Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C

The Effect of Eltrombopag (Promecta) on Thrombocytopenia in Egyptian Patients with Chronic Hepatitis C

“…In our study we found that there was a significant negative correlation between the AST level and the total grams of Eltrombopag needed to reach the target platelet count Esmat et al in 2007 [14] , documented a strong correlation between the AST levels and the degree of fibrosis. This could be explained also by the higher plasma concentration and the longer the half life of Eltrombopag observed in patients with hepatic impairment [15] .…”

Factors associated with advanced liver fibrosis in patients with non-alcoholic liver disease

“…It is important to remember that there is no specific type of collagen or extracellular matrix components in the liver [5]. Hyaluronic acid, as a single biomarker, fulfilled the criteria for a good predictor of fibrosis; it is inexpensive, obtained from blood, and also useful in subjects of different race and indications [41].…”

Prediction of fibrosis in hepatitis C patients: assessment using hydroxyproline and oxidative stress biomarkers

“…Consequently, there is a need for non-invasive methods to accurately diagnose the presence of liver fibrosis and cirrhosis. Most previous studies on non-invasive diagnostics, including breath tests, serum biomarkers and transient elastography (TE), reliably determined the presence or absence of cirrhosis, but did not discriminate between the earlier stages of fibrosis very well [9,15]. Non-invasive reliable biomarkers for diagnosing, grading hepatic fibrosis and monitor outcome of HCV infection treatment are active areas of clinical interest [11,51].…”