Evaluation of serum aminoterminal propeptide of type III procollagen as an early marker of the active fibrotic process in asbestos-exposed workers.

Cavalleri, A.; Gobba, Fabriziomaria; Bacchella, L.; Ferrari, Davide

doi:10.5271/sjweh.1723

Cited by 7 publications

(9 citation statements)

References 14 publications

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“…Secondly, no measures of serum levels of markers of matrix turnover have been done in the present study. However, serum pro-collagen type III amino-terminal peptide is either an early indicator of early lung fibrosis, 48 is associated with poor HF conditions and increase of early death risks, 8,49 and its value reduces in HF patients treated with spironolactone. 8 Therefore the relationship between DLCO improvement and lung connective tissue changes in spironalactone-treated HF patients is attractive but remains speculative.…”

Section: Study Limitationsmentioning

confidence: 99%

Spironolactone improves lung diffusion in chronic heart failure

Agostoni

Magini

Andreini

et al. 2004

European Heart Journal

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Section: Study Limitationsmentioning

confidence: 99%

Spironolactone improves lung diffusion in chronic heart failure

Agostoni

Magini

Andreini

et al. 2004

European Heart Journal

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“…(1) a switch of fibroblasts that initially synthesize collagen III and later switch to collagen I production, (2) proliferation of subsets of fibroblasts with distinct production of type I and III collagens, or (3) increased degradation rate of collagen IN compared to type I collagen [Raghu and Kinsella, 1993]. N-terminal type III procollagen peptides (PIIIP) have been measured in bronchoalveolar lavage or serum of subjects with fibrotic lung disease including idiopatic pulmonary fibrosis [Low et al, 1983;Cantin et al, 1988] and asbestosis [Okazaki et al, 1983;Cavalleri et al, 1991]. Previously, serum PIIIP was found to be related to radiological stage of CWP [Janssen et al, 1992a].…”

Section: Co/zagens In F/je /Wngmentioning

confidence: 99%

“…In the search for biological markers to better predict or estimate development, outcome, or activity of disease, determination of the serum levels of the procollagen type III peptide (PIIIP) -a degradation product of the type III procollagen precursor-has been widely applied in the context of many diseases of the lung. Several studies have established relations between PIIIP levels in serum or bronchoalveolar lavage (BAL) and several lung diseases [Low et al, 1992;Cavalleri et al, 1991;Pohl et al, 1992;Bjermer et al, 1986]; Other studies have failed to show clear data on the role of PIIIP in pulmonary diseases [Okazaki et al,1987;Low et al, 1983;Luisetti et al, 1990] Serum procoZ/agen type 7// pepffVfe m coal sorters' pneumocomosis: a/ice year /o//ou;-up study be highly dependent on the type of lung disease [Okzakai et al, 1987;Low et al, 1983;Cantin et al, 1988]. Interestingly however, within a single disease a large variation in PIIIP levels often is also present at the individual level, such as in asbestosis [Cavalleri et al, 1991;Okazaki et al, 1987], interstitial pulmonary fibrosis [Low et al, 1983;Luisetti et al, 1990], sarcoidosis [Pohl et al, 1992;Bjermer et al, 1986;Low et al, 1983;Cantin et al, 1988], farmers lung [Antinnen et al, 19861], or, for instance, in rheumatoid lung disease [Gilligan et al, 1990].…”

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confidence: 99%

“…Several studies have established relations between PIIIP levels in serum or bronchoalveolar lavage (BAL) and several lung diseases [Low et al, 1992;Cavalleri et al, 1991;Pohl et al, 1992;Bjermer et al, 1986]; Other studies have failed to show clear data on the role of PIIIP in pulmonary diseases [Okazaki et al,1987;Low et al, 1983;Luisetti et al, 1990] Serum procoZ/agen type 7// pepffVfe m coal sorters' pneumocomosis: a/ice year /o//ou;-up study be highly dependent on the type of lung disease [Okzakai et al, 1987;Low et al, 1983;Cantin et al, 1988]. Interestingly however, within a single disease a large variation in PIIIP levels often is also present at the individual level, such as in asbestosis [Cavalleri et al, 1991;Okazaki et al, 1987], interstitial pulmonary fibrosis [Low et al, 1983;Luisetti et al, 1990], sarcoidosis [Pohl et al, 1992;Bjermer et al, 1986;Low et al, 1983;Cantin et al, 1988], farmers lung [Antinnen et al, 19861], or, for instance, in rheumatoid lung disease [Gilligan et al, 1990]. In several studies it has been suggested that serum PIIIP measurements can contribute to early diagnosis [Low et al, 1992;Cavalleri et al, 1991;Okazaki et al,1987;Okazaki et al, 1983].…”

