Abstract:Annona squamosa is a medicinal plant which has been used in alternative medicine from ancient times. Different parts of Annona squamosa such as fruits, seeds, leaves and barks have been used to treat many diseases. Some of the active constituents have been identified and investigated for biological actions while the rest are yet to be explored. Current understanding of pharmacological properties of Annona squamosa not only supports alternative medicine but also contributes to the development of potential drugs for certain diseases. Therefore, an updated review on pharmacological actions of Annona squamosa is in urgent need. The purpose of this review is to provide current understanding of important pharmacological properties of Annona squamosa. The information provided in this article could be used to proceed to the designation and development of new pharmacological agents prepared from Annona squamosa for commonly encountered diseases.