“…The variations in root canal morphology especially in the mandibular first premolars is more likely to be found in Asian, European, American, or African 5 , 6 , 17 , 18 , 20 , 22 , 23 , 24 at a higher prevalence than in the Middle East (or nearby) population. 26 , 27 , 28 However, the high prevalence at 17–29% of multiple root canals in the mandibular premolars of Iranian has been reported in a systematic review. 29 The prevalence of multiple root canals and C-shaped root canals in the mandibular first and second premolars from CBCT or micro-CT of other nationalities in the recently observational studies have been collected and presented in Table 3 .…”