Abstract:Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood–brain barrier, has limited effectiveness in treating viruses affecting the central nervous system. Direct nose-to-brain delivery was investigated for ribavirin in combination with poloxamer 188, an excipient known to enhance the absorption of drug compounds administered intranasally. Composite solid microparticles suitable for intranasal insufflation were prepared by suspending fine crystals of ribavirin in a matri… Show more
“…Diverse formulation approaches in nasal drug delivery have been presented, including development of binary composite solid microparticles [1], nanovesicular systems [2] and microsphere/inert carrier dry powder platform [3], all designed for direct nose-to-brain delivery of the incorporated drug.…”
mentioning
confidence: 99%
“…Vasa et al [1] developed binary composite solid microparticles of the antiviral drug ribavirin and poloxamer as a nasal permeation enhancer. The preparation method included the suspension of fine crystals of ribavirin in a molten matrix of poloxamer, quenching using liquid nitrogen and cryogenic milling.…”
“…Diverse formulation approaches in nasal drug delivery have been presented, including development of binary composite solid microparticles [1], nanovesicular systems [2] and microsphere/inert carrier dry powder platform [3], all designed for direct nose-to-brain delivery of the incorporated drug.…”
mentioning
confidence: 99%
“…Vasa et al [1] developed binary composite solid microparticles of the antiviral drug ribavirin and poloxamer as a nasal permeation enhancer. The preparation method included the suspension of fine crystals of ribavirin in a molten matrix of poloxamer, quenching using liquid nitrogen and cryogenic milling.…”
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