Evaluation of Serum Ceruloplasmin Levels as a Biomarker for Oxidative Stress in Patients With Diabetic Retinopathy

Abstract

BackgroundElevated serum ceruloplasmin is a biomarker for oxidative stress. Diabetes mellitus (DM) is known to be a state of oxidative stress which causes complications of DM including diabetic retinopathy (DR). The role of ceruloplasmin in DR is still unclear. MethodsNinety patients of DM were included as cases and after evaluation sub-grouped as those with no DR, nonproliferative DR (NPDR) and proliferative DR (PDR). Serum ceruloplasmin levels were tested in all cases as well as in equal numbers of age and sex-matched controls without DM. Statistical analysis was done with p<0.05 taken as significant. ResultsSerum ceruloplasmin was significantly higher among cases as compared to controls (1222.82±306.15 IU/L versus 868.38±198.80 IU/L, p<0.01). There was no statistical difference between serum ceruloplasmin values in No DR, NPDR and PDR. On receiver operator characteristic curve (ROC) analysis for serum ceruloplasmin as a test for discriminating various parameters, it was seen that serum ceruloplasmin was a good test for discriminating DM from no DM (area under receiver operator characteristic {AUROC}=0.814, 95% CI=0.749-0.868, p<0.0001) with a cut point of >1093 IU/L yielding a sensitivity of 63.33% and specificity of 87.78%.

Systemic Anti-Inflammatory Therapy Aided by Curcumin-Laden Double-Headed Nanoparticles Combined with Injectable Long-Acting Insulin in a Rodent Model of Diabetes Eye Disease

“…In RNaseq analysis of the retina, an increased Cp expression (Figure I) was observed, which was improved by nCUR+INS and INS groups, while CUR and nCUR had little to no effect. These observations align well with the literature, where the Cp level was significantly elevated in DR patients . The transcriptomic analysis of the retina further revealed the regulation of cytosolic iron–sulfur cluster biogenesis (Figure J) and nonheme Fe-containing protein pirin (Figure K).…”

“…These observations align well with the literature, where the Cp level was significantly elevated in DR patients. 38 The transcriptomic analysis of the retina further revealed the regulation of cytosolic iron−sulfur cluster biogenesis (Figure 7J) and nonheme Fe-containing protein pirin (Figure 7K). A significantly lower expression of Ciao 1 and pirin was observed in the diabetic group, and all the treatments neutralized this effect in ciao1 but not pirin expression.…”

Effect of Atherosclerosis Developed from Diabetes on Ceruloplasmin Concentration, Ceruloplasmin Ferroxidase Activity and its Specific in Sera of Diabetic Iraqi Patients with Atherosclerosis

“…elevated glycation accompanied with an altered lipid profile in T2DM causes enhanced generation of this enzyme which could be used as possible biomarker for identifying accelerated glycation and atherosclerosis 23 . Another study revealed a highly significant increase in CP concentration in sera of patients with T2DM 24 ; There is metabolic and OS in uncontrolled diabetes 25 , CP is thought to be a scavenger so its levels increase.…”

Post-traumatic Stress Disorder: The Influence of the Environmental Context and Analysis of Oxidative Stress and Inflammatory and Glycemic Markers in Women Living in Kurdistan Regional Government-Iraq

“…In contrast to decreased GSH, there was an elevation in the concentration of non-enzymatic antioxidant CP in PTSD individuals when compared to healthy control groups. Ceruloplasmin has an essential role as a protective agent against oxidative stress and in the control of lipid oxidation [ 46 ]. Therefore, serum CP levels in PTSD individuals are elevated to overcome the elevation in MDA levels in order to protect the body from lipid peroxidation.…”