Abstract:The efficacy of human amniotic mesenchymal stem cells (hAMSCs) ovarian injection for improving ovarian function of POI (Premature ovarian failure) patients has been showed in some reports. However, the safety and efficacy of the hAMSCs vein injection remains unclear. In this study, we evaluate the safety and efficacy of hAMSCs intravenous injection in cynomolgus macaques and SD rats, and to provide the evidence for clinical trials. The hAMSCs were transplanted three times in SD rats at low, medium and high dos… Show more
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