Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Iacuzzo, Cristiana; Troian, Marina; Bonadio, Laura; Bonazza, Deborah; Dobrinja, Chiara; Scomersi, Serena; Giudici, Fabiola; Zanconati, Fabrizio; Bortul, Marina

doi:10.4172/2155-9929.1000359

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…In contrast to our results, Motomura et al reported that TIC was better than FSA 21 . Lacuzzo et al also demonstrated similar results and reported that TIC was a reliable and fast technique for identifying intraoperative SLN metastasis 22 . They showed that TIC had lower sensitivity but much greater specificity, which is not in agreement with our findings 22 .…”

Section: Discussioncontrasting

confidence: 99%

“…Lacuzzo et al also demonstrated similar results and reported that TIC was a reliable and fast technique for identifying intraoperative SLN metastasis 22 . They showed that TIC had lower sensitivity but much greater specificity, which is not in agreement with our findings 22 . Russo et al demonstrated that FSA had an acceptable false‐negative rate during SLN biopsy 23 .…”

Section: Discussionmentioning

confidence: 41%

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Comparing scraping cytology with touch imprint cytology and frozen section analysis in the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer

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Hosseinzadeh

Farahi

et al. 2021

Diagnostic Cytopathology

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Background Breast cancer is a common cancer in the female population. Sentinel lymph node (SLN) in breast cancer patients can be evaluated by different methods including intraoperative frozen section analysis (FSA), touch imprint cytology (TIC), and scraping cytology (SC). In this study, in addition to investigating TIC and FSA, we focused on SC to evaluate the diagnostic value of this almost new method. Materials and methods In this retrospective study, the quadrantectomy and sentinel lymph node resection of 150 specimens with mammography and core needle biopsy‐confirmed breast cancer were examined. Of the 150 participants, 77 and 73 had negative and positive results for the permanent pathology of SLN metastasis, respectively. Intra‐operative FSA, TIC, and SC for SLN were performed for the patients and all were confirmed by permanent pathology. Results All the specimens were taken from females aged between 25 and 82 years. The sensitivity and specificity of TIC, FS, and SC were 73% and 50%, 92.6% and 50%, and 92.1% and 50%, respectively. Among the three techniques, TIC had the lowest positive and negative predictive values. However, FS had the highest positive predictive value whereas SC had the highest negative predictive value. Conclusion In addition to FS and TIC as rapid, cost‐effective, and reliable diagnostic methods in SLN metastasis, SC is an acceptable and highly sensitive method. A combination of these methods may provide a more favorable diagnostic value for SLN assessment in breast cancer patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 41%

Comparing scraping cytology with touch imprint cytology and frozen section analysis in the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer

Avval

Hosseinzadeh

Farahi

et al. 2021

Diagnostic Cytopathology

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“…It has been widely used in cervical and anal cancer screening programs, which have achieved a great reduction in its incidence in many countries [ 25 , 26 ]. This simple morphology-based diagnostic method is routinely used in clinical practice for the diagnosis, decision-making, and treatment of benign and malignant conditions, either alone or complementary to standard surgical pathology diagnosis [ 27 , 28 , 29 ]. Diagnostic cytology has many advantages, such as being a simpler and less-invasive procedure than biopsy or surgical resection.…”

Section: Introductionmentioning

confidence: 99%

Cytology Smears: An Enhanced Alternative Method for Colorectal Cancer pN Stage—A Multicentre Study

Diaz‐Mercedes

Archilla

Lahoz

et al. 2022

Cancers

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Stage II colorectal cancer (CRC) recurrence remains a clinical problem. Some of these patients are true stage III CRC with a pN0 pathology stage. This large prospective multicentre cohort study aimed at evaluating the diagnostic ability of lymph node (LN) cytology smears to perform the pN stage and compare it with the conventional haematoxylin and eosin (H&E) pathology pN stage. Additionally, we used the One-Step Nucleic Acid Amplification (OSNA), a high-sensitive molecular method of LN staging. A total of 3,936 fresh LNs from 217 CRC surgical specimens were examined by three methods, H&E, LN cytology smears, and OSNA. H&E detected 29% of patients with positive LNs, cytology smears 35%, and OSNA 33.2% (p < 0.0001). H&E and cytology concordantly classified 92.2% of tumours, and 88.5% between OSNA and H&E. Cytology had 96.8% sensitivity and 90.3% specificity to discriminate positive/negative patients compared to H&E (p = 0.004), and 87.3% sensitivity and 89% specificity when compared to OSNA (p = 0.56). Patients with positive LNs detected by any of the three methods had significantly worse disease-free and overall survival. We conclude that pN stage accuracy for detecting positive LNs is superior with LN cytological smears than with conventional H&E, which would enable a better pN stage and management of early-stage CRC patients.

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Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Cited by 2 publications

References 25 publications

Comparing scraping cytology with touch imprint cytology and frozen section analysis in the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer

Comparing scraping cytology with touch imprint cytology and frozen section analysis in the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer

Cytology Smears: An Enhanced Alternative Method for Colorectal Cancer pN Stage—A Multicentre Study

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