Evaluation of semisynthetic chlorophyll-a derivatives as photosensitizers in fibroblast cells
Andréia da Cruz Rodrigues,
Bruno Andrade Ono,
Erika Toneth Ponce Ayala
et al.
Abstract:In this study, we present the evaluation in fibroblast cells of photosensitizers semi-synthesized derived from chlorophyll a (as described in literature). The process began with the extraction of methyl-pheophorbide a (1), which was then reacted with primary aliphatic amines (butylamine, hexylamine, and octylamine) to yield molecules 2 to 4. Additionally, purpurin-18 methyl ester (5) was obtained through the oxidation of methyl pheophorbide a (1). By adding different aliphatic amines (butylamine, hexylamine, a… Show more
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