Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Fartashvand, M; Hajisadeghi, Yaghoub

doi:10.12681/jhvms.15608

Cited by 5 publications

(5 citation statements)

References 21 publications

(27 reference statements)

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“…In horses with colic undergoing emergency abdominal surgery, increases in L-lactate and cTnI were observed, and both were higher in the animals that did not survive surgical treatment [27]. In sheep with acute ruminal acidosis, hyperlactatemia and a significant negative correlation (r = -0.85; P = 0.004) were reported between ruminal pH and serum L-lactate levels, as well as elevation in CK-MB and cTnI [13]. In humans, blood L-lactate has been shown to be a marker of risk stratification and mortality in patients with heart disease [18].…”

Section: Discussionmentioning

confidence: 94%

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Ribeiro

Soares

Coutinho

et al. 2020

Acta Scientiae. Vet.

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Background: Displaced abomasum (DA) is a common and economically important disorder that affects dairy cattle. Nutritional factors and adaptive responses that occur in the peripartum play a central role in the pathogenesis. The measurement of blood metabolites represents a useful tool for monitoring and prognostic determination in affected animals. Therefore, the objective was to evaluate cardiac, energy and hormonal blood markers, lactatemia, and insulin sensitivity in cows diagnosed with right displaced abomasum (RDA) and left displaced abomasum (LDA), comparing them with each other.Materials, Methods & Results: Nineteen cases of abomasum displacement in cows were studied, including 9 cases of RDA and 10 cases of LDA. The diagnosis was established by means of physical examination and measurement of the concentration of chlorides in the ruminal fluid (> 30mEq/L). After diagnosis, clinical-surgical therapeutic management was instituted. At the time of diagnosis (M1) and at the resolution of the case (M2), blood samples were collected to assess the variables: non-esterified fatty acids (NEFA), beta hydroxybutyrate (βHB), L-lactate, creatine kinase (CK), creatine kinase MB (CK-MB), cardiac troponin I (cTnI), lactate dehydrogenase (LDH), glucose, insulin, and cortisol. In addition, insulin sensitivity was estimated using the Revised Quantitative Insulin Sensitivity Check Index (RQUICKI) and RQUICKI-βHB. The means of the variables were compared, separating the effects of groups (RDA and LDA) and moments (M1 and M2), at the level of 5% probability. The concentrations of NEFA, CK-MB, L-lactate, glucose, insulin, and cortisol were higher at M1 and the RQUICKI and RQUICKI-βHB indices were lower at this moment. L-lactate, CK, and CK-MB were higher in the RDA group, while cTnI, βHB, and LDH did not present a group or moment effect. Cardiac markers correlated with the energy profile metabolites, L-lactate, and cortisol.Discussion: The high concentrations of NEFA at M1 reflected the condition of negative energy balance. βHB concentrations were stable, that may be related to the number of days postpartum in which the animals were diagnosed. The hyperglycemic condition and the increase in serum cortisol concentrations found at M1 can be induced by the condition of metabolic stress resulting from the disease. Hyperinsulinemia were recorded in the present study could be an important factor related to the pathogenesis of DA, since there seems to be a correlation between hyperinsulinemia and decreased abomasal emptying rate. The RQUICKI and RQUICKI-βHB indices was significantly lower at M1, which may indicate lower sensitivity of peripheral tissues to insulin at this time. Changes in serum activity of LDH and CK may result from tissue damage due to organ displacement, in addition to damage associated with surgery and the administration of injectable drugs, mainly intramuscularly. The elevation in plasma L-lactate at M1 and in the RDA group may be associated with abomasal hypoperfusion. The high positive correlations found between L-lactate and the variables glucose, insulin, and cortisol reinforcing the association between the concentration of L-lactate and the moment of greatest stress. The increase in cardiac biomarkers may be related to the occurrence of ischemia/reperfusion injury in the abomasum, which involves oxidative stress and the production of inflammatory mediators. The hyperglycemic condition and the higher concentrations of NEFA can also contribute to the occurrence of myocardial injury. The correlations found between cardiac biomarkers and plasma L-lactate, strengthen the idea that there is a relationship between L-lactate and myocardial injury. In this sense, the measurement of blood concentrations of cTnI, CK-MB, and L-lactate could contribute as severity markers and prognosis indicators in cattle with DA.

