Evaluation of respiratory impairment in patients with systemic lupus erythematosus with the six-minute walk test

Abstract

Six-minute walk testOxygen saturation Respiratory function test Questionnaires a b s t r a c t Objective: Evaluate SLE stable patients, without overt respiratory compromise, by means of 6MWT. Casuistic and methods: Forty-five stable SLE patients were enrolled. The ATS/ERS protocol for 6MWT, was used and two parameters with cut-off points were chosen. Results: Forty-two patients were women. The mean age was 39 ± 11.4 years; mean duration of disease, 121 ± 93.1 months; mean value of MRC, 2 ± 0; mean FVC, 85.9 ± 34.2%; mean FEV1, 67.5 ± 21.6%; mean MIP, 82 ± 58.4%; mean MEP, 78 ± 37.3%; mean heart rate at rest, 75 ± 12.8 bpm; mean respiratory rate at rest, 19 ± 5.3 bpm; mean 6MWD, 478 ± 82 m; mean SpO2 at rest was 98 ± 0.8%; mean fall in SpO2, 4 ± 6 points. When the study population was divided according to the 400-m walk distance cut-off value, the heart rate immediately before the test was significant lower in those participants who walked less than 400 m (p = 0.0043), just like the value of Borg scale (p = 0.0036); according to the presence of saturation ≥ 4, heart rate at the end of the test was significantly higher in those participants who were showing desaturation (p = 0.0170); MEP (p = 0.0282) and 6MWD (p = 0.0291) were significantly lower, and MIP showed a tendency towards being smaller (p = 0.0504). FVC < normal inferior limit was significantly associated with the group with desaturation (p = 0.0274). Conclusion: Compared to 6MWD, desaturation was better suited to find the patients with the most compromised indexes in respiratory function tests. Avaliação do comprometimento respiratório em pacientes com lúpus eritematoso sistêmico com o teste de caminhada de seis minutosPalavras-chave: Lúpus eritematoso sistêmico (LES) Teste de caminhada de seis minutos Saturação de oxigênio Teste de função respiratória Questionários r e s u m o Objetivo: Avaliar pacientes com LES estável, sem comprometimento respiratório evidente, por meio do TC6M. Casuística e métodos: Foram recrutados 45 pacientes com LES estável. Foi utilizado o protocolo ATS/ERS para TC6M, tendo sido escolhidos dois parâmetros com pontos de corte. Resultados: Quarenta e dois dos pacientes eram mulheres. A média de idade foi 39 ± 11,4 anos;a duração média da doença, 121 ± 93,1 meses; valor médio de MRC 2 ± 0; CVF média 85,9 ± 34,2%; VEF1 médio 67,5 ± 21,6%; PIM média 82 ± 58,4%; PEM média 78 ± 37,3%; frequência cardíaca média em repouso 75 ± 12,8 bpm; frequência respiratória média em repouso 19 ± 5,3 bpm; Distância média no TC6M 478 ± 82 m; SpO2 média em repouso 98 ± 0,8%; queda média em SpO2 4 ± 6 pontos. Quando a população em estudo foi dividida de acordo com o valor de corte de 400 m de distância caminhada, a frequência cardíaca imediatamente antes do teste foi significativamente menor naqueles participantes que caminharam menos de 400 m (p = 0,0043), da mesma forma que o valor da escala de Borg (p = 0,0036). De acordo com a presença de saturação ≥ 4, a frequência cardíaca ao final do teste estava significativamente mais elevada naqueles participant...

Echocardiography and 6-Minute Walk Test for Assessing Disease Progression in Systemic Lupus Erythematosus

“…Because SLE is a rare disease, performing research in a large number of patients from one center is often not possible. saturation and the distance traveled by the patients in 6MWT [24]. In both studies, a significantly smaller distance in 6MWT was covered by patients with SLE.…”

Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

“…Balsamo et al revealed a significant decrease in distance walked in 6MWT in Brazilian premenopausal female SLE patients and found a positive correlation between exercise capacity and quality of life [25]. Additionally, Leite et al presented that the SpO 2 physiological parameter was superior used to finding respiratory impairment in patients during the 6-MWT [26]. However, they did not assess how other physiological parameters changed in SLE patients at 6-MWT.…”

“…Background This study investigated physical activity, peripheral muscle strength, exercise capacity, sleep, fatigue, anxiety and depression in patients with systemic lupus erythematosus (SLE). Material and Methods Twenty-six patients with SLE, median age 32.5 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) years, and 29 healthy individuals, median age 30 (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) years, were included. Exercise capacity (6-minute walk test (6MWT)), peripheral muscle strength (dynamometer), physical activity (Mi Band 4 smart band), fatigue (Fatigue Severity Scale (FSS)), anxiety and depression (Hospital Anxiety Depression scale (HAD)), quality of life (SLE-specific QOL scale (SLEQoL)) and sleep (Pittsburgh Sleep Quality Index (PSQI)) were assessed.…”