Evaluation of <scp>E</scp>thnomedical <scp>C</scp>laim <scp>III</scp>: Anti‐hyperglycemic activities of <i><scp>G</scp>ongronema latifolium</i> root and stem (民族药物需求评估III：<i>Gongronema latifolium</i>根与茎的降糖活性)

Adebajo, AC; Ayoola, Marcus Durojaye; Odediran, Samuel Akintunde; Aladesanmi, A. J.; Schmidt, Thomas J.; Verspohl, E. J.

doi:10.1111/1753-0407.12019

Cited by 14 publications

(6 citation statements)

References 22 publications

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“…A significant (p < 0.05) time-dependent hyperglycaemia-lowering effects up to the fourth hour was observed in the negative control group of rats that were given normal saline. This activity could be attributed to the normal homeostatic regulatory mechanism in normal animals which confirmed the healthy state of the pancreases of the animals used in the study [20][21][22][23]. Also, the positive control group of rats that were administered with glibenclamide(5 mg/kg) gave a significant time-dependent antihyperglycaemic activity up to fourth hour (Table 1).…”

Section: Antihyperglycaemic Effects Of the Extractsupporting

confidence: 57%

“…The antihyperglycaemic assay of the extract, A and its partition fractions, B1-B4 were carried out in glucose-induced hyperglycaemic normal rats as described by Adebajo, Ayoola and their co-workers [20][21][22][23].…”

Section: Antihyperglycaemic Assay Of the Extract Fractionsmentioning

confidence: 99%

“…In glucose-induced antihyperglycaemic experiments of medicinal plants or orthodox drugs involving the use of glibenclamide and other insulinotropic drugs as positive controls, it has been established that results obtained from such experiments can be extrapolated on the Type 2 diabetic state in humans [20,21,24]. Furthermore, the use of glibenclamide in antidiabetic experiments as the standard drug [25] could be used to determine the early extrapancreatic and late insulin stimulating effects in terms of the mechanisms of action of the extract being investigated [22,23,26].…”

Section: Antihyperglycaemic Effects Of the Extractmentioning

confidence: 99%

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Two antihyperglycaemic compounds from Globimetula braunii (Engl.) Van Tiegh (Loranthaceae)

Ayoola

Oluwabunmi

Olatubosun

et al. 2020

GSC Biol. and Pharm. Sci.

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Large numbers of medicinal plants are constantly being screened for possible pharmacological values, especially for chronic diseases such as diabetes, with the view of discovering new compounds that may serve as templates for synthesis of more active/less toxic drugs. Therefore, the antihyperglycaemic activity of the leaf of Globimetula braunii with antidiabetic ethnomedical usage in Nigeria was investigated is this study to justify this folkloric claim. The median lethal dose, LD50 of the ethanol leaf extract of G. braunii was determined using Lorke's method and its antihyperglycaemic effect at 100, 200 and 400 mg/kg was evaluated using glucose-induced hyperglycaemic rats while glibenclamide (5 mg/kg) and 1 % Tween 80 in normal saline served as positive and negative controls, respectively. Anti-hyperglycaemic activity-directed purification of the extract of the plant in glucose-loaded rats, led to the isolation and characterisation of phyllanthone and methyl 2, 6-dihydroxy-4-methoxybenzoate from the dichloromethane partitioned fraction. The findings showed that the LD50 of the ethanol leaf extract of G. braunii was greater than 5,000 mg/kg while its 100 mg/kg was the most active dose with comparable activity (p>0.05) to the standard drug, glibenclamide. The dichloromethane and aqueous partitioned fractions of the extract were the most promising fractions. Chromatographic separations of the dichloromethane fraction yielded phyllanthone, and methyl 2, 6dihydroxy-4-methoxybenzoate that elicited comparable activity to glibenclamide (5 mg/kg) at 10 and 20 mg/kg at all time-points. The study justified the antidiabetic folkloric use of G. braunii leaf and confirmed phyllanthone and methyl 2,6-dihydroxy-4-methoxybenzoate as two of its antihyperglycaemic constituents.

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Section: Antihyperglycaemic Effects Of the Extractsupporting

confidence: 57%

Section: Antihyperglycaemic Assay Of the Extract Fractionsmentioning

confidence: 99%

Section: Antihyperglycaemic Effects Of the Extractmentioning

confidence: 99%

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Two antihyperglycaemic compounds from Globimetula braunii (Engl.) Van Tiegh (Loranthaceae)

Ayoola

Oluwabunmi

Olatubosun

et al. 2020

GSC Biol. and Pharm. Sci.