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Section: Discussionmentioning

confidence: 94%

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Ribeiro

Soares

Coutinho

et al. 2020

Acta Scientiae. Vet.

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“…Although the serum CK-MB activity and serum cTnI concentration were higher in the CG and TG, respectively, these cardiac injury biomarkers remained within the normal range, not varying after induction of the disease, disagreeing with the reports of Fartashvand; Haji-Sadeghi (2017), Kirbas et al (2014b), and Joshi et al (2017) who showed elevation in cTnI and CK-MB in sheep and goats clinically affected by RLA, suggesting some degree of myocardial injury in these animals which presented severe clinical manifestations and a high mortality rate. Possible reasons for the occurrence of cardiac damage in ruminal acidosis include: metabolic acidosis; severe dehydration; oxidative stress, with excessive production of reactive oxygen species; endotoxemia; increased synthesis and release of inflammatory cytokines (CHALMEH et al, 2014;FARTASHVAND;HAJI-SADEGHI, 2017;JOSHI et al, 2017;KATRUKHA, 2013;KIRBAS et al, 2014aKIRBAS et al, , 2014b). Fartashvand; Haji-Sadeghi (2017) indicated a relation between cTnI and the prognosis in ruminal acidosis, finding that animals with more critical ruminal pH values presented the highest concentrations of this biomarker and died acutely.…”

Section: Discussionmentioning

confidence: 99%

“…It is hypothesized that acid-base and electrolyte disturbances and secondary complications associated with RLA cause cardiovascular injury. Recently, cardiac injury biomarkers have been used in studies seeking to evaluate the association between myocardial injury and ruminal acidosis in small ruminants (FARTASHVAND; HAJI-SADEGHI, 2017;JOSHI et al, 2017;KIRBAS et al, 2014a) however, this relationship is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Cardiac biomarkers in goats with experimental ruminal lactic acidosis and supplemented with monensin sodium

Ribeiro¹,

Soares²,

Silva³

et al. 2020

Rev Agr Acad

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Aimed to evaluate creatine kinase MB (CK-MB) and cardiac troponin I (cTnI) in goats with experimental ruminal lactic acidosis (RLA) and supplemented with monensin sodium (MS). Twenty goats were divided into control group (CG) and treatment group (TG) supplemented with 33mg/animal/day of MS. The RLA was induced (10g/Kg body weight of sucrose) and before and post-induction clinical data, ruminal fluid and blood were collected. All animals presented mild RLA, with minimal ruminal pH at 8h post-induction. CK-MB and cTnI were higher in the CG and TG, respectively, without differ between moments. MS at the dose used did not prevent RLA whose severity was not sufficient to cause cardiac injury.

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“…Lungs are characterized by congestion with severe diffuse edema (Lira et al, 2013). Liver failure, muscular weakness, and further rhabdomyolysis are aggravated due to recumbency during ARA (Constable, 2010;Fartashvand and Haji-Sadeghi, 2018).…”

Section: Pathoanatomical Lesionsmentioning

confidence: 99%

Ruminal Acidosis Part I: Clinical manifestations, epidemiology and impact of the disease

Voulgarakis,

Gougoulis,

Psalla

et al. 2023

J Hellenic Vet Med Soc

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Abstract Ruminal acidosis is presented as the most considerable nutritional disorder of ruminants with severe impacts in animal health, animal welfare and considerable economics losses in ovine and bovine herds. The disease can be distinguished as Acute (ARA) and Sub-Acute Ruminal Acidosis (SARA). SARA constitutes as the main nutritional disorder in intensive ruminant farming with several complications, such as liver abscesses, milk fat depression, reduced milk yield and early culling. This paper constitutes the first part of a thorough review about ruminal acidosis. The first part focuses on definition, types of ruminal acidosis, epidemiology, economic impacts and welfare implications.

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Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Cited by 5 publications

References 21 publications

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Cardiac biomarkers in goats with experimental ruminal lactic acidosis and supplemented with monensin sodium

Ruminal Acidosis Part I: Clinical manifestations, epidemiology and impact of the disease

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