Evaluation of Semen Quality in Type 2 Diabetes Mellitus Sudanese Patients Compared to Non-Diabetic Subjects

Abstract

Background: Diabetes leads to metabolic abnormalities. These abnormalities produce problems in a variety of organ systems such as ophthalmopathies, neuropathies, nephropathies, and vasculopathies. Infertility is common in diabetic patients, caused by abnormal semen. Objectives: This study was conducted to check semen quality in diabetic Sudanese patients. Method: This is a retrospective cross-sectional designed study. The data were collected in a period from January 2015 to February 2017. A total of 600 individuals was included, 300 with type 2 diabetes mellitus and 300 apparently healthy as a non-diabetic. Semen analysis was performed according to WHO criteria. Results: Significant lower results were found in diabetic patients compared to non diabetic regarding the following parameters: volume of ejaculation (p = 0.047), percent motility (p = 0.001), percent normal morphology (p = 0.000), while there was no difference in the sperm count between diabetic and non-diabetic subjects. Conclusion: Semen of types 2 diabetes mellitus patients is of low volume, abnormal motility and morphology compared to non-diabetic subjects.

Consequences of Type-2 diabetes mellitus and Malaria co-morbidity on sperm parameters in men; a case-control study in a district hospital in the Ashanti Region of Ghana

“…The findings from this study revealed that the mean sperm morphology (Normal forms) of the T2DM & Malaria co-morbidity group was significantly lower when compared to the T2DM-only group and the controls. The decrease observed in the normal forms of sperm morphology of the T2DM & Malaria co-morbidity group agrees with earlier studies that reported a significant reduction in normal sperm morphology [ 3 , 4 ]. Another study conducted by Condorelli and colleagues reported a decrease in normal forms of sperm.…”

“…It is known that T2DM affects the fertility of males. Infertility is a disease of the reproductive system which is defined by the inability of couples to conceive after 12 months or more of unprotected regular sexual intercourse [3]. Male infertility could be caused by poor sperm parameters [4] such as reduced sperm motility, sperm concentration and morphology [4][5][6].…”

Impact of Diabetes and obesity on Human Fertility and Semen Quality

“…The findings showed that in DM patients, semen volume, sperm concentration, complete sperm motility, progressive sperm motility, and normal sperm morphology were considerably lower than in nondiabetic controls (Zhu et al, 2017). Semen in patients with T2 DM is of low volume, abnormal motility and morphology compared with non-diabetic subjects (Ibrahim et al, 2018). Ali et al (1993) reported a highly important increase in overall sperm count and sperm concentration in type 1 and type 2 DM patients.…”