Evaluation of serum biomarkers and proteinuria for the early detection of renal damage in dogs with heartworm (Dirofilaria immitis)

Carretón, Elena; Falcón-Cordón, Yaiza; Rodón, Jaume; Matos, Jorge Isidoro; Morchón, Rodrigo; Montoya-Alonso, José Alberto

doi:10.1016/j.vetpar.2020.109144

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…Eosinophilia was a relatively uncommon finding with a frequency of only 20% in those dogs in which it was evaluated, and all 10 dogs with a peripheral eosinophilia were small breed with predominately high estimated worm burden. Proteinuria, which occurs in 19% of dogs with heartworm infection and 50% of dogs with CS, 5,15,40 was identified in the majority of dogs with intracardiac heartworms in this study.…”

Section: Discussionmentioning

confidence: 48%

Intracardiac heartworms in dogs: Clinical and echocardiographic characteristics in 72 cases (2010‐2019)

Romano

Saunders

Gordon

et al. 2020

Veterinary Internal Medicne

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Background: Heartworms, a cause of pulmonary hypertension (PH) in dogs, can migrate from the pulmonary arteries into the heart resulting in life-threatening caval syndrome (CS). Objectives: To describe clinical and echocardiographic characteristics in dogs with intracardiac heartworms including estimated heartworm burden and frequency of PH and pigmenturia. Animals: Seventy-two client-owned dogs with heartworms. Methods: Retrospective study. Data collected from an electronic medical records search for dogs with intracardiac heartworms included clinicopathologic, echocardiographic, and procedural findings. Dogs with heartworms isolated to the pulmonary arteries were excluded. Results: Estimated intracardiac heartworm burden was low in 14 of 72 (19%) and high in 58 of 72 (81%) dogs. The majority were small breed (54/72; 75%; 29/72; 40% Chihuahuas) and had a high likelihood of PH (67/72; 93%). Pigmenturia was the second most common clinical finding (31/72; 43%) after lethargy (32/72; 44%). Anemia (37/55; 36%), pigmenturia (30/58; 52%), and bilirubinuria (28/36; 78%) were significantly more common in dogs with a high worm burden (P < .05). Based on the presence of anemia, pigmenturia, and clinical signs, 18 of 72 dogs (25%) were considered to have CS. Conclusions and Clinical Importance: Although the majority of dogs with intracardiac heartworms had a high worm burden and high likelihood of PH, only 25% had clinical evidence of CS. Echocardiography is a useful tool to identify intracardiac heartworms, detect likelihood of PH, and could be useful for staging heartworm positive small breed dogs for intracardiac heartworm migration.

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Section: Discussionmentioning

confidence: 48%

Intracardiac heartworms in dogs: Clinical and echocardiographic characteristics in 72 cases (2010‐2019)

Romano

Saunders

Gordon

et al. 2020

Veterinary Internal Medicne

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“…As alterações histológicas verificadas no fígado convergem com os achados de Mircean et al (2017) e são evidências que a dirofilariose é uma parasitose que pode provocar modificação da estrutura do parênquima hepático em resposta às toxinas liberadas pelos parasitos na circulação, assim como pela congestão passiva crônica devido à insuficiência cardíaca congestiva direita, o qual resulta em congestão centrolobular, degeneração e necrose dos hepatócitos (McGAVIN et al, 2007;PASCA et al, 2012). et al, , CARRETÓN et al, 2020.…”

Section: Resultsunclassified

Síndrome Cólica Em Equinos: Revisão De Literatura

Mendes¹,

Tavares²,

Carneiro³

et al. 2021

Atualidades Na Saúde E Bem-Estar Animal, Volume 2

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Esta obra está licenciada com uma Licença Creative Commons Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo desta obra e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…Häufig haben Hunde mit Dirofilariose eine Proteinurie. Bei Hunden mit zirkulierenden Mikrofilarien ist die Proteinurie stärker ausgeprägt 55 , 56 . So wurde gezeigt, dass eine experimentelle Infektion mit Dirofilaria immitis zu glomerulären Veränderungen an den Nieren führen kann 57 .…”

Section: Mit Nierenerkrankungen Assoziierte Infektionskrankheitenunclassified

“…≥ 18 μg/dl). Das UPC-Verhältnis war bei Hunden mit hoher Parasitenbelastung und bei Hunden mit Mikrofilariämie signifikant erhöht (p < 0,05) 56 . In einer anderen neueren Studie wurde bei Hunden nach experimenteller Dirofilaria-immitis -Infektion vor allem eine verdickte Basalmembran mit Ablagerungen und zerstörten Fußfortsätzen der Podozyten gefunden.…”

Section: Mit Nierenerkrankungen Assoziierte Infektionskrankheitenunclassified

Rolle systemischer Infektionen bei Nierenerkrankungen des Hundes

Preyß-Jägeler

Hartmann

Dorsch

2022

Tierarztl Prax Ausg K Kleintiere Heimtiere

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ZusammenfassungNierenerkrankungen sind häufige Erkrankungen und Todesursachen beim Hund. Insbesondere für Glomerulopathien und akute Nierenschädigungen können Infektionserreger ursächlich verantwortlich sein. Zu den Infektionen, die in Mittel- und Südeuropa häufig mit der Entstehung von Immunkomplex-Glomerulonephritiden assoziiert und in Deutschland als Reisekrankheiten von Bedeutung sind, gehören Leishmaniose, Dirofilariose und Ehrlichiose. Selten verursachen in Deutschland Anaplasmose, Hepatozoonose, Borreliose und eine durch kleine Babesien versursachte Babesiose Immunkomplex-Glomerulonephritiden. Leptospirose, canine infektiöse Hepatitis und eine durch große Babesien verursachte Babesiose können für akute Nierenschädigungen durch tubulointerstitielle Nephritiden verantwortlich sein. Eine weiterführende Diagnostik zur Identifikation potenziell auslösender Infektionen bei Nierenerkrankungen des Hundes ist daher wichtig für die Prognose und Therapie der Patienten.

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Evaluation of serum biomarkers and proteinuria for the early detection of renal damage in dogs with heartworm (Dirofilaria immitis)

Cited by 10 publications

References 39 publications

Intracardiac heartworms in dogs: Clinical and echocardiographic characteristics in 72 cases (2010‐2019)

Intracardiac heartworms in dogs: Clinical and echocardiographic characteristics in 72 cases (2010‐2019)

Síndrome Cólica Em Equinos: Revisão De Literatura

Rolle systemischer Infektionen bei Nierenerkrankungen des Hundes

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