Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities
Fiona C. Kanis,
Caroline N. Broude,
Elle B. Hellwarth
et al.
Abstract:N‐methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N‐dimethyltryptamine (DMT), are gaining interest from the medical community due to their potential as next generation treatments for mental health disorders. The clinical relevance of these compounds has driven scientists to develop biosynthetic production routes to a number of tryptamine drug candidates, and efforts are ongoing to expand and further develop these biosynthetic capabilities. To that end, we have further char… Show more
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