mentioning

confidence: 99%

“…Interestingly however, within a single disease a large variation in PIIIP levels often is also present at the individual level, such as in asbestosis [Cavalleri et al, 1991;Okazaki et al, 1987], interstitial pulmonary fibrosis [Low et al, 1983;Luisetti et al, 1990], sarcoidosis [Pohl et al, 1992;Bjermer et al, 1986;Low et al, 1983;Cantin et al, 1988], farmers lung [Antinnen et al, 19861], or, for instance, in rheumatoid lung disease [Gilligan et al, 1990]. In several studies it has been suggested that serum PIIIP measurements can contribute to early diagnosis [Low et al, 1992;Cavalleri et al, 1991;Okazaki et al,1987;Okazaki et al, 1983]. The only way to determine the role of (serum) PIIIP measurements in predicting the development or progression of a disease is through a longitudinal design.…”

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confidence: 99%

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Biomarkers of mineral dust induced lung disorders : molecular epidemiologic studies in coal workers

Schins¹

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Evaluation of serum type III procollagen peptide as an exposure marker in retired coal workers

Schins

Lamers

Préat³

et al. 1995

Int. Arch Occup Environ Heath

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Serum type III procollagen peptide (PIIIP), a degradation product of the type III collagen precursor, has been put forward as an exposure marker for mineral dust. We evaluated PIIIP levels as a marker of exposure to and effects of coal dust in retired coal miners (n = 104). To this end: (a) the individual cumulative dust exposure was calculated from job-exposure matrices, and (b) in addition to routine chest radiography (CR) of all miners according to the criteria of the International Labour Organisation (ILO), a subgroup (n = 46) was screened by high-resolution computed tomography (HRCT). Profusion score (CR and HRCT) tended to increase with cumulative dust exposure, even in the absence of CR evidence for pneumoconiosis (i.e. CR < or = 0/1, n = 35). In contrast to our previous findings in active miners, PIIIP levels were not increased in miners as compared with non-dust-exposed controls (n = 29), and no differences were observed between miners without (ILO = 0/0) and miners with coal workers' pneumoconiosis (CWP; ILO > or = 0/1). No trend in PIIIP versus pneumoconiosis stage was present, either by CR or by the more sensitive HRCT score. PIIIP was also unrelated to any lung function parameter (FEV1, FVC, impedance, diffusion capacity). Age, medication, medical history and smoking habits had no significant effect on PIIIP levels. In the miners with CWP (i.e. ILO > 0/0, n = 28) a significant negative correlation was present between PIIIP values and (log) cumulative dust exposure. This decrease in serum PIIIP levels with increasing cumulative exposure may be due to chronic adaptive changes in type III collagen deposition and/or breakdown. Other relations between exposure and PIIIP were not observed. In conclusion, the present findings do not support the use of serum type III procollagen peptide as a marker of exposure to and (early) interstitial or respiratory effects of coal dust.

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Evaluation of serum aminoterminal propeptide of type III procollagen as an early marker of the active fibrotic process in asbestos-exposed workers.

Cited by 7 publications

References 14 publications

Spironolactone improves lung diffusion in chronic heart failure

Spironolactone improves lung diffusion in chronic heart failure

Biomarkers of mineral dust induced lung disorders : molecular epidemiologic studies in coal workers

Evaluation of serum type III procollagen peptide as an exposure marker in retired coal workers

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