1.23, P < 0.0001), respectively. The relationships between serum ferritin level and outcomes were non-linear. The areas under the ROC curve (AUC) of ferritin for predicting mortalities of 28-day, 90-day, 180-day and 1-year were 0.597 (95% CI 0.563–0.629), 0.593 (95% CI 0.564–0.621), 0.595 (95% CI 0.567–0.623) and 0.592 (95% CI 0.564–0.620), respectively. The non-linear relationships between serum ferritin and clinical outcomes in sepsis were found. Serum ferritin had a predictive value for short-term and long-term outcomes in sepsis.

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Section: Discussionmentioning

confidence: 99%

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

Guo

et al. 2023

Sci Rep

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“…Another multicenter cohort study from 13 university hospitals in Korea included 142 patients with SFTS 27 . In addition, a study on SFTS conducted in Nanjing included 256 patients 13 . Notably, our hospital was one of the earliest hospitals to discover this emerging infectious disease 29 and has accumulated a large amount of experience in treating SFTS.…”

Section: Discussionmentioning

confidence: 99%

“…27 In addition, a study on SFTS conducted in Nanjing included 256 patients. 13 Notably, our hospital was one of the earliest hospitals to discover this emerging infectious disease 29 and has accumulated a large amount of experience in treating SFTS. Wuhan Union Hospital is the largest treatment center for SFTS in Central China.…”

Section: Discussionmentioning

confidence: 99%

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High CRP/PNI levels predict an unfavorable prognosis in severe fever with thrombocytopenia syndrome: A propensity score matching study

Guo,

Wang,

Wang

et al. 2024

Immunity Inflam & Disease

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BackgroundThis study aimed to identify a novel inflammatory index and construct a nomogram for predicting in‐hospital mortality due to severe fever with thrombocytopenia syndrome (SFTS).MethodsThis cohort included 610 patients with SFTS hospitalized in Wuhan Union Hospital between March 2017 and November 2022. The ratio of C‐reactive protein (CRP) to the prognostic nutritional index (PNI) was calculated and used to reflect patients' inflammatory status. Propensity score matching (PSM) was utilized to balance confounding factors between the low‐ and high‐CRP/PNI groups. SFTS individuals from Jinyinhu Hospital were used as the validation cohort.ResultsPatients with SFTS and high CRP/PNI were significantly correlated with a higher percentage of severe and critical SFTS types and higher in‐hospital mortality rates than those with low CRP/PNI. CRP/PNI was the potent risk indicator for in‐hospital mortality in individuals with SFTS. The CRP/PNI nomogram showed a good predictive value for in‐hospital mortality in patients with SFTS. After PSM, the predictive performance of CRP/PNI for 28‐day mortality was excellent. Finally, the CRP/PNI could still assess patients with SFTS at different risks based on SFTS data from another medical center.ConclusionThe CPR/PNI ratio exhibited a strong positive correlation with the SFTS disease type and could predict in‐hospital mortality in the early stages of SFTS. The CPR/PNI ratio could substantially help clinicians facilitate the early identification of patients with high‐risk SFTS and the timely initiation of intensive therapy.

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“…In this survey, 53.15% of patients with HFRS had normal white blood cell counts; therefore, white blood cell counts, platelet counts, and urine protein do not directly reflect whether a patient has HFRS, and the accuracy of laboratory indicators for HFRS can be affected by the presence of certain underlying diseases in patients. Studies have shown that the levels of procalcitonin (PCT) and C-reactive protein (CRP) in HFRS patients are significantly increased and are positively associated with the clinical severity of HFRS [ 27 , 28 ]. Therefore, the clinical diagnosis of HFRS combined with PCT and CRP results can improve the accuracy of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Molecular Epidemiology of Hemorrhagic Fever with Renal Syndrome Caused by Orthohantaviruses in Xiangyun County, Dali Prefecture, Yunnan Province, China

Huang,

Fu,

Han

et al. 2023

Vaccines

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Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease transmitted by several rodent species. We obtained clinical data of HFRS patients from the medical records of the People’s Hospital of Xiangyun County in Dali Prefecture from July 2019 to August 2021. We collected epidemiological data of HFRS patients through interviews and investigated host animals using the night clip or night cage method. We systematically performed epidemiological analyses of patients and host animals. The differences in the presence of rodent activity at home (χ2 = 8.75, p = 0.031 < 0.05), of rodent-proof equipment in the food (χ2 = 9.19, p = 0.025 < 0.05), and of rodents or rodent excrement in the workplace (χ2 = 10.35, p = 0.014 < 0.05) were statistically different in the four clinical types, including mild, medium, severe, and critical HFRS-associated diseases. Furthermore, we conducted molecular detection of orthohantavirus in host animals. The total orthohantavirus infection rate of rodents was 2.72% (9/331); the specific infection rate of specific animal species was 6.10% (5/82) for the Apodemus chevrieri, 100% (1/1) for the Rattus nitidus, 3.77% (2/53) for the Rattus norvegicus, and 12.50% (1/8) for the Crocidura dracula. In this study, a total of 21 strains of orthohantavirus were detected in patients and rodents. The 12 orthohantavirus strains from patients showed a closer relationship with Seoul orthohantavirus (SEOOV) L0199, DLR2, and GZRn60 strains; the six orthohantavirus strains from Rattus norvegicus and Apodemus chevrieri were closely related to SEOOV GZRn60 strain. One strain (XYRn163) from Rattus norvegicus and one strain (XYR.nitidus97) from Rattus nitidus were closely related to SEOOV DLR2 strain; the orthohantavirus strain from Crocidura dracula was closely related to the Luxi orthohantavirus (LUXV) LX309 strain. In conclusion, patients with HFRS in Xuangyun County of Dali Prefecture are predominantly affected by SEOOV, with multiple genotypes of orthohantavirus in host animals, and, most importantly, these orthohantavirus strains constantly demonstrated zoonotic risk in humans.

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Evaluation of Serum Ferritin, Procalcitonin, and C-Reactive Protein for the Prediction of Severity and Mortality in Hemorrhagic Fever With Renal Syndrome

Cited by 8 publications

References 35 publications

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database

High CRP/PNI levels predict an unfavorable prognosis in severe fever with thrombocytopenia syndrome: A propensity score matching study

Clinical and Molecular Epidemiology of Hemorrhagic Fever with Renal Syndrome Caused by Orthohantaviruses in Xiangyun County, Dali Prefecture, Yunnan Province, China

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