Evaluation of sequential effect of isotretinoin on the haematological parameters in patients with acne vulgaris

Gençoğlan, Gülsüm; İnanır, Işıl; Miskioğlu, Mine; Gündüz, Kamer

doi:10.1080/15569527.2017.1359837

Cited by 18 publications

(22 citation statements)

References 18 publications

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“…Similar to the findings of Gencoglan et al [17], our patient also had thrombocytosis after one month of treatment with isotretinoin. Yet, unlike their findings, the platelet count only returned to baseline after one month of therapy discontinuation, rather than after completing the course of treatment as reported by Gencoglan et al [17].…”

Section: Discussionsupporting

confidence: 92%

Isotretinoin-Induced Thrombocytosis in a Patient With Acne Vulgaris: A Case Report

Al-Yasi¹,

Hawsawi²,

Malebari³

et al. 2021

Cureus

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Isotretinoin is one of the first-line medications for the treatment of acne. One of the reported side effects of isotretinoin is thrombocytopenia, in addition to other abnormalities such as incomplete blood count. However, reports on thrombocytosis associated with isotretinoin are controversial. The present report discusses the case of a patient with acne vulgaris who was treated with isotretinoin and consequently suffered from isotretinoin-induced thrombocytosis.A 20-year-old female patient was diagnosed with acne vulgaris and started treatment with systemic isotretinoin (20 mg once daily) for one month. A baseline complete blood count was performed, as well as another blood count after one month of medication administration. Platelet count was recorded at each visit. The baseline platelet count was within the normal range; however, it was found to be elevated after one month of treatment. Accordingly, the medication was discontinued, and the platelet count returned to normal levels after one month, as measured during the monthly visit. The patient also experienced seizure episodes during treatment, which did not cease with the treatment discontinuation. Although isotretinoininduced thrombocytosis is considered a rare side-effect for isotretinoin, it should be routinely monitored in high-risk patients and those undergoing surgeries. Further prospective studies on isotretinoin-induced thrombocytosis need to be conducted to gain a deeper insight into the various aspects related to the condition.

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Section: Discussionsupporting

confidence: 92%

Isotretinoin-Induced Thrombocytosis in a Patient With Acne Vulgaris: A Case Report

Al-Yasi¹,

Hawsawi²,

Malebari³

et al. 2021

Cureus

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“…The mean age of the patients was 23.03 ± 4.35 years. The median (minimum-maximum) age of the patients was 22 (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Resultsmentioning

confidence: 99%

“…Platelet count increased in the 1st month of the treatment and then it decreased. MCV increased at the end of the treatment (27). Seckin et al investigated the effect of isotretinoin on inflammatory markers and hematological parameters.…”

Section: Lee Et Al Reviewed the Laboratory Changes In Patients With mentioning

confidence: 99%

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Tamer

Yüksel

Avcı³

2019

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin. Methods: The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study. Results: Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment. Conclusions: The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.

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“…We did not find any studies which used CBC parameters or MHR ratio between acne patients and HCs. In a few recent studies, CBC parameters have been considered as pre‐treatment and post‐treatment inflammation marker in acne patients using isotretinoin 23‐26 . In one study, pre‐treatment and post‐treatment MHR ratios of patients using isotretinoin were examined and it was reported that isotretinoin treatment increases MHR.…”

Section: Discussionmentioning

confidence: 99%

“…In a few recent studies, CBC parameters have been considered as pre-treatment and post-treatment inflammation marker in acne patients using isotretinoin. [23][24][25][26] In one study, pre-treatment and post-treatment MHR ratios of patients using isotretinoin were examined and it was reported that isotretinoin treatment increases MHR. It has been reported that although other inflammatory parameters decreased with isotretinoin treatment, there was an increase in MHR ratio and that this increase could be an indicator of inflammation-induced atherosclerosis risk.…”

Section: Ta B L E 1 Distribution Of Patient and Control Groups By Gendermentioning

confidence: 99%

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

2020

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Acne vulgaris is a common inflammatory skin disease that affects the pilosebaceous unit. 1 Acne vulgaris affects 9.4% of the world population. It is most common among young people. It is more common among men; however, its prevalence increases with age in women. In male patients, the probability of severe acne is higher when compared with female patients. 2 Increased sebum production, hyperkeratosis in follicular infundibulum, inflammation and Propionibacterium acne (P acne) are among aetiological factors. Acne vulgaris lesions are first seen on the face and thus can affect patients' quality of life negatively. It has been claimed that acne can cause psychological diseases such as anxiety, low self-worth and depression among adolescents and adults. 1 Although its definite pathogenesis is not clear, immune response and inflammatory lesions caused by the P acne infection are considered as important factors. 3,4 Complete blood count is an analytical test with low cost and it is performed with automatic counting devices and it is used routinely. Complete blood count (CBC) parameters are used as diagnosis biomarkers for many diseases related with inflammatory processes.

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Evaluation of sequential effect of isotretinoin on the haematological parameters in patients with acne vulgaris

Abstract: Although some changes occur in haematological parameters during isotretinoin therapy, all of these changes remain within the normal range. Evaluating the spot values at any time during treatment may cause misinterpretations.

Cited by 18 publications

References 18 publications

Isotretinoin-Induced Thrombocytosis in a Patient With Acne Vulgaris: A Case Report

Isotretinoin-Induced Thrombocytosis in a Patient With Acne Vulgaris: A Case Report

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

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