Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms

Gannon, Robert L.; Millan, Mark J.

doi:10.1007/s00213-007-0903-z

Cited by 39 publications

(29 citation statements)

References 76 publications

(92 reference statements)

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“…This is consistent with data from acute increases in 5-HT neuronal activity, which have been shown to attenuate photic phase shifts (Challet et al, 2001;Gannon and Millan, 2007;Mistlberger et al, 2002). There is strong evidence for a number of 5-HT receptors in the SCN, namely 5-HT1A, 5-HT1B, 5-HT2C and 5-HT7 (Lovenberg et al, 1993;Roca et al, 1993).…”

Section: Discussionsupporting

confidence: 72%

“…It is well-known that serotonergic agonists can phase shift the circadian clock in the SCN in vitro and in vivo (Challet et al, 1998;Edgar et al, 1993). Furthermore, acute pharmacological increases in 5-HT have been shown to attenuate the responsivity of animals to photic phase shifts (Challet et al, 2001;Gannon and Millan, 2007) and destruction of serotonergic fibers increases the magnitude of photic phase shifts (Bradbury et al, 1997). Serotonergic effects on photic phase shifting may relate to the believed role of 5-HT in inhibiting the release of glutamate from retinal terminals and decreasing the responsiveness of retinorecipient cells in the SCN (Rea and Pickard, 2000;Ying and Rusak, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Circadian rhythmicity in serotonin transporter knockout mice

2012

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Circadian rhythmicity in serotonin transporter knockout mice

2012

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“…As previously (Gannon and Millan, 2007), Syrian hamsters were maintained in a 14 : 10 h light : dark schedule for several weeks before being transferred to conditions of constant darkness (DD) where they had access to small running wheels of 19 cm in diameter. Wheel running was recorded in 10 min bins using Actimetrics ClockLab hardware (Evanstown, IL, USA).…”

Section: Light-induced Phase-advances In Circadian Wheel Running Rhytmentioning

confidence: 99%

“…Light-induced phase shifts of activity rhythms in hamsters are blunted by several classes of antidepressant, including SSRIs (Millan, 2006;Gannon and Millan 2007). They likely act in the suprachiasmatic nucleus, which contains a high density of 5-HT transporters on serotonergic terminals originating in the median raphe nucleus (Legutko and Gannon, 2001).…”

Section: Additive Influence On Circadian Rhythmsmentioning

confidence: 99%

Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization

Gobert

Brocco

Dekeyne

et al. 2008

Neuropsychopharmacol

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Though neurokinin 1 (NK 1 ) receptor antagonists are active in experimental models of depression, clinical efficacy has proven disappointing. This encourages interest in association of NK 1 receptor blockade with inhibition of serotonin (5-HT) reuptake. The selective NK 1 antagonist, GR205171, dose-dependently enhanced citalopram-induced elevations of extracellular levels of 5-HT in frontal cortex, an action expressed stereospecifically vs its less active distomer, GR226206. Further, increases in 5-HT levels in dorsal hippocampus, basolateral amygdala, nucleus accumbens, and striatum were likewise potentiated, and GR205171 similarly facilitated the influence of fluoxetine upon levels of 5-HT, as well as dopamine and noradrenaline. In parallel electrophysiological studies, the inhibitory influence of citalopram and fluoxetine upon raphe-localized serotonergic neurones was stereospecifically blunted by GR205171. Antidepressant actions of citalopram in a forced-swim test in mice were stereospecifically potentiated by GR205171, and it also enhanced attenuation by citalopram of stress-related ultrasonic vocalizations in rats. Further, GR205171 and citalopram additively abrogated the advance in circadian rhythms provoked by exposure to light in hamsters. By contrast, GR205171 stereospecifically blocked anxiogenic actions of citalopram in social interaction procedures in rats and gerbils, and stereospecifically abolished facilitation of fearinduced foot tapping by fluoxetine in gerbils. By analogy to GR205171, a further NK 1 antagonist, RP67580, enhanced the influence of citalopram upon frontocortical levels of 5-HT and potentiated its actions in the forced swim test. In conclusion, NK 1 receptor blockade differentially modulates functional actions of SSRIs: antidepressant properties are reinforced, whereas anxiogenic effects are attenuated. Combined NK 1 receptor antagonism/5-HT reuptake inhibition may offer advantages in the management of depressed and anxious states.

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“…Incidentally, some therapeutic treatments, such as some antidepressants, total sleep deprivation, and bright light therapy have been shown to affect circadian rhythm generation. One of the most popular antidepressant, selective serotonin reuptake inhibitors (SSRIs) have been reported to affect circadian phase in vivo and in vitro (Gannon and Millan, 2007;Prosser et al, 2006;Sprouse et al, 2006). However, no data are available that describe the effects of these agents on circadian parameters (period, amplitude and damping rate) in dissociated cellular oscillator organizations in periphery.…”

Section: Introductionmentioning

confidence: 99%

Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts

et al. 2008

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Alterations in circadian rhythm generation may be related to the development of mood disorders. Although it has been reported that the most popular antidepressant, selective serotonin reuptake inhibitors (SSRIs) affect circadian phase, no data are available that describe the effects of SSRIs on other circadian parameters (period, amplitude and damping rate) in dissociated cells. In the present study we used real-time monitoring of bioluminescence in rat-1 fibroblasts expressing the Period1-luciferase transgene, and that in Period1-luciferase transgenic mouse suprachiasmatic nucleus (SCN) explants, in order to characterize the effects of SSRI on circadian oscillator function in vitro. We found that mRNA of the serotonin transporter (SERT), a target of SSRIs, was expressed in rat-1 fibroblasts. Sertraline, fluoxetine, fluvoxamine, citalopram and paroxetine all significantly shortened the period of Period1-bioluminescence rhythms in rat-1 fibroblasts. The amplitude was reduced by sertraline, and the damping rate was decreased by sertraline, fluoxetine, flvoxamine and paroxetine. The effect of sertraline was dose-dependent, and it also shortened the circadian period in the SCN. SERT is associated with lipid microdomains, which are required for efficient SERT activity. Indeed, cholesterol chelating reagent methyl-β-cyclodextrin significantly reduced the period and the amplitude in rat-1 fibroblasts. Furthermore, lipid binding reagent xylazine significantly reduced the period. In summary our data present evidence that SSRIs affect circadian rhythmicity. The action of SSRIs is likely mediated by suppression of SERT activity. A better understanding of the relationship between mental illness and biological timing may yield new insight into disease etiology and avenues for treatment.

show abstract

Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms

Cited by 39 publications

References 76 publications

Circadian rhythmicity in serotonin transporter knockout mice

Circadian rhythmicity in serotonin transporter knockout mice

Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization

Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts

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