Evaluation of Retinal Nerve Fiber Layer Thickness with Spectral Domain Oct in Primary Open Angle Glaucoma and Ocular Hypertension

Abstract

Purpose:To compare Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OHT) and control groups by using Visual Field (VF) and Spectral Domain Optical Coherence Tomography (SD-OCT) and to investigate correlations between VF global indices and Retinal Nerve Fiber Layer (RNFL) thickness measurements.Methods: Forty patients with POAG, 55 patients with OHT, and 40 normal subjects were included in the study. All subjects were evaluated by standard automated perimetry and Cirrus HD-OCT.Results: RNFL global average thickness, average thicknesses in four quadrants and at 1 o'clock, 4 o'clock, 5 o'clock, 6 o'clock, 7 o'clock, 10 o'clock, 11 o'clock and 12 o'clock areas in POAG patients were significantly decreased compared with the OHT and the control groups. RNFL thicknesses at 2 o'clock, 8 o'clock and 9 o'clock areas in the POAG group were significantly lower than control subjects. There were statistically significant and a negative correlation between PSD and RNFL global average thickness, RNFL thicknesses in temporal quadrant and at 1 o'clock and 2 o'clock areas in the POAG group. According to the areas under the ROC curve, the parameter which has the best diagnostic ability was found as RNFL thickness in the superior quadrant. The sensitivity and specificity of Cirrus HD-OCT for RNFL thickness in superior quadrant were found 77% and 87%. Conclusion:The correlations between MD, PSD and RNFL thickness parameters could represent the consistency of functional and structural tests. RNFL measurement with SD-OCT could provide important information for detection of early stages of glaucoma.

Evolutionary Study of the Retinal Nerve Fiber Layer for the Patients with Glaucoma and Diabetes Mellitus

“…More studies showed the importance of the OCT evaluation in the early diagnosis of glaucoma [5,6,7,8]. Sahli and co-workers [6], in a comparative study that included 40 glaucoma patients, 55 intraocular hypertension patients and 40 normal subjects, following the evaluation of the retinal nerve fiber layer using OCT, found that the global thickness and on the sectors of the retinal nerve fiber layers was significantly lower as compared to those patients with intraocular hypertension and normal subjects. He also found that there was a positive correlation between the thickness of the RNFL and the visual field results.…”

“…Several studies showed that the measurement of the thickness of the retinal nerve fiber layer was an important parameter in the early diagnosis of glaucoma [5,6]. Fig.…”