Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC–STBSG) recommendations for pathological examination and reporting

Wardelmann, Eva; Haas, Rick L.; Bovée, Judith V.M.G.; Terrier, P.; Lazar, Alexander J.; Messiou, Christina; Lepéchoux, C.; Hartmann, Wolfgang; Collin, Françoise; Fisher, Cyril; Mechtersheimer, Gunhild; Tos, Angelo Paolo Dei; Stacchiotti, Silvia; Jones, Robin L.; Gronchi, Alessandro; Bonvalot, S.

doi:10.1016/j.ejca.2015.09.021

Cited by 112 publications

(80 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Advances in multidisciplinary management over the past decades have significantly increased the OS of adult sarcoma . In the present study, the 43 patients managed with a combination of surgical resection plus radiotherapy plus chemotherapy had a mean survival of 55 months versus 76 months for the 67 patients treated with surgery plus chemotherapy, 39 months for the eight patients treated with surgery plus radiotherapy, 69 months for the 29 patients treated with surgery alone and 13 months for the 25 patients treated without surgery.…”

Section: Discussionmentioning

confidence: 55%

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Wang

Tan

et al. 2017

Int J of Urology

View full text Add to dashboard Cite

Abbreviations & Acronyms B = bladder HR = hazard ratio K = kidney LRFS = local recurrence-free survival MFS = metastasis-free survival NR = not reported OS = overall survival P = paratesticular RMS = rhabdomyosarcoma Objectives: To report our institutional experience in the management of adult genitourinary sarcoma. Methods: This was a retrospective analysis of data on adult genitourinary sarcoma treated at the West China Hospital, Sichuan University, Chengdu, Sichuan, China from 1985 to 2010. Clinicopathological parameters were analyzed to determine their impact on overall, recurrence-free and metastasis-free survivals. Results: A total of 46 women and 142 men were included, with a median age of 42 years. Of these, 152 cases were high-grade. The most common site was the paratesticular region. Surgical resection was carried out in 155 patients (82.4%), with negative margin in 106. After a minimum follow up of 5 years, 20 patients (11.6%) survived disease-free, 14 (8.1%) were alive with disease and 138 (80.2%) died of disease. Survival rates at 1, 3 and 5 years were 91.3%, 64.0% and 47.7%. In univariate analyses, liposarcoma, high grade, metastasis at diagnosis, a lack of surgical resection and positive margin were predictive of unfavorable survival. In multivariate analyses, high grade, a lack of surgical resection and chemotherapy were independent predictors of poor survival. Conclusions: Adult genitourinary sarcoma is an aggressive malignancy, usually presenting at advanced stage, with a high incidence of recurrence and metastasis. Complete resection and selective combination of chemotherapy and radiotherapy might constitute the optimal treatment for this disease.

show abstract

Section: Discussionmentioning

confidence: 55%

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Wang

Tan

et al. 2017

Int J of Urology

View full text Add to dashboard Cite

show abstract

“…The features favouring morphological responders included fibrosis, necrosis, cholesterol clefts, haemosiderin‐laden macrophages, foamy histiocytes, inflammation, cytoplasmic degeneration, pleomorphism, bizarre nuclei, and tumour architecture . Similarly, in soft tissue and bone sarcomas, the NAC effect was assessed by evaluating the percentage of the area of tumour response relative to that of the residual tumour; patients who showed good response showed better survival . Although necrosis was long regarded as the only morphological evidence of tumour response, foamy or haemosiderin‐laden macrophages, fibrosis and smudgy chromatin were recently added as features indicative of response that should be incorporated in the evaluation of the NAC effect in soft tissue and bone sarcomas .…”

Section: Discussionmentioning

confidence: 99%

Prognostic pathological factors in radical cystectomy after neoadjuvant chemotherapy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Criteria for inclusion were: measurable tumor with MRI, available MRI performed <28 days before the first cycle of NAC (baseline, MRI_0) and between cycles 2 and 3 of NAC (early evaluation, MRI_1), 4 to 6 cycles of NAC, and histological response assessment on surgical specimen by an expert pathologist following published guidelines . A threshold of <10% of viable cells assessed on whole tumor defined good histological response (good‐HR) …”

Section: Methodsmentioning

confidence: 99%

T₂‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy.

Crombé

Périer

Kind

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Standard of care for patients with high‐grade soft‐tissue sarcoma (STS) are being redefined since neoadjuvant chemotherapy (NAC) has demonstrated a positive effect on patients' outcome. Yet response evaluation in clinical trials still relies on RECIST criteria. Purpose To investigate the added value of a Delta‐radiomics approach for early response prediction in patients with STS undergoing NAC. Study Type Retrospective. Population Sixty‐five adult patients with newly‐diagnosed, locally‐advanced, histologically proven high‐grade STS of trunk and extremities. All were treated by anthracycline‐based NAC followed by surgery and had available MRI at baseline and after two chemotherapy cycles. Field Strength/Sequence Pre‐ and postcontrast enhanced T1‐weighted imaging (T1‐WI), turbo spin echo T2‐WI at 1.5 T. Assessment A threshold of <10% viable cells on surgical specimens defined good response (Good‐HR). Two senior radiologists performed a semantic analysis of the MRI. After 3D manual segmentation of tumors at baseline and early evaluation, and standardization of voxel‐sizes and intensities, absolute changes in 33 texture and shape features were calculated. Statistical Tests Classification models based on logistic regression, support vector machine, k‐nearest neighbors, and random forests were elaborated using crossvalidation (training and validation) on 50 patients ("training cohort") and was validated on 15 other patients ("test cohort"). Results Sixteen patients were good‐HR. Neither RECIST status (P = 0.112) nor semantic radiological variables were associated with response (range of P‐values: 0.134–0.490) except an edema decrease (P = 0.003), although 14 shape and texture features were (range of P‐values: 0.002–0.037). On the training cohort, the highest diagnostic performances were obtained with random forests built on three features: Δ_Histogram_Entropy, Δ_Elongation, Δ_Surrounding_Edema, which provided: area under the curve the receiver operating characteristic = 0.86, accuracy = 88.1%, sensitivity = 94.1%, and specificity = 66.3%. On the test cohort, this model provided an accuracy of 74.6% but 3/5 good‐HR were systematically ill‐classified. Data Conclusion A T2‐based Delta‐radiomics approach might improve early response assessment in STS patients with a limited number of features. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:497–510.

show abstract

Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC–STBSG) recommendations for pathological examination and reporting

Cited by 112 publications

References 36 publications

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Prognostic pathological factors in radical cystectomy after neoadjuvant chemotherapy

T₂‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy.

Contact Info

Product

Resources

About

Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC–STBSG) recommendations for pathological examination and reporting

Cited by 112 publications

References 36 publications

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Prognostic pathological factors in radical cystectomy after neoadjuvant chemotherapy

T2‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy.

Contact Info

Product

Resources

About

T₂‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy.