Evaluation of retinal nerve fiber layer thickness in diabetic retinopathy by optical coherence tomography after full scatter panretinal argon laser photocoagulation

Wagdy, Faried M; Sobky, Hoda M El; Sarhan, Abd El-Rahman E; Hafez, Mohammed A

doi:10.4103/2090-0686.127365

Cited by 3 publications

(2 citation statements)

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“…On the other hand, Tso et al have demonstrated that the high-intensity laser beam results in the damage of the entire retinal layer, including the retinal ganglion cells [31]. In addition, the reduction in the RNFL thickness by apoptosis of neuronal cells, and the damage due to glycosylation end products of diabetes also play a role [32][33][34][35]. The interplay of these heterogeneous factors which results in the final impact of PRP on the RNFL, in any individual patient, was possible.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis to study the effect of pan retinal photocoagulation on retinal nerve fiber layer thickness in diabetic retinopathy patients

Wadhwani¹,

Bhartiya²,

Upadhaya³

et al. 2020

RJO

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Background. Diabetic retinopathy is a microvascular disease, it is associated with changes in peripapillary retinal nerve fiber layer thickness, these changes being more pronounced in PDR (Proliferative diabetic retinopathy) patients undergoing laser photocoagulation. Objective. To assess changes in peripapillary retinal nerve fiber layer thickness in proliferative diabetic retinopathy patients using optical coherence tomogram (OCT). Methods. The database search was conducted in June 2018 and continued until October 2018. The search engines used included Pubmed, Medline, OVID and Google Scholar. A meta-analysis of weighted mean difference and standard deviation was conducted. Results. A total of 10 studies containing 377 eyes of PDR patients were selected. The analysis of the included studies revealed no significant effect of PRP on average retinal nerve fiber layer thickness (0.249, 95% CI: -0.985 to 1.483) using OCT. Conclusion. Hence, to conclude, our meta-analysis revealed that there was no significant effect of PRP on RNFL thickness and the impact of PRP could vary. Measurement of peripapillary RNFL thickness may yield erroneous and unpredictable results in this subgroup of patients, further confounding the evaluation of nerve fiber layer damage and its progression.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis to study the effect of pan retinal photocoagulation on retinal nerve fiber layer thickness in diabetic retinopathy patients

Wadhwani¹,

Bhartiya²,

Upadhaya³

et al. 2020

RJO

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“…Although PRP has been proven to be an effective treatment strategy for severe diabetic retinopathy, most ophthalmologists agree that the laser intensity causes damage to the entire retinal layer and should be avoided [ 15 ]. If the high-intensity laser beam causes the destruction of the entire retinal layer, including the GCL, it will result in a loss of RNFL and cause a sequential decrease in the RNFL thickness [ 3 13 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Macular Retinal Layers and Peripapillary Nerve Fiber Layer Thickness after 577-nm Pattern Scanning Laser in Patients with Diabetic Retinopathy

Shin

Lee

2017

Korean J Ophthalmol

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PurposeThe aim of this study was to evaluate the changes in thickness of each macular retinal layer, the peripapillary retinal nerve fiber layer (RNFL), and central macular thickness (CMT) after 577-nm pattern scanning laser (PASCAL) photocoagulation in patients with diabetic retinopathy.MethodsThis retrospective study included 33 eyes with diabetic retinopathy that underwent 577-nm PASCAL photocoagulation. Each retinal layer thickness, peripapillary RNFL thickness, and CMT were measured by spectral-domain optical coherence tomography before 577-nm PASCAL photocoagulation, as well as at 1, 6, and 12 months after 577-nm PASCAL photocoagulation. Computerized intraretinal segmentation of optical coherence tomography was performed to identify the thickness of each retinal layer.ResultsThe average thickness of the RNFL, ganglion cell layer, inner plexiform layer, inner nuclear layer, inner retinal layer, and CMT at each follow-up increased significantly from baseline (p < 0.001), whereas that of the retinal pigment epithelium at each follow-up decreased significantly from baseline (p < 0.001). The average thickness of the peripapillary RNFL increased significantly at one month (p < 0.001). This thickness subsequently recovered to 7.48 µm, and there were no significant changes at six or 12 months compared to baseline (p > 0.05).ConclusionsEach macular retinal layer and CMT had a tendency to increase for one year after 577-nm PASCAL photocoagulation, whereas the average thickness of retinal pigment epithelium decreased at one-year follow-up compared to the baseline. Although an increase in peripapillary RNFL thickness was observed one month after 577-nm PASCAL photocoagulation, there were no significant changes at the one-year follow-up compared to the baseline.

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Changes in Peripapillar Retinal Nerve Fiber Layer Analized by Td-Oct in Patients with Diabetic Retinopathy That Receive Panretinal Photocoagulation

Hernandez¹

2018

IJOVS

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In this study, changes in Retinal Nerve Fiber Layer (RNFL) within peripapillar zone in patients with diabetic retinopathy that accomplish criteria to receive panretinal photocoagulation are analyzed by TD-OCT (Time Domain-Optic Coherence Tomography) unit. This analysis was transversal retrospective and observational and was done in 46 eyes from 33 patients. According to laser application technique, time since application and day of the study, 4 groups of patients were set: the first with patients with less than 30 days since last laser application and day of study. The second with patients with 180 days since laser photocoagulation; the last two groups received panretinal photocoagulation plus macular selective laser with a TD-OCT performed 30 days (for the third group) and 180 days (the fourth group) after administration of treatment. The clinically significant finding was in comparing the group that received panretinal photocoagulation with TD-OCT after 30 days, and the group that received panretinal photocoagulation and TD-OCT after 180 days. Average thickness was less in the second group, with a statistical significant finding p=0.012 in inferior quadrant. Administer laser photocoagulation makes changes in the structure and function of the retina, and according to references many different results may be possible taking in count the equipment used to apply treatment and to take measurements. The patient must be informed about secondary and adverse effects after the treatment

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Evaluation of retinal nerve fiber layer thickness in diabetic retinopathy by optical coherence tomography after full scatter panretinal argon laser photocoagulation

Cited by 3 publications

References 0 publications

A meta-analysis to study the effect of pan retinal photocoagulation on retinal nerve fiber layer thickness in diabetic retinopathy patients

A meta-analysis to study the effect of pan retinal photocoagulation on retinal nerve fiber layer thickness in diabetic retinopathy patients

Changes in Macular Retinal Layers and Peripapillary Nerve Fiber Layer Thickness after 577-nm Pattern Scanning Laser in Patients with Diabetic Retinopathy

Changes in Peripapillar Retinal Nerve Fiber Layer Analized by Td-Oct in Patients with Diabetic Retinopathy That Receive Panretinal Photocoagulation

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