Evaluation of sensory recovery after reconstruction of digital nerves of the hand using muscle-in-vein conduits in comparison to nerve suture or nerve autografting

Manoli, Theodora; Schulz, Lukas; Stahl, Stéphane; Jaminet, Patrick; Schaller, Hans-Eberhard

doi:10.1002/micr.22302

Cited by 49 publications

(62 citation statements)

References 30 publications

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“…Some earlier experimental (Brunelli et al., 1993) and recent clinical work (Manoli, Schulz, et al., 2014) did, however, not report any inferiority of MVGs in comparison to ANGs especially when shorter nerve defects have been bridged. Despite the fact, however, that MVGs also resulted in considerable recovery of fine and gross motor skills in our study, the multimodal analysis of functional recovery performed was comprehensive and therefore eventually more sensitive to otherwise undetectable variations between the graft types.…”

Section: Discussionmentioning

confidence: 89%

“…Usage of ANGs, however, leads to considerable donor side morbidity. Therefore, autologous muscle‐in‐vein grafts (MVGs), leading only to minor donor side morbidity (Manoli, Schulz, Stahl, Jaminet, & Schaller, 2014), represent promising alternative digital nerve grafts (Manoli, Schulz, et al., 2014; Marcoccio & Vigasio, 2010; Tos, Battiston, Ciclamini, Geuna, & Artiaco, 2012) as do several clinically approved biodegradable nerve guidance conduits (NGCs) (Bertleff, Meek, & Nicolai, 2005; Donoghoe, Rosson, & Dellon, 2007; Lohmeyer, Siemers, Machens, & Mailander, 2009; Meyer et al., 2016). …”

Section: Introductionmentioning

confidence: 99%

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Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

2017

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IntroductionThe rat median nerve injury and repair model gets increasingly important for research on novel bioartificial nerve grafts. It allows follow‐up evaluation of the recovery of the forepaw functional ability with several sensitive techniques. The reflex‐based grasping test, the skilled forelimb reaching staircase test, as well as electrodiagnostic recordings have been described useful in this context. Currently, no standard values exist, however, for comparison or comprehensive correlation of results obtained in each of the three methods after nerve gap repair in adult rats.MethodsHere, we bilaterally reconstructed 7‐mm median nerve gaps with autologous nerve grafts (ANG) or autologous muscle‐in‐vein grafts (MVG), respectively. During 8 and 12 weeks of observation, functional recovery of each paw was separately monitored using the grasping test (weekly), the staircase test, and noninvasive electrophysiological recordings from the thenar muscles (both every 4 weeks). Evaluation was completed by histomorphometrical analyses at 8 and 12 weeks postsurgery.ResultsThe comprehensive evaluation detected a significant difference in the recovery of forepaw functional motor ability between the ANG and MVG groups. The correlation between the different functional tests evaluated precisely displayed the recovery of distinct levels of forepaw functional ability over time.ConclusionThus, this multimodal evaluation model represents a valuable preclinical model for peripheral nerve reconstruction approaches.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

2017

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“…In spite of the effectiveness of some types of biological nerve guides, some of which have been successfully translated to the clinics (Chiu and Strauch, 1990;Pereira et al, 1991;Marcoccio and Vigasio 2010;Tos et al, 2012;Manoli et al, 2014), most research along the last 30 years has been dedicated to artificial scaffolds based on the recent advancements in bio-nanotechnologies. A number of innovative artificial nerve guides have been developed and this body of experimental research has been mainly based on experiments made using the SNI model aimed at comparing, in a pre-clinical view, the effectiveness of different types of scaffolds (Rodriguez et al, 2000;Varejao et -9 -al., 2003;Dodla and Bellamkonda, 2008;Carriel et al, 2013;Haastert-Talini et al, 2013;Reid et al, 2013;Johansson and Dahlin, 2014).…”

Section: Tubulization Reconstruction Of Substance Defectsmentioning

confidence: 99%

The sciatic nerve injury model in pre-clinical research

Geuna

2015

Journal of Neuroscience Methods

111

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In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to be carried out in animal models due to the structural complexity of this organ which can be only partly simulated in vitro. The far most used experimental model is based on the injury of the sciatic nerve, the largest nerve trunk in mammals. In this paper, the potential application of the sciatic nerve injury model in pre-clinical research is critically reviewed. This paper is aimed at helping researchers in properly employing this in vivo model for the study of nerve repair and regeneration as well as interpreting the results in a clinical translation perspective.

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“…The use of autologous nerve grafts, which promise the most predictable outcomes, has inherent problems such as potential neuroma formation, sensory loss, and tingling sensation at the donor site. Therefore, various materials have been evaluated as alternative treatments for nerve grafts, including non‐synthetic or synthetic conduits, allogenic grafts, and other autologous tissue (Beigi, Ghasemi‐Mobarakeh, Prabhakaran, et al, ; Hundepool, Bulstra, Kotsougiani, et al, ; Manoli, Schulz, Stahl, Jaminet, & Schaller, ).…”

Section: Introductionmentioning

confidence: 99%

A scaffold‐free Bio 3D nerve conduit for repair of a 10‐mm peripheral nerve defect in the rats

et al. 2019

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Introduction A Bio 3D printed nerve conduit was reported to promote nerve regeneration in a 5 mm nerve gap model. The purpose of this study was to fabricate Bio 3D nerve conduits suitable for a 10 mm nerve gap and to evaluate their capacity for nerve regeneration in a rat sciatic nerve defect model. Materials and Methods Eighteen F344 rats with immune deficiency (9–10 weeks old; weight, 200–250 g) were divided into three groups: a Bio 3D nerve conduit group (Bio 3D, n = 6), a nerve graft group (NG, n = 6), and a silicon tube group (ST, n = 6). A 12‐mm Bio 3D nerve conduit or silicon tube was transplanted into the 10‐mm defect of the right sciatic nerve. In the nerve graft group, reverse autografting was performed with an excised 10‐mm nerve segment. Assessments were performed at 8 weeks after the surgery. Results In the region distal to the suture site, the number of myelinated axons in the Bio 3D group were significantly larger compared with the silicon group (2,548 vs. 950, p < .05). The myelinated axon diameter (MAD) and the myelin thickness (MT) of the regenerated axons in the Bio 3D group were significantly larger compared with those of the ST group (MAD: 3.09 vs. 2.36 μm; p < .01; MT: 0.59 vs. 0.40 μm, p < .01). Conclusions This study indicates that a Bio 3D nerve conduit can enhance peripheral nerve regeneration even in a 10 mm nerve defect model.

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Evaluation of sensory recovery after reconstruction of digital nerves of the hand using muscle-in-vein conduits in comparison to nerve suture or nerve autografting

Abstract: Muscle-in-vein conduits may be a good alternative solution to autografts for the reconstruction of digital nerves, since no significant differences could be demonstrated between the two methods.

Cited by 49 publications

References 30 publications

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

The sciatic nerve injury model in pre-clinical research

A scaffold‐free Bio 3D nerve conduit for repair of a 10‐mm peripheral nerve defect in the rats

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