Evaluation of Reticuloendothelial Function in Man

Humoral mediated macrophage response during tumour growth

“…This technique has been used previously in the experimental evaluation of phagocytic activity in animals and humans and the selective localization ofthis test colloid in macrophages, especially in hepatic Kupffer cells has been confirmed by electron micro-scopy (Saba, 1970b;Salky et al, 1964). The test emulsion was prepared as an anhydrous base by high-speed blendorization of 1311_ labelled triolein (Mallinckrodt Nuclear, St Louis, Mo.…”

Age-Dependent Red Cell Phagocytosis and Activity of the Rabbit Reticulohistiocytic System

“…Salkin et al [19] found that about 80-90% of the RHS were localized in the liver, about 5-10% in the spleen and the remaining RHS cells can be found in the vascular endothelium. Our re sults are in agreement with these figures.…”

“…Recent investigations have shown a dis 1 This work was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG), SFP: Biol ogy of Aging. tribution of RHS cells in which the spleen appears to play only a smaller part as an RHS cell carrier [19,20] whereas the liver plays the main role. The following investigations were carried out to determine the distribu tion of RHS cells.…”

Decreased resistance to intravenous tumour-cell challenge during reticuloendothelial depression following surgery1

“…Reticuloendothelial (RE) phagoeytic function was assessed w%ith a colloid clearance technique coupled with in vivo colloid distribution studies (Saba and Antikatzides, 1975;Saba and Di Luzio, 1969;Salky et al, 1964). The [1311] gelatinized "' RE test lipid emulsion ", previously shown to be selectively removed by the process of phagocytosis, especially by the liver and spleen, was utilized (Saba and Di Luzio, 1969;Salky et al, 1964).…”

“…The [1311] gelatinized "' RE test lipid emulsion ", previously shown to be selectively removed by the process of phagocytosis, especially by the liver and spleen, was utilized (Saba and Di Luzio, 1969;Salky et al, 1964). The emulsion was prepared from glycerol, [1311] [1311] radioactivity was plotted semilogarithmically against time in minutes, and clearance half-times (t/2) as well as the global phagocytic index (K) for the vascular phagocytic removal of the colloid were determined.…”