Evaluation of robot automated drug dissolution measurements

Abstract

A controlled study was conducted to evaluate the feaslblllty of robotlc automatlon of routlne regulatory drug dlssolutlon measurements. A commercially available laboratory robot system automated a number of dlssolutlon analyses while concurrent manually acquired samples were analyzed by the same analytlcal method. Five welltharacterlzed drug tablet types were employed, lncludlng the two current "Unlted States Pharmacopeia" (USP) Method I I calibrators, These tablet types spanned a range of dlslntegratlon and dlssolutlon rates. I n all, over 150 tablets were analyzed. The results were subjected to a statlstlcal analysls of varlance ( ANOVA).ARer some small sources of systematic blas were eliminated, the results obtained by the robot were statlstlcally lndistlngulshable from the manual results. Addltlonally, the overall ranges of total drug dissolved were comparable to those obtalned from a dlssolutlon Interlaboratory collaborative study and to range llmlts for the USP calibrator tablets.

Simultaneous Spectrophotometric Determination of Paracetamol and p-Aminophenol in Pharmaceutical Products with Tiron Using Dissolved Oxygen as Oxidant

“…Several analytical methods have been reported in the literature for the determination of paracetamol and p-aminophenol in pure form and pharmaceutical products such as fluorimetry [4,5], volumetry [6], Fourier transform infrared spectrometry [7], chromatography [8,9], flow injection [10], and several forms of spectrophotometry [11][12][13]. Recently, articles have been pub- 1 This article was submitted by the authors in English.…”

Flow injection analysis of paracetamol using a biomimetic sensor as a sensitive and selective amperometric detector

“…Many analytical methodologies, using both batch and flow modes, have been proposed for the determination of paracetamol, including titrimetry, 18 spectrophotometry (spectrofluorimetry, near infrared reflectance spectrometry, Raman spectrometry and Fourier transform infrared spectrophotometry), [19][20][21][22][23][24][25][26] chromatography, 27,28 chemiluminescence [29][30][31] and enzymatic analysis. 32,33 Electrochemical methods [34][35][36] are an attractive alternative, since they are fast, inexpensive, and can be adapted for portable, disposable and miniaturized applications.…”

Cetus 840®: A New Paradigm for a Modernized Fully Automated Dissolution System

“…Although these systems were introduced approximately 20 to 30 years ago [9], the state of the art fully automated dissolution test systems have seen minor improvements, and very few "new" automated dissolution systems have been introduced in the last 10 years [10][11][12]. Thus, demand has been building for a novel approach in designing a dissolution system which incorporates many of the advances that have been made in the last decade.…”