Evaluation of resorbable barriers for preventing surgical adhesions

Arnold, Peter; Green, Colleen W.; Foresman, Pamela A.; Rodeheaver, George T.

doi:10.1016/s0015-0282(99)00464-1

Cited by 65 publications

(44 citation statements)

References 19 publications

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“…Detachment of these adhesions required peak forces greater than, but of a similar order of magnitude, to those reported previously 30,31 (2.43 Ϯ 0.27 N). The energy required for adhesiolysis in controls was 59 Ϯ 9.6 mJ.…”

Section: Adhesion Developmentsupporting

confidence: 81%

“…30,31 An analysis of variance found significant differences between the groups for both parameters (p Ͻ 0.001).…”

Section: Peak Force and Energy Required To Breakmentioning

confidence: 97%

“…The model is essentially as reported previously 30,31 in which abdominal adhesions are induced by creating specific abdominal wounds. These wounds are allowed to make contact naturally without the use of sutures or other foreign bodies.…”

Section: Animal Modelmentioning

confidence: 99%

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The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Wiseman

Lyachovetsky²,

Keidan

et al. 2003

J Biomed Mater Res

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The objective of the research was to determine the effect of the type, dose, and volume of anti-fibrinolytic agents (tranexamic acid, aprotinin) added to fibrin formulations, on adhesion development. Adhesions were induced in 228 male rats by creating apposing parietal and visceral peritoneal defects. Animals were randomized to receive no treatment or a fibrin formulation containing aprotinin or tranexamic acid. Seven days later the incidence of adhesions, and the force and energy required to detach them, were determined. Adhesions developed in 13/13 rats in the control and aprotinin groups. Treatment with fibrin (100 mg/ml tranexamic acid) resulted in adhesions in 4/14 rats (as strips, p < or = 0.0005), 4/10 rats (as spray, p < or = 0.0036), and 12/15 rats (by drip). The reduction of adhesions was dependent on the concentration of tranexamic acid with strip and spray application. Using commercial formulations, tranexamic-acid-containing fibrin (10/15, p = 0.042), but not aprotinin-containing fibrin (13/15), reduced the incidence of side-wall adhesions from 15/15 in controls. Fibrin containing either tranexamic or aprotinin reduced the incidence and severity of adhesions. This effect was greater when tranexamic acid was used and was dependent on the mode of administration, the volume, and to a degree, the concentration of tranexamic acid.

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Section: Adhesion Developmentsupporting

confidence: 81%

“…30,31 An analysis of variance found significant differences between the groups for both parameters (p Ͻ 0.001).…”

Section: Peak Force and Energy Required To Breakmentioning

confidence: 97%

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The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Wiseman

Lyachovetsky²,

Keidan

et al. 2003

J Biomed Mater Res

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“…However, biodegradable barriers appear to be the most promising tools available for keeping adjacent organs separate following surgery 3 . The efficacy of these barriers has been demonstrated in clinical trials 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Pucciarelli

Codello

Rosato

et al. 2002

British Journal of Surgery

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“…Hyaluronic acid (HA), is unique among glycosaminoglycans in that it is nonsulfated, forms E-mail address: tammy_luttrell@msn.com in the plasma membrane, instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions. in a stabilized form; it provides a 3D-biopolymer scaffold, that promotes endothelial cell migration 11 ; thus supporting neo-vascularization, a foundation of granulation tissue and extracellular matrix revitalization. Chitosan (CS) is a marine polysaccharide that in and of itself has hemostatic, anti-microbial and antiinflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Challenges of Complex Open Abdominal Wound Management in Trauma: A Novel Use of Chitosan and Hyaluronic Acid as a 3-Dimensional Scaffold to Overcome Resilient Open Abdomen Infections

Luttrell¹,

Khashwj²,

Ingalls³

et al. 2015

Journal of the American College of Clinical Wound Specialists

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Evaluation of resorbable barriers for preventing surgical adhesions

Cited by 65 publications

References 19 publications

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Challenges of Complex Open Abdominal Wound Management in Trauma: A Novel Use of Chitosan and Hyaluronic Acid as a 3-Dimensional Scaffold to Overcome Resilient Open Abdomen Infections

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