Evaluation of retinal alterations in Parkinson disease and tremor diseases

Tuğcu, Betül; Melikov, Arif; Yildiz, Gulsen Babacan; Gökçal, Elif; Ercan, Rukiye; Uysal, Ömer; Özdemir, Hakan

doi:10.1007/s13760-019-01228-x

Cited by 14 publications

(20 citation statements)

References 26 publications

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“…The 36 studies were all published between 2011 and 2020. The flow diagram of the search procedure is shown in Figure 1 and the characteristics of the included studies are described in Table 1 [11,19–53]. Patients with PD had a mean age of 64.8 (53.4–74.61) years and a mean duration of 6.7 (0.675–18.44) years.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the OCT models, 15 studies used the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) [19,20,22,24,26–28,34,36,44–46,50,52,53], 13 studies used the Cirrus OCT (Carl Zeiss Meditec, Dublin, CA, USA) [11,29–31,33,35,38,39,41,42,48,49,51] and eight studies used other OCT models [21,23,25,32,37,40,43,47]. In the included studies for the meta‐analysis, 32 studies measured pRNFL thickness [11,19–22,24,26–31,33,35–53], 14 measured macular thickness [11,21,24,27,29,32–34,39,43,45,46,48,50], nine measured macular volume [11,20,21,24,29,33,38,41,48] and 11 measured mGCC thickness [11,19,23,32,35,36,39,41,42,47,51]. Details of the risk of bias assessment are provided in Appendix S1, Table S2.…”

Section: Resultsmentioning

confidence: 99%

“…Patients with PD had a mean age of 64.8 (53.4-74.61) years and a mean duration of 6.7 (0.675-18.44) years. Amongst these studies, 18 were carried out in Europe [19,21,24,26,27,30,[35][36][37]39,41,[43][44][45][46]48,49,53], 15 in Asia [11,22,23,25,28,29,[31][32][33][34]42,47,[50][51][52] and three in America [20,38,40]. All the studies excluded participants S2.…”

Section: Overall Characteristics Of Selected Trials and Quality Assessmentmentioning

confidence: 99%

“…Regarding the OCT models, 15 studies used the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany)[19,20,22,24,[26][27][28]34,36,[44][45][46]50,52,53], 13 studies used the Cirrus OCT (Carl Zeiss Meditec, Dublin, CA, USA)[11,[29][30][31]33,35,38,39,41,42,48,49,51] and eight studies used other OCT models[21,23,25,32,37,40,43,47]. In the included studies for the meta-analysis, 32 studies measured pRNFL thickness[11,[19][20][21][22]24,[26][27][28][29][30][31]33,[35]…”

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confidence: 99%

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Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: A systematic review and meta‐analysis

Zhou

Tao

2020

Euro J of Neurology

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Background and purpose Retinal pathological changes may precede or accompany the deterioration of brain tissue in Parkinson's disease (PD). The purpose of this meta‐analysis was to assess the usefulness of optical coherence tomography (OCT) measurements as potential imaging biomarkers for PD. Methods PubMed, Embase, Web of Science and Cochrane Library databases were systematically searched for observational studies (published prior to 30 May 2020) comparing the OCT measurements between PD patients and healthy controls (HCs). Our main end‐points were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell complex thickness, macular thickness and macular volume. Pooled data were assessed by use of a random‐effects model. Results A total of 36 observational studies were identified that included 1712 patients with PD (2548 eyes) and 1778 HCs (2646 eyes). Compared with the HC group, the PD group showed a significant reduction in mean pRNFL thickness (weighted mean difference [WMD] −3.51 μm, 95% confidence interval [CI] −4.84, −2.18; p = 0.000), all quadrants at the pRNFL (WMD range −7.65 to −2.44 μm, all p < 0.05), macular fovea thickness (WMD −5.62 μm, 95% CI −7.37, −3.87; p = 0.000), all outer sector thicknesses at the macula (WMD range −4.68 to −4.10 μm, all p < 0.05), macular volume (WMD −0.21 mm3, 95% CI −0.36, −0.06; p < 0.05) and macular ganglion cell complex thickness (WMD −4.18 μm, 95% CI −6.07, −2.29; p < 0.05). Conclusions Our pooled data confirmed robust associations between retinal OCT measurements and PD, highlighting the usefulness of OCT measurements as potential imaging biomarkers for PD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Overall Characteristics Of Selected Trials and Quality Assessmentmentioning

confidence: 99%

mentioning

confidence: 99%

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Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: A systematic review and meta‐analysis

Zhou

Tao

2020

Euro J of Neurology

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“…The previous results are inconsistent on the results of decreased thickness of pRNFL, especially in different retinal quadrants and sectors. Most of the studies reported that the average thickness of pRNFL decreased in PD patients compared to healthy controls [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], some reported no significant decrease [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Only three studies reported that the pRNFL thickness of average and all four quadrants decreased in PD patients compared to healthy controls [11,19,20], while four studies reported that neither the average thickness of pRNFL nor the thickness of four quadrants decreased [25,28,32,35].…”

Section: Introductionmentioning

confidence: 99%

The specific pattern of retinal nerve fiber layer thinning in Parkinson’s disease: a systematic review and meta-analysis

Huang

Wang

et al. 2020

J Neurol

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Background and purposeThe peripapillar nerve fiber layer (pRNFL) thinning in different retinal quadrants or sectors remains controversy. We conducted a systematic review and meta-analysis on the pattern of pRNFL thinning in Parkinson's disease (PD) patients to provide a biomarker for PD differential diagnosis. Methods We systematically searched PubMed and EMBASE to identify studies comparing pRNFL thickness in PD patients and health controls using spectral domain-optical coherence tomography from inception to April 25, 2020. Random effects mode was used to pool mean difference (μm) of the average thickness of pRNFL and the thickness of pRNFL in four quadrants (superior, inferior, nasal and temporal) and in the subdivisions of superior (superonasal and superotemporal sectors) and inferior quadrants (inferonasal and inferotemporal sectors) between PD patients and health controls. Results We included 32 studies (33 sets of data) enrolling 2126 PD eyes and 2318 health control eyes. Between the eyes of PD patients and that of health controls, the pooled mean difference (μm) of average pRNFL was − 4.85 (95% CI [− 6.12, − 3.58]); the pooled mean difference (μm) of four quadrants were − 2.30 (95% CI [

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Central retina changes in Parkinson’s disease: a systematic review and meta-analysis

Huang

Zhang

et al. 2020

J Neurol

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Evaluation of retinal alterations in Parkinson disease and tremor diseases

Cited by 14 publications

References 26 publications

Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: A systematic review and meta‐analysis

Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: A systematic review and meta‐analysis

The specific pattern of retinal nerve fiber layer thinning in Parkinson’s disease: a systematic review and meta-analysis

Central retina changes in Parkinson’s disease: a systematic review and meta-analysis

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