Evaluation of robustly optimised intensity modulated proton therapy for nasopharyngeal carcinoma

Abstract

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Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

“…Although the effect of variations is not known until end of treatment, the good indications of accumulated target dose coverage and robustness in our study, suggest that a relaxed threshold for adaptation can be employed. Scandurra et al [39] reported similar results regarding robustness of proton plans but for nasopharyngeal carcinoma.…”

Technical note: Evaluation of deep learning based synthetic CTs clinical readiness for dose and NTCP driven head and neck adaptive proton therapy

“…Clinical treatment plans were generated in our treatment planning system (RaySearch, Sweden) and usually consisted of four beam orientations (two anterior, two posterior). IMPT plans were generated according to the description previously published by Scandurra et al in nasophayrngeal carcinoma, with the exception that 4−5 beam directions were used in HN indications other than nasopharyngeal carcinoma 25 . For 16 patients a treatment plan adaptation was performed during treatment course.…”

Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges

“…Significant weight loss appeared to have the largest impact on grade 2 or higher xerostomia NTCP. The authors conclude that robustly optimized IMPT plans, in combination with volumetric verification imaging and adaptive planning, provide adequate target coverage and acceptable OAR dose variation [ 94 ]. The results of this series might not be generally translatable, given the fact that NPC patients might experience less weight loss compared to other HNC locations.…”