Evaluation of Selected Physical Constants of Polymeric Films and Proposed Kinetics of Drug Release

Sciarra, John J.; Gidwani, Ram

doi:10.1002/jps.2600610517

Cited by 27 publications

(3 citation statements)

References 8 publications

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“…Although the search for effective preservatives continues unabated, esters of p-hydroxybenzoic acid are still the most frequently used preservatives in oral pharmaceutical preparations. Several recent articles discussed the conditions in which various preservatives are effective and various conditions or agents that reduced or destroyed their effectiveness (1)(2)(3).…”

Section: Discussionmentioning

confidence: 99%

Development and Evaluation of a Dexamethasone Timed‐Release Aerosol Formulation

Feinstein

Sciarra²

1975

Journal of Pharmaceutical Sciences

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Section: Discussionmentioning

confidence: 99%

Development and Evaluation of a Dexamethasone Timed‐Release Aerosol Formulation

Feinstein

Sciarra²

1975

Journal of Pharmaceutical Sciences

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“…For period of 7 days the vials were taken out and note down the weight at every 24 h intervals. The flux, i.e., the amount of water vapor transmitted through 1 cm 2 /24 h and permeability coefficient were calculated using the formula P=slope/ p ×24, where P is permeability coefficient and ‘ p ’ is the vapor pressure of saturated solution of potassium chloride[ 10 11 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and charactersiation of chitosan conjugate; design and evaluation of membrane moderated type transdermal drug delivery system

Satheeshababu¹,

Shruthinag²

2015

Indian J Pharm Sci

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The purpose of the present research investigation was to synthesis, characterisation of chitosan conjugates and its effect on drug permeation from transdermal rate controlling membrane. Chitosan conjugate was synthesised by conjugation with thioglycolic acid. The prepared chitosan conjugate was characterised by determining the charring point, Fourier transmission-infrared and differential scanning calorimetric analysis. The rate controlling membranes were prepared by various proportions of chitosan and chitosan conjugate, to moderate drug permeation through rate controlling membrane. The membrane moderated transdermal system consists of reservoir to hold the drug gel was prepared by 20% w/v ethylcellulose with a cavity in its center. An impermeable backing layer was prepared by 2% w/v ethylcellulose. Gel consists of carvedilol was prepared by sodium alginate and sodium carboxymethylcellulose in ethanol:water solvent system The rate controlling membranes prepared were evaluated by various parameters like thickness, folding endurance, swelling index, moisture content, moisture uptake, water vapor transmission rate, tensile strength test, measurement of gel strength, in vitro permeation study, ex vivo permeation study, compatibility study using differential scanning calorimetry and stability studies. All physical parameters evident that prepared membranes have good folding endurance and sufficient tensile strength. As the proportion of chitosan conjugate increases in membrane swelling index, moisture content, moisture uptake and permeability coefficient increases. The gel strength of chitosan conjugate was considerable less compared with chitosan.

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“…In a previous study, cast ethyl cellulose film was conceived as a potential matrix containing dispersed drug for an oral timed release dosage form (Donbrow & Friedman 1975a). Possible application of polymeric films as a drug delivery system for external use (Sciarra & Gidwani 1972) or for implantation into the body (Tatum et a1 1969) have already been reported. However, there is no literature on the oral use of polymeric films as drug carriers for prolonged or sustained release dosage forms.…”

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confidence: 99%

Placebo granules as cores for timed release drug delivery systems

Friedman

Donbrow

Samuelov

1979

Journal of Pharmacy and Pharmacology

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A drug delivery system is proposed constituted of spherical placebo granules as cores with polymeric surface films containing drug. This timed release dosage form has been prepared by means of a fluidized bed coating technique using ethyl cellulose as the polymeric film and caffeine and salicylic acid as model drugs. The release of the drugs from the dosage form (a) at different drug concentrations and (b) into solutions of different pH showed that drug release was linearly related to the square root of time. Good agreement was found between the theoretical release rate of caffeine, calculated according to Higuchi's equation for a homogenous matrix using membrane permeation parameters measured on linear films, and the experimental results in the case of low drug concentrations. Deviation of the release rate from the homogenous model at high drug concentrations could be explained by crystallization of the drug from the film.

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Evaluation of Selected Physical Constants of Polymeric Films and Proposed Kinetics of Drug Release

Cited by 27 publications

References 8 publications

Development and Evaluation of a Dexamethasone Timed‐Release Aerosol Formulation

Development and Evaluation of a Dexamethasone Timed‐Release Aerosol Formulation

Synthesis and charactersiation of chitosan conjugate; design and evaluation of membrane moderated type transdermal drug delivery system

Placebo granules as cores for timed release drug delivery systems

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