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“…Examples of these are triterpenes such as α-amyrin-3O-β-(5-hydroxy) ferulic acid, terpenoids, sesquiterpenoids and sesquiterpene. These molecules have been suggested to potentiate their anti-diabetic activity through the stimulation of insulin secretion [ 45 , 127 ]. Hence, isolation of terpenes for anti-diabetic activities could be directed toward the potentiation of insulin secretion of the pancreas.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants Used for the Traditional Management of Diabetes in the Eastern Cape, South Africa: Pharmacology and Toxicology

Odeyemi

Bradley

2018

Molecules

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The use of medicinal plants for the management of diabetes mellitus is on the rise in the developing countries, including South Africa. There is increasing scientific evidence that supports the claims by the traditional healers. In this review, we compare the families of previously reported anti-diabetic plants in the Eastern Cape by rating the anti-diabetic activity, mode of action and also highlight their therapeutic potentials based on the available evidence on their pharmacology and toxicity. Forty-five plants mentioned in ethnobotanical surveys were subjected to a comprehensive literature search in the available electronic databases such as PubMed, ScienceDirect, Google Scholar and Elsevier, by using “plant name” and “family” as the keywords for the primary searches to determine the plants that have been scientifically investigated for anti-diabetic activity. The search returned 25 families with Asteraceae highly reported, followed by Asphodelaceae and Alliaceae. Most of the plants have been studied for their anti-diabetic potentials in vivo and/or in vitro, with most of the plants having a higher percentage of insulin release and inhibition against carbohydrate digesting enzymes as compared with insulin mimetic and peripheral glucose uptake. Almost all the investigated plants also inhibit oxidative stress as part of their hypoglycemic activity with less toxicity. However, the isolation of their bioactive molecules is still lacking. This review provides a resource to enable thorough assessments of the therapeutic profiles of available medicinal plants used for the management of diabetes in the Eastern Cape, South Africa. Further studies such as the identification of the active ingredients of potent plants still need to be carried out; this may lead to new molecules in drug discovery and development.

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“…Previous report revealed that prevalence of DM in Nigeria has increased from 2.2% in 1997 to 5.0% by 2013 [4]. The high costs and adverse effects of insulin and therefore the available oral hypoglycaemic agents have necessitated increased investigations on medicinal plants used ethnomedically for the management of diabetes [8][9]. According to the WHO, over 80% of the world's population depend upon traditional sorts of medicine, largely plant based to satisfy primary health care needs [18].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Methanol Stem Bark Extracts of Sterculia Setigera and Ficus Platyphylla on Hemoglobin Glycosylation and α-amylase

Ukwuani-Kwaja¹,

Nwaogu²,

Abba³

et al. 2021

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Diabetes Mellitus is a chronic metabolic disorder characterized by hyperglycemia due to abnormal insulin secretion, action or both. The synthetic available anti-diabetic drugs exhibited various adverse effects such as diarrhea, hypoglycemia. In recent years, scientists have turned their attention towards the medicinal plants which bear the rich source of metabolites which offer specific therapeutic function in the human body without any adverse effect. Sterculia setigera and Ficus platyphylla are medicinal plants that are used to treat various diseases and including diabetes traditionally. The present study is aimed at investigating the antidiabetic activity of the S. setigera and F. platyphylla methanol stem bark extracts. Phytochemical screening was determined using the standard method. In vitro studies were carried out using αamylase and glycosylated hemoglobin inhibitory assay. The results of phytochemical constituents detected were flavonoids, Tannins, Steroids, Saponins, cardiac glycosides, Terpenoids, and Phenols. Inhibitory effects of both plant extracts were dose dependent against haemoglobin glycosylation and α-amylase. At highest concentration (25mg/ml), highest inhibitions were recorded in S. setigera (70.30%) and F. platyphylla (70.00%) which was comparable to Metformin (57. 2%). IC 50 of Sterculia setigera (3.18mg/ml) and Ficus platyphylla (5.97mg/ml) were lower than metformin (8.84 mg/ml) against hemoglobin glycosylation. At concentration of (1.0mg/ml) S. setigera (72.21%) and F. platyphylla the (70.41%) showed the highest inhibitory effect which was not significantly different (p<0.05) compared to Voglibose (83.47%). In the present study, the IC 50 of both extracts were higher (0.64 and 0.69mg/ml) and not significantly comparable to the Voglibose (0.26mg/ml). In conclusion, this study suggests that Sterculia setigera and Ficus platyphylla methanol stem bark extract possess hypoglycaemic potentials. This justifies their ethnomedicinal use for the treatment of diabetes.

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Evaluation of Ethnomedical Claim III: Anti‐hyperglycemic activities of Gongronema latifolium root and stem (民族药物需求评估III：Gongronema latifolium根与茎的降糖活性)

Abstract: The results confirm pancreatic activity as a mechanism underlying the antidiabetic action of G. latifolium and justify its ethnomedical use.

Cited by 14 publications

References 22 publications

Two antihyperglycaemic compounds from Globimetula braunii (Engl.) Van Tiegh (Loranthaceae)

Two antihyperglycaemic compounds from Globimetula braunii (Engl.) Van Tiegh (Loranthaceae)

Medicinal Plants Used for the Traditional Management of Diabetes in the Eastern Cape, South Africa: Pharmacology and Toxicology

Inhibitory Effects of Methanol Stem Bark Extracts of Sterculia Setigera and Ficus Platyphylla on Hemoglobin Glycosylation and α-amylase

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