Evaluation of serum and salivary total sialic acid and α-l-fucosidase in patients with oral precancerous conditions and oral cancer

Vajaria, Bhairavi N.; Patel, Kinjal D.; Begum, Rasheedunnisa; Shah, Franky D.; Patel, J. D.; Shukla, Shilin N.; Patel, Prabhudas S.

doi:10.1016/j.oooo.2013.01.004

Cited by 36 publications

(24 citation statements)

References 35 publications

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“…Different researchers have reported increased serum (11 - 15) and salivary (10, 12, 14-16) sialic acid levels in oral cancer patients. Sialic acids are sugar compounds at the end of oligosaccharide chains of glycoproteins and glycolipids, which play an important role in the development of neoplastic behaviors, as important compounds of cell membranes (17).…”

Section: Introductionmentioning

confidence: 97%

Salivary Sialic Acid Levels in Smokeless Tobacco Users

Mollashahi

Honarmand

Nakhaee

et al. 2016

Int J High Risk Behav Addict

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BackgroundSmokeless tobacco chewing is one of the known risk factors for oral cancer. It is consumed widely by residents of southeastern Iran.ObjectivesIn this study, salivary free and total sialic acid, and total protein were compared in paan consumers and non-consumers.Patients and MethodsIn this cross-sectional study, unstimulated saliva of 94 subjects (44 paan consumers and 50 non-consumers) who were referred to the oral medicine department of the dentistry school of Zahedan were collected. Salivary free and total sialic acid, and total protein concentration were measured by standard biochemical methods, and the obtained data were analyzed using SPSS 20 through the non-parametric Mann-Whitney test.ResultsThe concentration of salivary free sialic acid (23.21 ± 18.98 mg/L) was significantly increased in paan consumers. The concentration of salivary Total sialic acid (TSA) (39.57 ± 26.58 mg/L) and total protein (0.77 ± 0.81 mg/mL) showed increases in paan consumers, however, the results were not statistically significant.ConclusionsSalivary free and total sialic acid, and total protein were higher in the paan consumers compared to non-consumers. Due to the carcinogenic effect of smokeless tobacco, measurement of these parameters in saliva may be useful in early detection of oral cancer.

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Section: Introductionmentioning

confidence: 97%

Salivary Sialic Acid Levels in Smokeless Tobacco Users

Mollashahi

Honarmand

Nakhaee

et al. 2016

Int J High Risk Behav Addict

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“…Variability in the levels of potential OSCC salivary biomarkers in both non-cancerous individuals and OSCC patients, suggest unknown confounding factors. Without standardization and validation of biomarkers, valuable research resources are being squandered, and the experts in this research ield is needed to discuss this issue and ind a way to establish the standards needed [67]. Salivary biomarkers represent a promising non-invasive approach for oral cancer detection, and an area of strong research interest.…”

Section: Salivary Biomarkersmentioning

confidence: 99%

“…However, some issues (These issues include a lack of standardization for saliva sample collection, processing and storage.) need to be resolved in order to establish this approach as a reliable, highly sensitive and speci ic method for clinical use [67].…”

Section: Salivary Biomarkersmentioning

confidence: 99%

Promising Future in the Detection of Oral Cancer by Using Advance Screening Technology

MY¹

2016

J Oral Health Craniofac Sci

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“…The salivary TSA/TP and alpha-L-fucosidase activity were significantly increased in patients with precancerous conditions and cancer compared to the controls (p=0.005 and p=0.001, respectively) [62]. …”

Section: Current State Of Ossc-specific Salivary Biomarkersmentioning

confidence: 99%

Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

Yakob

Fuentes

Wang

et al. 2014

Curr Oral Health Rep

118

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Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on thorough clinical oral examination combined with biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional “omics”, including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC.

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Evaluation of serum and salivary total sialic acid and α-l-fucosidase in patients with oral precancerous conditions and oral cancer

Cited by 36 publications

References 35 publications

Salivary Sialic Acid Levels in Smokeless Tobacco Users

Salivary Sialic Acid Levels in Smokeless Tobacco Users

Promising Future in the Detection of Oral Cancer by Using Advance Screening Technology

Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

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