Evaluation of Serum 1,5-Anhydroglucitol Levels as Hyperglycemic Indicator in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Abstract

Background and Objectives: 1,5-Anhydroglucitol (1,5-AG) is an emerging marker in the acute assessment of glycemia. 1,5-AG has been shown to be associated with glycemic excursions and also been found to have association with microvascular complications of diabetes and atherosclerosis. This study aimed to evaluate serum 1,5-AG concentration in newly diagnosed type 2 diabetes patients and find the correlation between serum 1,5-AG concentration and blood glucose concentration. Materials and Methods: The study group consisted of 60 type 2 diabetes patients aged 35–55 years and 60 age- and sex-matched controls. 1,5-AG plasma level, HbA1c, fructosamine, and blood glucose were measured in all subjects. Data analysis was done using SPSS software. Results and Discussion: 1,5-AG levels were significantly lower in patients with diabetes mellitus when compared with the control group. 1,5-AG serum level negatively correlated with postprandial blood glucose. The linear regression analysis revealed that 1,5-AG had a linear association with postprandial blood glucose. Conclusion: Serum 1,5-AG levels significantly decreased with an increase in plasma glucose concentrations in patients with diabetes mellitus. Thus monitoring of serum 1,5-AG level may be useful for evaluating glycemic control in patients with newly diagnosed diabetes mellitus.