Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease

Kiszałkiewicz, Justyna; Majewski, Sebastian; Piotrowski, Wojciech J.; Górski, Paweł; Pastuszak-Lewandoska, Dorota; Migdalska-Sęk, Monika; Brzeziańska-Lasota, Ewa

doi:10.1038/s41598-021-01950-8

Cited by 8 publications

(5 citation statements)

References 68 publications

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“…Previous reports have supported the role of this pathway in pulmonary inflammation and COPD severity [44,45]. Notably, increased gene expression levels of IL6ST have been observed in COPD patients with exacerbation history compared to COPD patients without known exacerbation history [46]. In support of these findings, IL6ST is highly upregulated in the MOD branch, supporting the specificity of our subtypes.…”

Section: The Joint Subtypes Exhibit Distinct Transcriptomic Signature...supporting

confidence: 85%

Joint Clinical and Molecular Subtyping of Copd With Variational Autoencoders

Maiorino,

De Marzio,

et al. 2023

Preprint

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Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous disease. Traditional subtyping methods generally focus on either the clinical manifestations or the molecular endotypes of the disease, resulting in domain-specific classifications that may not capture its full complexity. Here, we introduce an integrative approach based on variational autoencoders to integrate clinical and blood gene expression data from the COPDGene cohort study. We generate Personalized Integrated Profiles (PIPs) that recapitulate the joint clinical and molecular state of each individual in the population. Through prediction experiments we show that the PIPs encode the complex disease state of each individual in a compact representation, with an accuracy comparable or better than other embedding approaches. Through these profiles we study the space of continuous variation of COPD features by using graph-based trajectory learning techniques, and delineate five well-separated subtypes. The identified subtypes exhibit distinct phenotypes, expression signatures, and disease outcomes. Overall, our findings show that integrating clinical and molecular data is beneficial for gaining a more comprehensive understanding of COPD heterogeneity.

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Section: The Joint Subtypes Exhibit Distinct Transcriptomic Signature...supporting

confidence: 85%

Joint Clinical and Molecular Subtyping of Copd With Variational Autoencoders

Maiorino,

De Marzio,

et al. 2023

Preprint

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“…Increased inflammatory cytokine and chemokine expression is commonly observed ( 15 ). IL-6 and other molecules related to IL-6 signaling are among the most consistent ( 16 , 17 ). Interestingly, IL-6 is also among the most consistent factors present in the SASP of senescent cells ( 18 ).…”

Section: Introductionmentioning

confidence: 94%

Cellular senescence is a key mediator of lung aging and susceptibility to infection

Torrance

Haynes²

2022

Front. Immunol.

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Aging results in systemic changes that leave older adults at much higher risk for adverse outcomes following respiratory infections. Much work has been done over the years to characterize and describe the varied changes that occur with aging from the molecular/cellular up to the organismal level. In recent years, the systemic accumulation of senescent cells has emerged as a key mediator of many age-related declines and diseases of aging. Many of these age-related changes can impair the normal function of the respiratory system and its capability to respond appropriately to potential pathogens that are encountered daily. In this review, we aim to establish the effects of cellular senescence on the disruption of normal lung function with aging and describe how these effects compound to leave an aged respiratory system at great risk when exposed to a pathogen. We will also discuss the role cellular senescence may play in the inability of most vaccines to confer protection against respiratory infections when administered to older adults. We posit that cellular senescence may be the point of convergence of many age-related immunological declines. Enhanced investigation into this area could provide much needed insight to understand the aging immune system and how to effectively ameliorate responses to pathogens that continue to disproportionately harm this vulnerable population.

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“…The molecule STAT3 played a crucial role in the regulation of inflammatory cytokine expression in a murine model of COPD. Furthermore, research discovered an increase in the expression of the STAT3 gene in COPD patients who smoke [ 65 ]. Additionally, the literature review provided evidence supporting the possibility of combining targets and ingredients.…”

Section: Discussionmentioning

confidence: 99%

Evidence construction of Jinshuibao capsules against stable chronic obstructive pulmonary disease: A systematic review and network pharmacology

Yin,

Wang,

Liu

et al. 2024

Heliyon

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Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease

Cited by 8 publications

References 68 publications

Joint Clinical and Molecular Subtyping of Copd With Variational Autoencoders

Joint Clinical and Molecular Subtyping of Copd With Variational Autoencoders

Cellular senescence is a key mediator of lung aging and susceptibility to infection

Evidence construction of Jinshuibao capsules against stable chronic obstructive pulmonary disease: A systematic review and network pharmacology

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