Evaluation of safety and performance of the self balancing walking system Atalante in patients with complete motor spinal cord injury

Kerdraon, J.; Prévinaire, J G; Tucker, Maegan; Coignard, P.; Allègre, Willy; Knappen, Emmanuel; Ames, Aaron D.

doi:10.1038/s41394-021-00432-3

Cited by 13 publications

(29 citation statements)

References 27 publications

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“…The exoskeleton, Atalante ® , was developed by the French startup company Wandercraft. The exoskeleton system (Figure 1) is a lower-body exoskeleton with 12 actuated joints [32]: 3 actuated joints control the 3 planes of hip motion, a single actuated joint controls knee flexion/extension, and 2 actuated joints control ankle inversion/eversion and dorsiflexion/plantarflexion. The joints that control hip and knee motion are each actuated by a brushless DC motor.…”

Section: The Robotic Devicementioning

confidence: 99%

Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)

Bonnal

Monnet

et al. 2022

Sensors

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Force and effort are important components of a motor task that can impact rehabilitation effectiveness. However, few studies have evaluated the impact of these factors on cortical activation during gait. The purpose of the study was to investigate the relation between cortical activation and effort required during exoskeleton-mediated gait at different levels of physical assistance in healthy individuals. Twenty-four healthy participants walked 10 m with an exoskeleton that provided four levels of assistance: 100%, 50%, 0%, and 25% resistance. Functional near-infrared spectroscopy (fNIRS) was used to measure cerebral flow dynamics with a 20-channel (plus two reference channels) device that covered most cortical motor regions bilaterally. We measured changes in oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR). According to HbO2 levels, cortical activation only differed slightly between the assisted conditions and rest. In contrast, bilateral and widespread cortical activation occurred during the two unassisted conditions (somatosensory, somatosensory association, primary motor, premotor, and supplementary motor cortices). A similar pattern was seen for HbR levels, with a smaller number of significant channels than for HbO2. These results confirmed the hypothesis that there is a relation between cortical activation and level of effort during gait. This finding should help to optimize neurological rehabilitation strategies to drive neuroplasticity.

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Section: The Robotic Devicementioning

confidence: 99%

Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)

Bonnal

Monnet

et al. 2022

Sensors

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“…Es existiert eine aktuelle einfache Beobachtungsstudie aus diesem Jahr, die aus 2 Rehabilitationseinrichtungen für Patienten mit Querschnittlähmung in Frankreich insgesamt 12 Patienten (Durchschnittsalter 34 Jahre) mit Lähmungshöhe zwischen Th5 und Th12 rekrutierte 24 . Insgesamt wurden 12 1-stündige Trainingseinheiten über 3 Wochen mit dem Gerät durchgeführt.…”

Section: Neue Entwicklungen: Mobile Exoskelette (Synonyme: „Powered E...unclassified

“…Sieben der 12 Patienten absolvierten den 10-m-Gehtest in der 12. Sitzung ohne Hilfe (bei einer mittleren Gehgeschwindigkeit von 0,13 m/s), während 4 der 12 Patienten Hilfe benötigten 24 . In dieser kleinen Studie zur Erstbeschreibung des Atalante-Systems wurde gezeigt, dass zumindest die Therapie relativ sicher ist und die Ausführung von Gehtraining bei Patienten mit vollständiger Querschnittlähmung ermöglicht.…”

Section: Neue Entwicklungen: Mobile Exoskelette (Synonyme: „Powered E...unclassified

Exoskelette und Gehtraining

Mehrholz¹,

Elsner²

2022

neuroreha

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“…The ReWalk (ReWalk Robotics, Yoknaem, Israel) was the first lower extremity device to receive Food and Drug Administration (FDA) approval in 2014, followed by the Ekso (Ekso Bionics, Richmond, CA) and Indego (Parker Hannifin, Cleveland, OH) in 2016, and the Keeogo (B-temia Inc., Quebec City, Canada) in 2020. Prior studies have demonstrated the ability of individuals with neurological disorders who have partial impairments to those who are completely non-ambulatory to walk independently in robotic exoskeletons [8][9][10][11][12][13][14][15][16][17][18][19]. Exoskeletal-assisted locomotion (EAL) has been shown to improve functional and motor recovery [8], mobility [9,10,15,16], chronic pain [20], muscle spasticity [20][21][22], cardiovascular health [13,23], bowel function [24], bladder function [21,22], and quality of life [21].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the dynamics of exoskeletal-assisted and unassisted locomotion in an FDA-approved lower extremity device: Controlled experiments and development of a subject-specific virtual simulator

Chandran

Nam²,

Hexner³

et al. 2023

PLoS ONE

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Robotic exoskeletons have considerable, but largely untapped, potential to restore mobility in individuals with neurological disorders, and other conditions that result in partial or complete immobilization. The growing demand for these devices necessitates the development of technology to characterize the human-robot system during exoskeletal-assisted locomotion (EAL) and accelerate robot design refinements. The goal of this study was to combine controlled experiments with computational modeling to build a virtual simulator of EAL. The first objective was to acquire a minimum empirical dataset comprising human-robot kinematics, ground reaction forces, and electromyography during exoskeletal-assisted and unassisted locomotion from an able-bodied participant. The second objective was to quantify the dynamics of the human-robot system using a subject-specific virtual simulator reproducing EAL compared to the dynamics of normal gait. We trained an able-bodied participant to ambulate independently in a Food and Drug Administration-approved exoskeleton, the ReWalk P6.0 (ReWalk Robotics, Yoknaem, Israel). We analyzed the motion of the participant during exoskeletal-assisted and unassisted walking, sit-to-stand, and stand-to-sit maneuvers, with simultaneous measurements of (i) three-dimensional marker trajectories, (ii) ground reaction forces, (iii) electromyography, and (iv) exoskeleton encoder data. We created a virtual simulator in OpenSim, comprising a whole-body musculoskeletal model and a full-scale exoskeleton model, to determine the joint kinematics and moments during exoskeletal-assisted and unassisted maneuvers. Mean peak knee flexion angles of the human subject during exoskeletal-assisted walking were 50.1° ± 0.6° (left) and 52.6° ± 0.7° (right), compared to 68.6° ± 0.3° (left) and 70.7° ± 1.1° (right) during unassisted walking. Mean peak knee extension moments during exoskeletal-assisted walking were 0.10 ± 0.10 Nm/kg (left) and 0.22 ± 0.11 Nm/kg (right), compared to 0.64 ± 0.07 Nm/kg (left) and 0.73 ± 0.10 Nm/kg (right) during unassisted walking. This work provides a foundation for parametric studies to characterize the effects of human and robot design variables, and predictive modeling to optimize human-robot interaction during EAL.

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Evaluation of safety and performance of the self balancing walking system Atalante in patients with complete motor spinal cord injury

Cited by 13 publications

References 27 publications

Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)

Relation between Cortical Activation and Effort during Robot-Mediated Walking in Healthy People: A Functional Near-Infrared Spectroscopy Neuroimaging Study (fNIRS)

Exoskelette und Gehtraining

Comparison of the dynamics of exoskeletal-assisted and unassisted locomotion in an FDA-approved lower extremity device: Controlled experiments and development of a subject-specific virtual simulator

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