Evaluation of Ribavirin Genotoxicity with Sister Chromatid Exchange and Micronuclei Assays in Humans

Tatar, Abdülgani; Özkurt, Zülal; Hacımüftüoğlu, Ahmet; Ahmet, Yesilyurt; Vançelik, Serhat

doi:10.3906/sag-0804-26

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Besides the heterogeneity of chromosome disorder, the test also requires quite a high amount of time and cost thus this defect is rarely checked. Nowadays, the ATR signaling pathway becomes the most pathway event though ATR genes are not only defects [3].…”

Section: Discussionmentioning

confidence: 99%

Case of Seckel Syndrome in a 9-month-old Girl

Kelana

Windiani

Arimbawa

et al. 2023

Open Access Maced J Med Sci

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INTRODUCTION: Seckel syndrome is a rare case. It belongs to an autosomal recessive disorder. It commonly leads to osteodysplastic, microcephaly, and dwarfism, which are proportional to prenatal onset. Microcephaly, bird-headed-like appearance, and mental retardation are common dysmorphic in the future. This case report present a patient with Seckel syndrome and this case will be discussed comprehensively. CASE REPORT: A patient 9-month-old girl came to the hospital with a chief complaint of growth disturbance. Her growth was not the same as her peer. She was stunted and failed to thrive. Microcephaly and a dysmorphic face (bird-headed) appeared with a broad face, prominent forehead, large eyes, prominent curved nose, and micrognathia were found in physical examination. Her organ was in normal condition. According to the radiology examination, the bone age was appropriate for the age of a newborn (<3 months). Patient had global developmental delay. Based on clinical manifestation patient can be witnessed with Seckel syndrome, to confirm the diagnosis chromosomal test is needed. There is no specific treatment. Management for the patient was growth and developmental intervention. CONCLUSION: Seckel syndrome is a rare disease. The diagnosis was challenging and sometimes could miss diagnosed with another syndrome. In this case, the diagnosis was made by clinical presentation and laboratory examination. There was no specific treatment. We assess the patient with Seckel syndrome. A gene or chromosome examination is needed. Meanwhile, the examination was limited and need a high cost. Educating the family about the patient’s condition has been done.

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Section: Discussionmentioning

confidence: 99%

Case of Seckel Syndrome in a 9-month-old Girl

Kelana

Windiani

Arimbawa

et al. 2023

Open Access Maced J Med Sci

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Genotoxic effects of banding procedure with different orthodontic cements on human oral mucosa cells

Öztürk¹,

Yüksel²,

Toy³

et al. 2012

Turkish Journal of Medical Sciences

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The in vitro determination of genotoxicity in peripheral lymphocytes of welders exposed to fumes from metal-arc welding

Şener¹,

Eroğlu

2013

Turk J Med Sci

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To foster the practical development of the constructed wetlands used for water quality enhancement in Turkey, 2 vertical subsurface flow pilot-scale constructed wetlands were implemented on the METU campus, Ankara, Turkey. Both of the wetlands were planted with Phragmites australis and operated identically at a flowrate of 3 m 3 .d −1 and a hydraulic loading rate (HLR) of 0.100 m.d −1 , intermittently. The main objective of the research was to quantify the effect of different substrates (gravel and blast furnace granulated slag) on the nutrient removal performance of the constructed wetlands in the prevailing climate of Ankara. According to the monitoring study (July 2002-January 2003), concentration based average removal efficiencies for the slag and gravel reed beds were as follows: TSS (64% and 62%), COD (49% and 40%), NH + 4 -N (88% and 58%), TN (41% and 44%), TP (63% and 9%) and PO 3− 4 -P (60% and 4%). In general, the treatment performance of the slag system was better than that of the gravel system.

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Evaluation of Ribavirin Genotoxicity with Sister Chromatid Exchange and Micronuclei Assays in Humans

Cited by 4 publications

References 26 publications

Case of Seckel Syndrome in a 9-month-old Girl

Case of Seckel Syndrome in a 9-month-old Girl

Genotoxic effects of banding procedure with different orthodontic cements on human oral mucosa cells

The in vitro determination of genotoxicity in peripheral lymphocytes of welders exposed to fumes from metal-arc welding

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