Evaluation of Rubus grandifolius L. (wild blackberries) activities targeting management of type-2 diabetes and obesity using in vitro models

Spínola, Vítor; Pinto, Joana; Llorent‐Martínez, Eulogio J.; Tomás, Helena; Castilho, Paula C.

doi:10.1016/j.fct.2018.11.006

Cited by 54 publications

(43 citation statements)

References 42 publications

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“…When carbohydrates are ingested they are broken down by enzymes, including glucosidases and amylases, into monosaccharides. A type-2 diabetic could possibly prevent hyperglycemic complications by having the ingested carbohydrates remain intact, which Spínola et al (2019) was able to demonstrate in vitro. When exposed to blackberry extracts (especially those rich in C3G), glucosidases, but not amylases, were significantly inhibited.…”

Section: Diabetes and Obesitymentioning

confidence: 89%

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Blackberry polyphenols: Composition, quantity, and health impacts from in vitro and in vivo studies

Robinson¹,

Bierwirth²,

Greenspan³

et al. 2020

JFB

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Blackberries possess marked concentrations of antioxidant polyphenols, most notably anthocyanins, ellagic acid, ellagitannins, epi/catechin, and proanthocyanidins. While the quantity and type of polyphenols can vary, cyanidin-3-O-glucoside (C3G) is consistently the most abundant polyphenol found in blackberries. Though blackberry antioxidants have not demonstrated significant bioavailability or bioaccessibility in their native form, emerging research suggests that antioxidant metabolites, such as protocatechuic acid derived from C3G, may account for some of the in vivo benefits. Cell studies conducted with blackberry phenolic extracts have demonstrated anti-inflammatory, chemopreventive, and neuroprotective effects; whereas, animal models given blackberries have exhibited reduced insulin resistance, attenuated weight gain, and a decrease in inflammatory markers. Blackberry consumption can lead to positive health outcomes. In human health cross-sectional and longitudinal studies, fresh berry consumption has been associated with better long-term insulin resistance, cognitive function, bone density, and cardiovascular function. Research studies, combining in vitro digestion and absorption with targeted cell studies, are being performed to better understand the metabolism and bioactivity of blackberry phenolics. These compounds are not only absorbed by the body, but also can attach to the lining of the digestive tract or be fermented in the colon, contributing to the health outcomes afforded by blackberry consumption.

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Section: Diabetes and Obesitymentioning

confidence: 89%

“…When exposed to blackberry extracts (especially those rich in C3G), glucosidases, but not amylases, were significantly inhibited. Protection from oxidative stress was also improved by a blackberry extract (Spínola et al, 2019).…”

Section: Diabetes and Obesitymentioning

confidence: 98%

Blackberry polyphenols: Composition, quantity, and health impacts from in vitro and in vivo studies

Robinson¹,

Bierwirth²,

Greenspan³

et al. 2020

JFB

View full text Add to dashboard Cite

show abstract

“…Spìnola and co-workers evaluated the ability of Rubus grandifolius L. methanolic extracts to inhibit glucosidases (α-, β-), α-amylase, and lipase enzymes [42]. R. grandifolius samples, wild berries (fully ripe) and leaves, were collected in two different locations.…”

Section: In Vitro and In Vivo Effects On Carbohydrate Metabolismmentioning

confidence: 99%

A Review of Biologically Active Natural Products from Mediterranean Wild Edible Plants: Benefits in the Treatment of Obesity and Its Related Disorders

2020

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Wild foods constitute an essential component of people’s diets around the world. According to the Food and Agriculture Organization (FAO), over 100 million people in the EU consume wild foods, while 65 million collect some form of wild food themselves. The Mediterranean basin is a biodiversity hotspot of wild edible species. Nowadays, due to the renewed interest in alimurgic plants and the recent findings on the beneficial role of their phytochemical constituents, these species have been defined as “new functional foods”. Research on natural products has recently regained importance with the growing understanding of their biological significance. Botanical food supplements marketed for weight and fat loss in obese subjects will be one of the most important items in marketed nutraceuticals. The aim of this report was to review the phytochemical compounds of Mediterranean wild edible species and their therapeutic potential against obesity and its related disorders. Results on the in vitro and in vivo activity of the most interesting plant extracts and their bioactive components are presented and discussed. The most interesting discoveries on their mechanisms of action are reported as well. Overall, this contribution highlights the importance and beneficial health roles of wild edible species.

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“…Godos et al [4], in a meta-analysis, reported that dietary intake of anthocyanins (contained in pomegranate juice and berries) was associated with 8% reduction in risk of hypertension, when comparing highest versus lowest exposure, whereas intakes of total flavonoids or other subclasses showed a non-significant association. In addition to the suggested mechanisms for cyanidin 3-O-glucoside antihypertensive effect [4], cyanidin 3-O-glucoside was identified as one of the main hypoglycemic and hypolipidemic agents in wild blackberry extracts [5]. Cyanidin 3-O-glucoside showed a strong inhibitory activity on pancreatic lipase, higher than orlistat (commercial drug), and an acarbose-like effect [5].…”

mentioning

confidence: 99%

“…In addition to the suggested mechanisms for cyanidin 3-O-glucoside antihypertensive effect [4], cyanidin 3-O-glucoside was identified as one of the main hypoglycemic and hypolipidemic agents in wild blackberry extracts [5]. Cyanidin 3-O-glucoside showed a strong inhibitory activity on pancreatic lipase, higher than orlistat (commercial drug), and an acarbose-like effect [5]. These antinutrient effects could have pharmacological application for controlling hyperglycemia and hyperlipidemia.…”

mentioning

confidence: 99%

Dietary Antioxidants: Micronutrients and Antinutrients in Physiology and Pathology

Peluso¹

2019

Antioxidants

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Evaluation of Rubus grandifolius L. (wild blackberries) activities targeting management of type-2 diabetes and obesity using in vitro models

Cited by 54 publications

References 42 publications

Blackberry polyphenols: Composition, quantity, and health impacts from in vitro and in vivo studies

Blackberry polyphenols: Composition, quantity, and health impacts from in vitro and in vivo studies

A Review of Biologically Active Natural Products from Mediterranean Wild Edible Plants: Benefits in the Treatment of Obesity and Its Related Disorders

Dietary Antioxidants: Micronutrients and Antinutrients in Physiology and Pathology

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